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ClinicalTrials.gov 37 recruiting now official registry

Rheumatoid Arthritis clinical trials

37 of 199 indexed Rheumatoid Arthritis trials are currently recruiting.

199 US clinical trials · 37 currently recruiting

Rheumatoid Arthritis is the subject of 199 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 32 are in Phase 3-4 (later-stage) and 77 in Phase 1-2 (earlier-stage). The most active sponsor is Zimmer Biomet, running 13 of these trials.

The research picture

Rheumatoid Arthritis has 199 registered US clinical trials, 37 of them open to new participants right now, about 19% of the total.

37
recruiting participants now
19%
of trials open to enrollment
32
in Phase 3–4 (later-stage)
13
top sponsor: Zimmer Biomet
Phase 133Phase 244Phase 325Phase 47

Active & Recent Trials

199 total, page 1 of 4

RECRUITING 20,000 participants

Exactech Shoulder Post Market Clinical Follow-up Study

Exactech

NCT05603728

RECRUITING 1,410 participants

Prospective, Multi-Center, Observational, Whole Blood Specimen Collection Study in Participants with Rheumatoid Arthritis with Inadequate Response or Intolerance to a DMARD Starting a New BDMARD or TsDMARD Treatment +/- CsDMARD

Aqtual

NCT05936970

RECRUITING 1,100 participants

PREDICT Therapy Selection for JAK, T-cell, or IL-6 Inhibitor Therapies Using a Molecular Signature Response Classifier (PREDICT)

Scipher Medicine

NCT06390709

RECRUITING 1,000 participants

Maternal Autoimmune Disease Research Alliance (MADRA) Registry

Duke University

NCT03276923

RECRUITING Phase 3 924 participants

Ra-pro Pragmatic Trial

University of Alabama at Birmingham

NCT04692493

RECRUITING NA 800 participants

Physica System Total Knee Replacement Registry Study

Limacorporate S.p.a

NCT03048201

RECRUITING 760 participants

Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)

Zimmer Biomet

NCT05787821

RECRUITING 750 participants

Rheumatoid Arthritis Patients at Risk for Interstitial Lung Disease

University of Colorado, Denver

NCT03297775

RECRUITING 500 participants

Rheumatology Diet Study

University of Central Florida

NCT06339957

RECRUITING 450 participants

Defining the Molecular and Radiologic Phenotype of Progressive RA Interstitial Lung Disease

University of Colorado, Denver

NCT06397677

RECRUITING Phase 3 400 participants

Treatment of Rheumatoid Arthritis With DMARDs: Predictors of Response

University of Nebraska

NCT03414502

RECRUITING Phase 2 380 participants

An Adaptive Phase 2a/2b Study of LY3871801 in Adult Participants With Rheumatoid Arthritis

Eli Lilly and Company

NCT05848258

RECRUITING Phase 2 320 participants

A Study to Investigate Efficacy and Safety of AZD1163 in Participants With Rheumatoid Arthritis

AstraZeneca

NCT07276581

RECRUITING Phase 1 300 participants

Nivolumab in Treating Patients With Autoimmune Disorders and Advanced, Metastatic, or Unresectable Cancer

National Cancer Institute (NCI)

NCT03816345

RECRUITING Phase 2 285 participants

A Study of SPY072 in Rheumatic Disease

Spyre Therapeutics

NCT07148414

RECRUITING Phase 1 270 participants

A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

NCT05869955

RECRUITING NA 200 participants

Creating Health Course Study for People With Rheumatological Conditions

Terry L. Wahls

NCT07180537

RECRUITING Phase 2 200 participants

Dynamic Treatment Regiments for Glucocorticoid Tapering

VA Office of Research and Development

NCT06072768

RECRUITING Phase 2 180 participants

A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis

AbbVie

NCT06972446

RECRUITING Phase 2 160 participants

A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)

Hoffmann-La Roche

NCT07137598

RECRUITING 150 participants

Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes

University of Florida

NCT05277025

RECRUITING NA 124 participants

Effect of Anti-inflammatory Diet in Rheumatoid Arthritis

University of California, San Diego

NCT04748809

RECRUITING NA 118 participants

EMPHASYS Cup Positioning in THA With Non-Invasive Navigation (Velys Hip Navigation (VHN))

DePuy Orthopaedics

NCT06631638

RECRUITING 100 participants

Early Rheumatoid Arthritis Lung Disease Study

University of Nebraska

NCT03192267

RECRUITING Phase 1 75 participants

Study of GS-0151 in Participants With Rheumatoid Arthritis

Gilead Sciences

NCT06902519

RECRUITING Phase 1 75 participants

MAD Study of IA-14069

ILAb Co.

NCT05533372

RECRUITING 72 participants

Analysis of T and B Cell Repertoire Changes in Response to Orencia® (Abatacept) in Rheumatoid Arthritis

Hospital for Special Surgery, New York

NCT05782335

RECRUITING Phase 1 72 participants

A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.

AstraZeneca

NCT06916806

RECRUITING Phase 1 48 participants

Study Evaluating Safety, Tolerability, PK/PD of Surovatamig in Adult RA or SLE Participants

AstraZeneca

NCT07201558

RECRUITING Phase 1 40 participants

Imaging of Lymphatic Vessels in People with Rheumatoid Arthritis (RA)

University of Rochester

NCT05197530

RECRUITING Phase 4 30 participants

NSAIDs vs. Coxibs in the Presence of Aspirin

Inova Health Care Services

NCT03699293

RECRUITING Phase 1 30 participants

Open-label Single-Center Study to Evaluate the Safety and Efficacy of Combining Rituximab and AB-101 in B-cell Associated Autoimmune Diseases.

IRIS Research and Development

NCT06581562

RECRUITING NA 28 participants

ConsideRAte Study - Splenic Stimulation for RA

Galvani Bioelectronics

NCT05003310

RECRUITING Phase 1 27 participants

A Study of AZD0120 in Autoimmune Diseases

AstraZeneca

NCT07295847

RECRUITING NA 25 participants

Improving Hypertension Control in Rheumatoid Arthritis

Duke University

NCT05760898

RECRUITING Phase 1 24 participants

Study of Single Doses of SBT777101 in Subjects With Rheumatoid Arthritis

Sonoma Biotherapeutics

NCT06201416

RECRUITING NA 15 participants

Targeted Remotely-delivered Anti-inflammatory Interventions With Exercise for Rheumatoid Arthritis

Duke University

NCT06841562

ACTIVE NOT RECRUITING 521,292 participants

Frequency and Complications of Major Orthopedic Procedures in Medicare Beneficiaries

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

NCT02281747

ACTIVE NOT RECRUITING Phase 3 1,629 participants

A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Adults With Rheumatoid Arthritis Who Are on a Stable Dose of Methotrexate and Who Have an Inadequate Response to Methotrexate

AbbVie

NCT02629159

ACTIVE NOT RECRUITING 1,598 participants

Brigham and Women's Rheumatoid Arthritis Sequential Study

Brigham and Women's Hospital

NCT01793103

ACTIVE NOT RECRUITING 925 participants

OTIS Cimzia Pregnancy Registry

University of California, San Diego

NCT01797224

ACTIVE NOT RECRUITING NA 737 participants

Persona Total Knee Arthroplasty Outcomes Study

Zimmer Biomet

NCT02255383

ACTIVE NOT RECRUITING Phase 3 487 participants

Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib Compared to Subcutaneous Adalimumab in Adult Participants With Moderate to Severe Rheumatoid Arthritis

AbbVie

NCT05814627

ACTIVE NOT RECRUITING Phase 2 420 participants

A Study of Efficacy and Safety of Rosnilimab in Subjects with Moderate to Severe Rheumatoid Arthritis (RENOIR)

AnaptysBio

NCT06041269

ACTIVE NOT RECRUITING Phase 3 338 participants

A Study to Compare the Response to Treatment With Abatacept vs Adalimumab, on Background Methotrexate, in Adults With Early, Seropositive, and Shared Epitope-positive Rheumatoid Arthritis and an Inadequate Response to Methotrexate

Bristol-Myers Squibb

NCT04909801

ACTIVE NOT RECRUITING NA 313 participants

Insignia™ Hip Stem Outcomes Study

Stryker Orthopaedics

NCT05144191

ACTIVE NOT RECRUITING NA 300 participants

Cemented vs Cementless Persona Keel RCT

Zimmer Biomet

NCT05630053

ACTIVE NOT RECRUITING 299 participants

A Global Clinical Study Investigating the Safety and Effectiveness of Smith and Nephew's Porous Knee System in Patients Who Need a Total Knee Replacement Due to Degenerative Arthritis, Post-traumatic Arthritis or Inflammatory Arthritis

Smith & Nephew

NCT05197036

ACTIVE NOT RECRUITING 255 participants

A Prospective, Clinical Investigation of the Vanguard 360 Revision Knee

Zimmer Biomet

NCT01542580

ACTIVE NOT RECRUITING Phase 3 243 participants

Vagus Nerve Stimulation for Moderate to Severe Rheumatoid Arthritis

SetPoint Medical Corporation

NCT04539964

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Phase Distribution

PhaseTrial count
Phase 1 33
Phase 2 44
Phase 3 25
Phase 4 7

Top Sponsors

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Rheumatoid Arthritis Trial Landscape

199 indexed Rheumatoid Arthritis studies · 37 recruiting (19%).

Phase mix: 32 late (III/IV) vs 77 early (I/II).

Top sponsor: Zimmer Biomet (13 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Rheumatoid Arthritis?

PlainTrial tracks 199 US clinical trials for Rheumatoid Arthritis, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Rheumatoid Arthritis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.