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RECRUITING Phase 2

A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)

NCT07137598 · View on ClinicalTrials.gov ↗

Study Summary

This study will assess the efficacy and safety of Afimkibart (also known as RO7790121) compared with placebo in participants with moderate to severe rheumatoid arthritis (RA) who have an inadequate response or intolerance to TNF and/or JAK inhibitors.

Conditions Studied

Interventions

  • DRUG Placebo
  • DRUG Afimkibart

Study Locations (20)

Other

  • UZ Leuven — Leuven
  • Bispebjerg og Frederiksberg Hospital — Frederiksberg
  • Nzoz Bif-Med — Bytom
  • Centrum Kliniczno-Badawcze J. Brzezicki, B. Górnikiewicz-Brzezicka Lekarze Spó?ka Partne — Elbl?g
  • Malopolskie Badania Kliniczne — Krakow
  • Zespol Poradni Specjalistycznych REUMED — Lublin
  • Twoja Przychodnia NCM — Nowa Sól

Texas

  • Accurate Clinical Management — Houston
  • DM Clinical Research — Tomball

Arizona

  • SunValley Arthritis Center Ltd. — Peoria

California

  • Inland Rheumatology Clinical Trials Incorporated — Upland

Florida

  • West Broward Rheumatology Associates, Inc. — Tamarac

Illinois

  • Willow Rheumatology and Wellness PLLC — Willowbrook

Louisiana

  • Accurate Clinical Research Inc. — Lake Charles

Pennsylvania

  • Altoona Center For Clinical Research — Duncansville

Trial Details

FieldValue
Enrollment Target 160 participants
Start Date 2025-12-05
Est. Completion 2027-10-02
Phase Phase 2

Sponsor

Hoffmann-La Roche

758 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07137598

The ClinicalTrials.gov registry entry for NCT07137598 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 160 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Hoffmann-La Roche, which has 758 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Rheumatoid Arthritis appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07137598 reports 20 study locations spanning 13 distinct geographic areas — top geographies include Other, Texas, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07137598 about?

NCT07137598 is a clinical study titled "A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)". This study will assess the efficacy and safety of Afimkibart (also known as RO7790121) compared with placebo in participants with moderate to severe rheumatoid arthritis (RA) who have an inadequate response or intolerance to TNF and/or JAK inhibitors.

What is the current status of trial NCT07137598?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 160 participants. The study started on 2025-12-05. Estimated completion is 2027-10-02.

What conditions does trial NCT07137598 study?

This clinical trial studies the following conditions: Rheumatoid Arthritis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07137598?

The interventions under investigation include: Placebo (DRUG), Afimkibart (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07137598?

This trial is sponsored by Hoffmann-La Roche, which has 758 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07137598 being conducted?

This trial has 20 study locations across Arizona, California, Florida, Illinois, Louisiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial