Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06093906 · ClinicalTrials.gov registry record · NA
Positive Processes and Transition to Health (PATH)
A NA study of Major Depressive Disorder and Post Traumatic Stress Disorder, sponsored by Case Western Reserve University.
- Recruiting
- Registry status
- NA
- Development phase
- 135
- Enrollment target
- 3
- Study locations
NCT06093906: Recruiting NA study of Major Depressive Disorder and Post Traumatic Stress Disorder, sponsored by Case Western Reserve University.
NCT06093906 is a NA study of Major Depressive Disorder and Post Traumatic Stress Disorder that is actively recruiting participants, run by Case Western Reserve University. The registered enrollment target is 135 participants, below the 376-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (64% lower). The trial reports 3 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06093906, a NA study of Major Depressive Disorder and Post Traumatic Stress Disorder, is actively recruiting participants, sponsored by Case Western Reserve University.
- RECRUITING
- Registry status
- NA
- Development phase
- 135 participants
- Enrollment target
- 3
- Study locations
Study Summary
The R33 will be a randomized controlled trial to replicate changes in the targets (unproductive processing, avoidance, reward deficits) from the R61 phase in a larger sample of 135 participants who have experienced a destabilizing life event involving profound loss or threat, report persistent stressor-related symptoms of PTSD and/or depression, and are elevated on symptoms related to 2 of the 3 therapeutic targets. Additionally, this study will examine Positive Processes and Transition to Health (PATH)'s impact on stressor-related psychopathology in comparison to Progressive Muscle Relaxation (PMR). In the R33 phase, the investigators will examine changes in target mechanisms predicting improvements in PTSD and depressive symptoms, as well as feasibility and acceptability. Patients will receive 6 sessions of PATH or PMR (with 2 boosters, if partial responders). Primary targets will be assessed at pre-treatment, week 3, post-treatment, and at 1- and 3-month follow-up; secondary targets at pre-treatment, weekly during treatment, post-treatment, and at 1- and 3-month follow-ups.
Primary Outcome
Measure updating of affective information in working memory
Conditions Studied
Interventions
- BEHAVIORAL Positive Processes and Transition to Health
- BEHAVIORAL Progressive Muscle Relaxation
Study Locations (3)
Delaware
- University of Delaware - Newark
Ohio
- Case Western Reserve University - Cleveland
Washington
- University of Washington - Seattle
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 135 participants |
| Start Date | 2023-09-12 |
| Est. Completion | 2026-06-30 |
| Phase | NA |
What NCT06093906 shows while recruiting
NCT06093906 is an interventional study that assigns participants to a tested intervention. The registered 135 participants enrollment target is mid-sized for trials with a published cap, below the 376-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (64% lower).
The record links to 2 conditions, with Major Depressive Disorder appearing as the primary indexed condition, and to 2 interventions - of which Positive Processes and Transition to Health is the first listed.
NCT06093906 reports a single indexed study location in Delaware, Ohio, Washington.
Frequently Asked Questions
What is clinical trial NCT06093906 about?
NCT06093906 is a clinical study titled "Positive Processes and Transition to Health (PATH)". The R33 will be a randomized controlled trial to replicate changes in the targets (unproductive processing, avoidance, reward deficits) from the R61 phase in a larger sample of 135 participants who have experienced a destabilizing life event involving profound loss or threat, report persistent stres...
What is the current status of trial NCT06093906?
This trial is currently recruiting. It is a NA study. The enrollment target is 135 participants. The study started on 2023-09-12. Estimated completion is 2026-06-30.
What conditions does trial NCT06093906 study?
This clinical trial studies the following conditions: Major Depressive Disorder, Post Traumatic Stress Disorder.
What interventions are being tested in trial NCT06093906?
The interventions under investigation include: Positive Processes and Transition to Health (BEHAVIORAL), Progressive Muscle Relaxation (BEHAVIORAL).
Who is sponsoring clinical trial NCT06093906?
This trial is sponsored by Case Western Reserve University, which has 141 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06093906 being conducted?
This trial has 3 study locations across Delaware, Ohio, Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Major Depressive Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06093906's enrollment target sits among peer trials
135 110th of 282 higher than 173 of 282 other Major Depressive Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Major Depressive Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Taking Action for College Students
RECRUITING · NA
-
Targeting Large-scale Networks in Depression With Real-time Functional Magnetic Resonance Imaging (fMRI) Neurofeedback
RECRUITING · NA
-
Neural Correlates of Stress and Perceived Control in Adolescent Depression
RECRUITING · NA
-
Getting Out of the House: Using Behavioral Activation to Increase Community Participation
RECRUITING · NA
-
Amygdala Neurofeedback for Depression - Large Scale Clinical Trial
RECRUITING · NA
-
Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00870129 · 135 participants · NA
Magnetic Resonance (MR) Imaging to Determine High Risk Areas in Patients With Malignant Gliomas and to Design Potential Radiation Plans and to Examine Metabolite Changes in Gliomas and Other Solid Tumors
- NCT03666000 · 135 participants · Phase 1
Dose-escalation and Dose-expansion Study of Safety of Azer-cel (PBCAR0191) in Participants With Relapsed/Refractory (r/r) Non-Hodgkin Lymphoma (NHL) and r/r B-cell Acute Lymphoblastic Leukemia (B-ALL)
- NCT04891510 · 135 participants · NA
A Comparative Analysis of REVOLVE, LipoGrafter, and Viality in Autologous Fat Grafting During Breast Surgery
- NCT05121051 · 135 participants · Phase 2
Testing the Effect of the Broccoli Seed and Sprout Extract, Avmacol ES, on the Cancer Causing Substances of Tobacco in Heavy Smokers
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI