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NCT06990191 · ClinicalTrials.gov registry record · NA
A Hybrid 1 Effectiveness-Implementation Trial of Partner-Assisted Prolonged Exposure for PTSD
A NA study of Post Traumatic Stress Disorder, sponsored by United States Department of Defense.
- Recruiting
- Registry status
- NA
- Development phase
- 420
- Enrollment target
- 4
- Study locations
NCT06990191 is a NA study of Post Traumatic Stress Disorder that is actively recruiting participants, run by United States Department of Defense. The registered enrollment target is 420 participants, below the 1,114-participant average among 144 other Post Traumatic Stress Disorder trials with a reported enrollment target (62% lower). The trial reports 4 study locations across 4 states.
The verdict
NCT06990191, a NA study of Post Traumatic Stress Disorder, is actively recruiting participants, sponsored by United States Department of Defense.
- RECRUITING
- Registry status
- NA
- Development phase
- 420 participants
- Enrollment target
- 4
- Study locations
Study Summary
PTSD occurs in up to 17% of post-9/11 US Service Members and is associated with long-term functional impairment, family problems, unemployment, and suicidality. Trauma-focused therapies (TFTs), such as Prolonged Exposure (PE), result in significant relief for many. Yet, TFTs are not equally effective for everyone. An important minority (\~40%) will retain their PTSD diagnoses after treatment, and many discontinue treatment prematurely, especially post-9/11 Service Members. TFTs are also more effective in addressing symptoms than psychosocial functioning. More work is needed to improve the consistency and potency of TFTs. Partnering with significant others may provide a powerful method for helping individuals get more out of their PTSD treatment. Observational research shows that relationship factors can help patients initiate, stay in, and experience greater benefit from PTSD treatment. Veterans that were surveyed experienced greater treatment gains when they shared more about their treatment with loved ones and when loved ones accommodated less for PTSD symptoms. Despite the promise of partner-involved interventions, there is no couples approach to PTSD treatment that has demonstrated superior outcomes to individual-only treatment models (i.e., TFTs). To address this gap, the investigators have completed a series of partner-assisted PTSD treatment studies, leading up the current proposal (Partnered PE, PPE). The investigators found that treatment completion rates were better than routine clinical care, and the treatment led to large improvements in participants' functioning, PTSD symptoms, and romantic functioning. For this proposed study, the primary objective is to conduct a randomized controlled trial (Research Level 3; larger-scale clinical trial) to test the superiority of PPE to standard PE among post 9/11 Veterans. The investigator's primary hypothesis is that PPE will lead to greater improvements in psychosocial functioning than standard PE. Secondary and t
Conditions Studied
Interventions
- BEHAVIORAL Partnered Prolonged Exposure (PPE)
- BEHAVIORAL Prolonged Exposure (PE)
Study Locations (4)
Arizona
- Phoenix VA Healthcare System - Phoenix
California
- San Diego VA Healthcare System - San Diego
Minnesota
- Minneapolis VA Healthcare System - Minneapolis
South Carolina
- Charleston VA Healthcare System - Charleston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 420 participants |
| Start Date | 2025-05-16 |
| Est. Completion | 2028-08-31 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06990191
The ClinicalTrials.gov registry entry for NCT06990191 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 420 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 1,114-participant average among 144 other Post Traumatic Stress Disorder trials with a reported enrollment target (62% lower). The listed sponsor is United States Department of Defense, which has 13 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Post Traumatic Stress Disorder appearing as the primary indexed condition, and to 2 interventions - of which Partnered Prolonged Exposure (PPE) is the first listed.
NCT06990191 reports 4 study locations spanning 4 distinct geographic areas - top geographies include Arizona, California, Minnesota.
Frequently Asked Questions
What is clinical trial NCT06990191 about?
NCT06990191 is a clinical study titled "A Hybrid 1 Effectiveness-Implementation Trial of Partner-Assisted Prolonged Exposure for PTSD". PTSD occurs in up to 17% of post-9/11 US Service Members and is associated with long-term functional impairment, family problems, unemployment, and suicidality. Trauma-focused therapies (TFTs), such as Prolonged Exposure (PE), result in significant relief for many. Yet, TFTs are not equally effectiv...
What is the current status of trial NCT06990191?
This trial is currently recruiting. It is a NA study. The enrollment target is 420 participants. The study started on 2025-05-16. Estimated completion is 2028-08-31.
What conditions does trial NCT06990191 study?
This clinical trial studies the following conditions: Post Traumatic Stress Disorder.
What interventions are being tested in trial NCT06990191?
The interventions under investigation include: Partnered Prolonged Exposure (PPE) (BEHAVIORAL), Prolonged Exposure (PE) (BEHAVIORAL).
Who is sponsoring clinical trial NCT06990191?
This trial is sponsored by United States Department of Defense, which has 13 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06990191 being conducted?
This trial has 4 study locations across Arizona, California, Minnesota, South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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