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ACTIVE NOT RECRUITING Phase 2

A Study to Evaluate the Efficacy, Safety, and Tolerability of IMVT-1402 in Adult Participants With Active, Difficult to Treat Rheumatoid Arthritis

NCT06754462 · View on ClinicalTrials.gov ↗

Study Summary

This Phase 2b, multicenter, double-blind, placebo-controlled, randomized withdrawal study is designed to assess the efficacy and safety of IMVT-1402 in adult participants with active, difficult-to-treat, anti-citrullinated protein autoantibody (ACPA) positive rheumatoid arthritis (RA).

Conditions Studied

Interventions

  • DRUG Placebo
  • DRUG IMVT-1402

Study Locations (20)

California

  • Site Number - 1022 — Covina
  • Site Number - 1028 — San Leandro
  • Site Number - 1024 — Temecula
  • Site Number - 1033 — Tujunga
  • Site Number - 1023 — Whittier

Florida

  • Site Number - 1015 — Jupiter
  • Site Number - 1002 — Miami
  • Site Number - 1027 — Plantation
  • Site Number - 1005 — Winter Park
  • Site Number - 1012 — Zephyrhills

Maryland

  • Site Number - 1006 — Cumberland
  • Site Number - 1007 — Hagerstown
  • Site Number - 1031 — Rockville

Arizona

  • Site Number - 1018 — Mesa
  • Site Number - 1019 — Sun City

Colorado

  • Site Number - 1020 — Denver

Georgia

  • Site Number - 1001 — Gainesville

Illinois

  • Site Number - 1034 — Chicago

Massachusetts

  • Site Number - 1008 — Worcester

Trial Details

FieldValue
Enrollment Target 120 participants
Start Date 2025-01-10
Est. Completion 2027-09
Phase Phase 2

Sponsor

Immunovant Sciences

12 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06754462

The ClinicalTrials.gov registry entry for NCT06754462 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 120 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Immunovant Sciences, which has 12 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Rheumatoid Arthritis appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06754462 reports 20 study locations spanning 9 distinct geographic areas — top geographies include California, Florida, Maryland. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06754462 about?

NCT06754462 is a clinical study titled "A Study to Evaluate the Efficacy, Safety, and Tolerability of IMVT-1402 in Adult Participants With Active, Difficult to Treat Rheumatoid Arthritis". This Phase 2b, multicenter, double-blind, placebo-controlled, randomized withdrawal study is designed to assess the efficacy and safety of IMVT-1402 in adult participants with active, difficult-to-treat, anti-citrullinated protein autoantibody (ACPA) positive rheumatoid arthritis (RA).

What is the current status of trial NCT06754462?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 120 participants. The study started on 2025-01-10. Estimated completion is 2027-09.

What conditions does trial NCT06754462 study?

This clinical trial studies the following conditions: Rheumatoid Arthritis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06754462?

The interventions under investigation include: Placebo (DRUG), IMVT-1402 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06754462?

This trial is sponsored by Immunovant Sciences, which has 12 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06754462 being conducted?

This trial has 20 study locations across Arizona, California, Colorado, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial