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Rheumatoid Arthritis: early-phase trial registry
37 of 199 indexed Rheumatoid Arthritis trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #50 of 28,707 conditions by registered trial count.
199 US clinical trials · 37 currently recruiting · #50 of 28,707 conditions by registered trial count
Rheumatoid Arthritis: 199 US clinical trials tracked, 37 recruiting.
Rheumatoid Arthritis is the subject of 199 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 32 are in Phase 3-4 (later-stage) and 77 in Phase 1-2 (earlier-stage). The most active sponsor is Zimmer Biomet, running 13 of these trials.
Enrollment posture brief
Registry condition rheumatoid-arthritis
OPEN 37 | RECR 19% | LATE 32 | EARLY 77 | RANK #50 | SPON 13
Volume-matched condition peers
Nearest open-share peer: Leukemia (19% recruiting · 274 trials)
Rheumatoid Arthritis lists 37 open slots (19% of 199 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Rheumatoid Arthritis on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Rheumatoid Arthritis is recruiting below its size-band peers.
37 of 199 indexed trials (18.6%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Rheumatoid Arthritis trials is spread across many organizations.
Zimmer Biomet accounts for 13 of 199 trials (6.5%). 114 distinct sponsors appear on at least one study for this condition label.
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Typical Rheumatoid Arthritis enrolment sits around 154 participants.
Median target enrolment is 154 among the 198 trials that report a genuine target (sentinel values excluded). 78 of those (39.4%) plan for fewer than 100 participants.
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Rheumatoid Arthritis research is mostly interventional.
154 interventional and 45 observational studies make up this index (77.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
199 total, page 1 of 4
Exactech Shoulder Post Market Clinical Follow-up Study
Exactech
NCT05603728
Prospective, Multi-Center, Observational, Whole Blood Specimen Collection Study in Participants with Rheumatoid Arthritis with Inadequate Response or Intolerance to a DMARD Starting a New BDMARD or TsDMARD Treatment +/- CsDMARD
Aqtual
NCT05936970
PREDICT Therapy Selection for JAK, T-cell, or IL-6 Inhibitor Therapies Using a Molecular Signature Response Classifier (PREDICT)
Scipher Medicine
NCT06390709
Maternal Autoimmune Disease Research Alliance (MADRA) Registry
Duke University
NCT03276923
Ra-pro Pragmatic Trial
University of Alabama at Birmingham
NCT04692493
Physica System Total Knee Replacement Registry Study
Limacorporate S.p.a
NCT03048201
Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)
Zimmer Biomet
NCT05787821
Rheumatoid Arthritis Patients at Risk for Interstitial Lung Disease
University of Colorado, Denver
NCT03297775
Rheumatology Diet Study
University of Central Florida
NCT06339957
Defining the Molecular and Radiologic Phenotype of Progressive RA Interstitial Lung Disease
University of Colorado, Denver
NCT06397677
Treatment of Rheumatoid Arthritis With DMARDs: Predictors of Response
University of Nebraska
NCT03414502
An Adaptive Phase 2a/2b Study of LY3871801 in Adult Participants With Rheumatoid Arthritis
Eli Lilly and Company
NCT05848258
A Study to Investigate Efficacy and Safety of AZD1163 in Participants With Rheumatoid Arthritis
AstraZeneca
NCT07276581
Nivolumab in Treating Patients With Autoimmune Disorders and Advanced, Metastatic, or Unresectable Cancer
National Cancer Institute (NCI)
NCT03816345
A Study of SPY072 in Rheumatic Disease
Spyre Therapeutics
NCT07148414
A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)
Juno Therapeutics, Inc., a Bristol-Myers Squibb Company
NCT05869955
Creating Health Course Study for People With Rheumatological Conditions
Terry L. Wahls
NCT07180537
Dynamic Treatment Regiments for Glucocorticoid Tapering
VA Office of Research and Development
NCT06072768
A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis
AbbVie
NCT06972446
A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)
Hoffmann-La Roche
NCT07137598
Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes
University of Florida
NCT05277025
Effect of Anti-inflammatory Diet in Rheumatoid Arthritis
University of California, San Diego
NCT04748809
EMPHASYS Cup Positioning in THA With Non-Invasive Navigation (Velys Hip Navigation (VHN))
DePuy Orthopaedics
NCT06631638
Early Rheumatoid Arthritis Lung Disease Study
University of Nebraska
NCT03192267
Study of GS-0151 in Participants With Rheumatoid Arthritis
Gilead Sciences
NCT06902519
MAD Study of IA-14069
ILAb Co.
NCT05533372
Analysis of T and B Cell Repertoire Changes in Response to Orencia® (Abatacept) in Rheumatoid Arthritis
Hospital for Special Surgery, New York
NCT05782335
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.
AstraZeneca
NCT06916806
Study Evaluating Safety, Tolerability, PK/PD of Surovatamig in Adult RA or SLE Participants
AstraZeneca
NCT07201558
Imaging of Lymphatic Vessels in People with Rheumatoid Arthritis (RA)
University of Rochester
NCT05197530
NSAIDs vs. Coxibs in the Presence of Aspirin
Inova Health Care Services
NCT03699293
Open-label Single-Center Study to Evaluate the Safety and Efficacy of Combining Rituximab and AB-101 in B-cell Associated Autoimmune Diseases.
IRIS Research and Development
NCT06581562
ConsideRAte Study - Splenic Stimulation for RA
Galvani Bioelectronics
NCT05003310
A Study of AZD0120 in Autoimmune Diseases
AstraZeneca
NCT07295847
Improving Hypertension Control in Rheumatoid Arthritis
Duke University
NCT05760898
Study of Single Doses of SBT777101 in Subjects With Rheumatoid Arthritis
Sonoma Biotherapeutics
NCT06201416
Targeted Remotely-delivered Anti-inflammatory Interventions With Exercise for Rheumatoid Arthritis
Duke University
NCT06841562
Frequency and Complications of Major Orthopedic Procedures in Medicare Beneficiaries
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NCT02281747
A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Adults With Rheumatoid Arthritis Who Are on a Stable Dose of Methotrexate and Who Have an Inadequate Response to Methotrexate
AbbVie
NCT02629159
Brigham and Women's Rheumatoid Arthritis Sequential Study
Brigham and Women's Hospital
NCT01793103
OTIS Cimzia Pregnancy Registry
University of California, San Diego
NCT01797224
Persona Total Knee Arthroplasty Outcomes Study
Zimmer Biomet
NCT02255383
Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib Compared to Subcutaneous Adalimumab in Adult Participants With Moderate to Severe Rheumatoid Arthritis
AbbVie
NCT05814627
A Study of Efficacy and Safety of Rosnilimab in Subjects with Moderate to Severe Rheumatoid Arthritis (RENOIR)
AnaptysBio
NCT06041269
A Study to Compare the Response to Treatment With Abatacept vs Adalimumab, on Background Methotrexate, in Adults With Early, Seropositive, and Shared Epitope-positive Rheumatoid Arthritis and an Inadequate Response to Methotrexate
Bristol-Myers Squibb
NCT04909801
Insignia™ Hip Stem Outcomes Study
Stryker Orthopaedics
NCT05144191
Cemented vs Cementless Persona Keel RCT
Zimmer Biomet
NCT05630053
A Global Clinical Study Investigating the Safety and Effectiveness of Smith and Nephew's Porous Knee System in Patients Who Need a Total Knee Replacement Due to Degenerative Arthritis, Post-traumatic Arthritis or Inflammatory Arthritis
Smith & Nephew
NCT05197036
A Prospective, Clinical Investigation of the Vanguard 360 Revision Knee
Zimmer Biomet
NCT01542580
Vagus Nerve Stimulation for Moderate to Severe Rheumatoid Arthritis
SetPoint Medical Corporation
NCT04539964
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 33 |
| Phase 2 | 44 |
| Phase 3 | 25 |
| Phase 4 | 7 |
Top Sponsors
Named interventions
Most-linked intervention names on Rheumatoid Arthritis records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Rheumatoid Arthritis trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Rheumatoid Arthritis page
199 registered trials, 37 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 37 Rheumatoid Arthritis trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Zimmer Biomet sponsors the most Rheumatoid Arthritis trials on record, review their full trial history before evaluating a specific study. See Zimmer Biomet's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Rheumatoid Arthritis condition card totals 199 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.