Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT07148414 · ClinicalTrials.gov registry record · Phase 2
A Study of SPY072 in Rheumatic Disease
A Phase 2 study of Rheumatoid Arthritis and Psoriatic Arthritis, sponsored by Spyre Therapeutics.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 285
- Enrollment target
- 20
- Study locations
NCT07148414 is a Phase 2 study of Rheumatoid Arthritis and Psoriatic Arthritis that is actively recruiting participants, run by Spyre Therapeutics. The registered enrollment target is 285 participants, below the 4,689-participant average among 197 other Rheumatoid Arthritis trials with a reported enrollment target (94% lower). The trial reports 20 study locations across 11 states.
The verdict
NCT07148414, a Phase 2 study of Rheumatoid Arthritis and Psoriatic Arthritis, is actively recruiting participants, sponsored by Spyre Therapeutics.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 285 participants
- Enrollment target
- 20
- Study locations
Study Summary
This is a multi-center, double-blind, placebo-controlled, Phase 2, proof-of-concept basket study with the goal of assessing the efficacy and safety of SPY072 compared to placebo in adults (aged ≥18 years) with rheumatic disease (RD).
Conditions Studied
Interventions
- DRUG Placebo
- DRUG SPY002-072
Study Locations (20)
California
- Site 114 - Chula Vista
- Site 111 - Covina
- Site 108 - Tujunga
- Site 112 - Upland
- Site 107 - Whittier
Florida
- Site 109 - Hialeah
- Site 106 - Ormond Beach
- Site 110 - Tampa
Texas
- Site 105 - Corpus Christi
- Site 103 - Tomball
- Site 102 - Tomball
Plovdiv
- Site 506 - Plovdiv
- Site 505 - Plovdiv
Arizona
- Site 113 - Avondale
Pennsylvania
- Site 104 - Duncansville
Lovech
- Site 503 - Lovech
Pleven
- Site 502 - Pleven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 285 participants |
| Start Date | 2025-08-21 |
| Est. Completion | 2028-03-31 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07148414
The ClinicalTrials.gov registry entry for NCT07148414 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 285 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 4,689-participant average among 197 other Rheumatoid Arthritis trials with a reported enrollment target (94% lower). The listed sponsor is Spyre Therapeutics, which has 6 total studies on file at ClinicalTrials.gov.
The record links to 8 conditions, with Rheumatoid Arthritis appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT07148414 reports 20 study locations spanning 11 distinct geographic areas - top geographies include California, Florida, Texas.
Frequently Asked Questions
What is clinical trial NCT07148414 about?
NCT07148414 is a clinical study titled "A Study of SPY072 in Rheumatic Disease". This is a multi-center, double-blind, placebo-controlled, Phase 2, proof-of-concept basket study with the goal of assessing the efficacy and safety of SPY072 compared to placebo in adults (aged ≥18 years) with rheumatic disease (RD).
What is the current status of trial NCT07148414?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 285 participants. The study started on 2025-08-21. Estimated completion is 2028-03-31.
What conditions does trial NCT07148414 study?
This clinical trial studies the following conditions: Rheumatoid Arthritis, Psoriatic Arthritis, Rheumatic Diseases, Axial Spondyloarthritis, Rheumatologic Disease.
What interventions are being tested in trial NCT07148414?
The interventions under investigation include: Placebo (DRUG), SPY002-072 (DRUG).
Who is sponsoring clinical trial NCT07148414?
This trial is sponsored by Spyre Therapeutics, which has 6 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07148414 being conducted?
This trial has 20 study locations across Arizona, California, Florida, Pennsylvania, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Rheumatoid Arthritis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
Dynamic Treatment Regiments for Glucocorticoid Tapering
RECRUITING · Phase 2
-
A Study to Investigate Efficacy and Safety of AZD1163 in Participants With Rheumatoid Arthritis
RECRUITING · Phase 2
-
A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis
RECRUITING · Phase 2
-
A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)
RECRUITING · Phase 2
-
An Adaptive Phase 2a/2b Study of LY3871801 in Adult Participants With Rheumatoid Arthritis
RECRUITING · Phase 2
-
A Study of Efficacy and Safety of Rosnilimab in Subjects with Moderate to Severe Rheumatoid Arthritis (RENOIR)
ACTIVE NOT RECRUITING · Phase 2
Explore more on PlainTrial
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.