Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04799470 · ClinicalTrials.gov registry record · NA
Novel DBS Stimulation Patterns for Treatment of Parkinson's Disease
A NA study of Parkinson's Disease, sponsored by University of Nebraska.
- Recruiting
- Registry status
- NA
- Development phase
- 10
- Enrollment target
- 1
- Study location
NCT04799470: Recruiting NA study of Parkinson's Disease, sponsored by University of Nebraska.
NCT04799470 is a NA study of Parkinson's Disease that is actively recruiting participants, run by University of Nebraska. The registered enrollment target is 10 participants, below the 635-participant average among 158 other Parkinson's Disease trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04799470, a NA study of Parkinson's Disease, is actively recruiting participants, sponsored by University of Nebraska.
- RECRUITING
- Registry status
- NA
- Development phase
- 10 participants
- Enrollment target
- 1
- Study location
Study Summary
This is an open-label, non-randomized, proof-of-concept comparison of clinical vs. research stimulation patterns in patients with Parkinson's disease (PD) being treated with Deep Brain Stimulation (DBS) through the Medtronic Percept PC DBS device. The investigators hypothesize that stimulation patterns designed to better target excessive synchrony in a patient-tailored manner may result in more efficient and effective therapy with fewer side effects. Medtronic 3rd-generation sensing implantable neural stimulator, Percept PC, is FDA-approved for treating PD. The Percept PC device features BrainSense, the first and only available sensing technology for deep brain stimulation. BrainSense technology allows the device to capture and record brain signals (local field potentials, or LFP) using the brain-implanted DBS lead, while simultaneously delivering therapeutic stimulation. Investigators plan to enroll and complete investigations in 15 study subjects total, who have been previously implanted with the Medtronic Percept PC for the treatment of PD, and who are optimized for clinical stimulation and anti-Parkinsons medication. Investigations will be performed in UNMC Movement Disorders Clinic, UNMC Neurosurgery Lab, and UNO Biomechanics Research Building, Gait Lab. Subjects will receive research stimulation patterns and the effect on PD motor symptoms will be assessed via Unified Parkinsons Disease Rating Scale (UPDRS)-part III and gait measures. Videotaping of patient UPDRS-III testing and gait will be obtained.
Primary Outcome
To assess if the novel stimulation patterns provide similar side effect profile, when compared to standard clinical stimulation, tolerability will be assessed by: 1. Number of study participants experiencing stimulation-related side effects. Side effects will be measured as patient-reported severity and type of side effect. 2. Number of study participants experiencing stimulation-related Adverse Events.
Conditions Studied
Interventions
- DEVICE Novel DBS stimulation patterns
Study Locations (1)
Nebraska
- Unversity of Nebraska Medical Center - Omaha
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2021-05-10 |
| Est. Completion | 2026-04 |
| Phase | NA |
What NCT04799470 shows while recruiting
NCT04799470 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 635-participant average among 158 other Parkinson's Disease trials with a reported enrollment target (98% lower).
The record links to 1 condition, with Parkinson's Disease appearing as the primary indexed condition, and to 1 intervention - of which Novel DBS stimulation patterns is the first listed.
NCT04799470 reports a single indexed study location in Nebraska.
Frequently Asked Questions
What is clinical trial NCT04799470 about?
NCT04799470 is a clinical study titled "Novel DBS Stimulation Patterns for Treatment of Parkinson's Disease". This is an open-label, non-randomized, proof-of-concept comparison of clinical vs. research stimulation patterns in patients with Parkinson's disease (PD) being treated with Deep Brain Stimulation (DBS) through the Medtronic Percept PC DBS device. The investigators hypothesize that stimulation patte...
What is the current status of trial NCT04799470?
This trial is currently recruiting. It is a NA study. The enrollment target is 10 participants. The study started on 2021-05-10. Estimated completion is 2026-04.
What conditions does trial NCT04799470 study?
This clinical trial studies the following conditions: Parkinson's Disease.
What interventions are being tested in trial NCT04799470?
The interventions under investigation include: Novel DBS stimulation patterns (DEVICE).
Who is sponsoring clinical trial NCT04799470?
This trial is sponsored by University of Nebraska, which has 407 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04799470 being conducted?
This trial has 1 study location across Nebraska. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Parkinson's Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04799470's enrollment target sits among peer trials
10 146th of 158 higher than 8 of 158 other Parkinson's Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Parkinson's Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Feasibility and Safety of a Portable Exoskeleton to Improve Mobility in Parkinson's Disease
RECRUITING · NA
-
Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease
RECRUITING · NA
-
Remote Dynamic Cycling for the Customized Off-site Rehab in Parkinson's Disease
RECRUITING · NA
-
Deep Brain Stimulation Therapy in Movement Disorders
RECRUITING · NA
-
Combined STN and NBM Deep Brain Stimulation for Mild Cognitive Impairment in Parkinson's Disease
RECRUITING · NA
-
Telemedicine Intervention in Patients With Chronic Pain in PD
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00623389 · 10 participants · NA
Evaluation of an Advanced Lower Extremity Neuroprostheses
- NCT01241864 · 10 participants · Phase 2
Islet Transplantation in Type 1 Diabetic Kidney Allograft
- NCT01293214 · 10 participants · NA
Vascularized Composite Allotransplantation for Multiple Extremity Amputations
- NCT01474148 · 10 participants · NA
A Neuroprosthesis for Seated Posture and Balance
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI