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NCT06972446 · ClinicalTrials.gov registry record · Phase 2
A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis
A Phase 2 study of Rheumatoid Arthritis, sponsored by AbbVie.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 180
- Enrollment target
- 20
- Study locations
NCT06972446 is a Phase 2 study of Rheumatoid Arthritis that is actively recruiting participants, run by AbbVie. The registered enrollment target is 180 participants, below the 4,690-participant average among 197 other Rheumatoid Arthritis trials with a reported enrollment target (96% lower). The trial reports 20 study locations across 7 states.
The verdict
NCT06972446, a Phase 2 study of Rheumatoid Arthritis, is actively recruiting participants, sponsored by AbbVie.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 180 participants
- Enrollment target
- 20
- Study locations
Study Summary
Rheumatoid Arthritis (RA) is a chronic inflammatory disease causing pain, stiffness, swelling and loss of joint function. This study will evaluate the efficacy and safety of targeted therapies through a series of substudies for the treatment of moderately to severely active Rheumatoid Arthritis (RA). This study currently includes 3 substudies evaluating different treatments in participants with RA. Substudy 1 will evaluate lutikizumab monotherapy (treatment given alone) compared to placebo (looks like the study treatment but contains no medicine). Substudy 2 will evaluate ravagalimab monotherapy compared to placebo and Substudy 3 will evaluate lutikizumab and ravagalimab combination therapy (treatments given together) compared to placebo. Approximately 180 participants who have failed 1 or 2 biologic/targeted synthetic disease-modifying antirheumatic drug (tsDMARD) therapies will be enrolled in the study at approximately 65 sites worldwide. There may be higher treatment burden for participants in this trial compared to their standard of care treatment without participating in this study. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Lutikizumab
- DRUG Ravagalimab
Study Locations (20)
Florida
- Highlands Advanced Rheumatology And Arthritis Center - Avon Park /ID# 272298 - Avon Park
- Clinical Research Of West Florida - Phase I Unit /ID# 272428 - Clearwater
- Neoclinical Research - Hialeah /ID# 272070 - Hialeah
- South Florida Rheumatology /ID# 278339 - Hollywood
- Swati Shah, MD Rheumatology /ID# 273624 - Jacksonville
- Life Clinical Trials /ID# 272589 - Margate
- HMD Research LLC /ID# 272432 - Orlando
- Clinical Research Of West Florida - Tampa - North Howard Avenue /ID# 272755 - Tampa
California
- Private Practice - Dr. David S. Hallegua /ID# 277608 - Beverly Hills
- Advanced Clinical Research Center, LLC dba TriWest Research Associates /ID# 277826 - Chula Vista
- Newport Huntington Medical Group /ID# 272439 - Huntington Beach
- Cohen Medical Centers /ID# 278341 - Thousand Oaks
- The Lundquist Institute /ID# 272481 - Torrance
- Inland Rheumatology & Osteoporosis Medical Group /ID# 272449 - Upland
Illinois
- Deerbrook Medical Associates /ID# 273439 - Libertyville
- Willow Rheumatology and Wellness, PLLC /ID# 272691 - Willowbrook
Arizona
- Sun Valley Arthritis Center /ID# 278331 - Peoria
Colorado
- Tekton Research - Fort Collins - East Harmony Road /ID# 272472 - Fort Collins
Louisiana
- Accurate Clinical Research (SMO/Network/Consortium) /ID# 272650 - Lake Charles
Michigan
- AA Medical Research Center - Grand Blanc /ID# 272496 - Grand Blanc
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 180 participants |
| Start Date | 2025-06-20 |
| Est. Completion | 2027-11 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06972446
The ClinicalTrials.gov registry entry for NCT06972446 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 180 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 4,690-participant average among 197 other Rheumatoid Arthritis trials with a reported enrollment target (96% lower). The listed sponsor is AbbVie, which has 526 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Rheumatoid Arthritis appearing as the primary indexed condition, and to 3 interventions - of which Placebo is the first listed.
NCT06972446 reports 20 study locations spanning 7 distinct geographic areas - top geographies include Florida, California, Illinois.
Frequently Asked Questions
What is clinical trial NCT06972446 about?
NCT06972446 is a clinical study titled "A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis". Rheumatoid Arthritis (RA) is a chronic inflammatory disease causing pain, stiffness, swelling and loss of joint function. This study will evaluate the efficacy and safety of targeted therapies through a series of substudies for the treatment of moderately to severely active Rheumatoid Arthritis (RA)...
What is the current status of trial NCT06972446?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 180 participants. The study started on 2025-06-20. Estimated completion is 2027-11.
What conditions does trial NCT06972446 study?
This clinical trial studies the following conditions: Rheumatoid Arthritis.
What interventions are being tested in trial NCT06972446?
The interventions under investigation include: Placebo (DRUG), Lutikizumab (DRUG), Ravagalimab (DRUG).
Who is sponsoring clinical trial NCT06972446?
This trial is sponsored by AbbVie, which has 526 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06972446 being conducted?
This trial has 20 study locations across Arizona, California, Colorado, Florida, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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