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ClinicalTrials.gov 40 recruiting now official registry

Parkinson's Disease clinical trials

40 of 159 indexed Parkinson's Disease trials are currently recruiting.

159 US clinical trials · 40 currently recruiting

Parkinson's Disease is the subject of 159 registered US clinical trials on ClinicalTrials.gov, 40 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 55 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 16 of these trials.

The research picture

Parkinson's Disease has 159 registered US clinical trials, 40 of them open to new participants right now, about 25% of the total.

40
recruiting participants now
25%
of trials open to enrollment
21
in Phase 3–4 (later-stage)
16
top sponsor: VA Office of Research and Development
Phase 124Phase 231Phase 311Phase 410

Active & Recent Trials

159 total, page 1 of 4

RECRUITING 25,000 participants

Parkinson's Foundation PD GENEration Genetic Registry

Parkinson's Foundation

NCT04994015

RECRUITING 5,000 participants

Physiological Brain Atlas Development

Vanderbilt University Medical Center

NCT00575081

RECRUITING 5,000 participants

The Parkinson's Genetic Research Study

University of Washington

NCT01558479

RECRUITING 4,000 participants

Natural History Protocol for Movement Disorders

National Institute of Neurological Disorders and Stroke (NINDS)

NCT05413291

RECRUITING 2,000 participants

Retinal Imaging in Neurodegenerative Disease

Duke University

NCT03233646

RECRUITING 2,000 participants

Modifiable Variables in Parkinsonism (MVP)

Bastyr University

NCT02194816

RECRUITING 1,500 participants

Registry of Deep Brain Stimulation With the VERCISE™ System: Vercise DBS Registry

Boston Scientific Corporation

NCT02071134

RECRUITING Phase 3 900 participants

A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease

Hoffmann-La Roche

NCT07174310

RECRUITING 430 participants

Parkinson's Disease in Asian Americans

Tufts University

NCT05532982

RECRUITING NA 300 participants

Deep Brain Stimulation Therapy in Movement Disorders

National Institute of Neurological Disorders and Stroke (NINDS)

NCT02119611

RECRUITING NA 200 participants

Deep Brain Stimulation Surgery for Movement Disorders

National Institute of Neurological Disorders and Stroke (NINDS)

NCT01581580

RECRUITING Phase 1 184 participants

PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease

National Institute of Mental Health (NIMH)

NCT04396873

RECRUITING NA 180 participants

Sensory-specific Peripheral Stimulation for Tremor Management

Shirley Ryan AbilityLab

NCT04501133

RECRUITING NA 166 participants

Telemedicine Intervention in Patients With Chronic Pain in PD

VA Office of Research and Development

NCT05410392

RECRUITING 120 participants

Gait Analysis in Neurological Disease

Beth Israel Deaconess Medical Center

NCT02994719

RECRUITING Phase 2 120 participants

Imaging Depression in Parkinson's Disease

Yale University

NCT06402955

RECRUITING Phase 1 108 participants

A Clinical Trial of LY3962681 in Healthy Volunteers and in Patients With Parkinson's Disease

Prevail Therapeutics

NCT06565195

RECRUITING 100 participants

Kinematic and Neural Dynamics of Postural Instability in Parkinson's Disease

VA Office of Research and Development

NCT06405334

RECRUITING 100 participants

Udall Project 1 Aim 4

University of Minnesota

NCT05568199

RECRUITING Phase 2 80 participants

Ketamine for Veterans With Parkinson's Disease

VA Office of Research and Development

NCT06231563

RECRUITING 76 participants

Distinguishing Between Alzheimer's Disease, Lewy Body Dementia, and Parkinson's Disease

Douglas Scharre

NCT03019757

RECRUITING NA 72 participants

Remote Dynamic Cycling for the Customized Off-site Rehab in Parkinson's Disease

VA Office of Research and Development

NCT05298150

RECRUITING Phase 2 60 participants

Evaluation of Tau-Pathology in Sporadic and LRRK2 Parkinson's Disease

Michael J. Fox Foundation for Parkinson's Research

NCT07020026

RECRUITING 60 participants

A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Pallidotomy for the Treatment of Advanced, Idiopathic Parkinson's Disease With Medication-refractory Moderate to Severe Motor Complications

InSightec

NCT05539196

RECRUITING Phase 1 56 participants

rTMS to Improve Cognition in Parkinson's

VA Office of Research and Development

NCT03836950

RECRUITING NA 50 participants

Speech Learning and Speech Production in Parkinson's Disease

State University of New York at Buffalo

NCT07403539

RECRUITING 40 participants

Deep Brain Stimulation for Visuomotor Function in Parkinson's Disease

VA Office of Research and Development

NCT05400499

RECRUITING Early Phase 1 40 participants

PET Imaging Evaluation of [11C]SY08

Massachusetts General Hospital

NCT06098612

RECRUITING NA 40 participants

Efficacy of a Breathwork Practice (SKY) on Well-Being of Individuals With Parkinson's Disease (iPD) and Care Partners

Nova Southeastern University

NCT06581523

RECRUITING NA 30 participants

Feasibility and Safety of a Portable Exoskeleton to Improve Mobility in Parkinson's Disease

VA Office of Research and Development

NCT06028529

RECRUITING Phase 2 30 participants

Tenapanor in Synucleinopathy-Related Constipation

Cedar Valley Digestive Health Center

NCT06460038

RECRUITING NA 30 participants

Patterned Multichannel Vibrotactile Stimulation for the Longitudinal Treatment of Moderate Stage Parkinson's Disease

Synergic Medical Technologies

NCT05830110

RECRUITING Phase 1 25 participants

A Multicenter Study to Evaluate Safety, Tolerability, and Clinical Responses of DSP-1083 Into Subjects With Parkinson's Disease

Sumitomo Pharma America

NCT06753331

RECRUITING NA 24 participants

Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease

University of Minnesota

NCT05557864

RECRUITING Phase 1 24 participants

A Study to Evaluate Feasibility, Safety, and Clinical Responses of Implanting Autologous Peripheral Nerve Tissue Into the Brain for Non-motor or Motor Symptoms in Patients With Parkinson's Disease Undergoing DBS Surgery

Craig van Horne, MD, PhD

NCT06683378

RECRUITING Early Phase 1 22 participants

Open-label Study to Evaluate Brain α-Synuclein Deposition Using PET and [18F]MK-0947 in Parkinson's Disease

Invicro

NCT07348250

RECRUITING NA 20 participants

Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease (Aim 2)

University of Nebraska

NCT05070013

RECRUITING NA 10 participants

Novel DBS Stimulation Patterns for Treatment of Parkinson's Disease

University of Nebraska

NCT04799470

RECRUITING NA 10 participants

Combined STN and NBM Deep Brain Stimulation for Mild Cognitive Impairment in Parkinson's Disease

Helen M. Bronte-Stewart

NCT05968703

RECRUITING Phase 1 7 participants

Autologous suraL nervE Grafting to the Substantia nigrA in Patients With Synuclienopathies

Craig van Horne, MD, PhD

NCT06683365

ACTIVE NOT RECRUITING 25,000 participants

Rostock International Parkinson's Disease Study (ROPAD)

CENTOGENE GmbH Rostock

NCT03866603

ACTIVE NOT RECRUITING Phase 2 586 participants

A Study to Evaluate the Efficacy and Safety of Intravenous Prasinezumab in Participants With Early Parkinson's Disease

Hoffmann-La Roche

NCT04777331

ACTIVE NOT RECRUITING 500 participants

Global Registry: ExAblate Neuro MR Guided Focused Ultrasound (MRgFUS) of Neurological Disorders:

InSightec

NCT03100474

ACTIVE NOT RECRUITING Phase 3 381 participants

Efficacy, Safety and Tolerability Study of ND0612 vs. Oral Immediate Release Levodopa/Carbidopa (IR-LD/CD) in Subjects With Parkinson's Disease Experiencing Motor Fluctuations

NeuroDerm

NCT04006210

ACTIVE NOT RECRUITING 320 participants

PET Imaging in Parkinson Disease Dementia

Washington University School of Medicine

NCT01052350

ACTIVE NOT RECRUITING Phase 2 316 participants

A Study to Evaluate the Efficacy of Prasinezumab (RO7046015/PRX002) in Participants With Early Parkinson's Disease

Hoffmann-La Roche

NCT03100149

ACTIVE NOT RECRUITING Phase 2 237 participants

Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD

Bial R&D Investments, S.A.

NCT05819359

ACTIVE NOT RECRUITING Phase 2 214 participants

A Long Term Safety Study of ND0612 Administered as a Continuous SC Infusion in Advanced Parkinson's Disease

NeuroDerm

NCT02726386

ACTIVE NOT RECRUITING 194 participants

Noninterventional Study Evaluating Parkinson's Disease Diary Use

BlueRock Therapeutics

NCT05363046

ACTIVE NOT RECRUITING 150 participants

Pre-Gene Therapy Study in Parkinson's Disease and Multiple System Atrophy

AskBio

NCT05699460

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Phase Distribution

PhaseTrial count
Phase 1 24
Phase 2 31
Phase 3 11
Phase 4 10

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Parkinson's Disease Trial Landscape

159 indexed Parkinson's Disease studies · 40 recruiting (25%).

Phase mix: 21 late (III/IV) vs 55 early (I/II).

Top sponsor: VA Office of Research and Development (16 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Parkinson's Disease?

PlainTrial tracks 159 US clinical trials for Parkinson's Disease, of which 40 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Parkinson's Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.