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Barrett's Esophagus: later-stage trial registry
6 of 23 indexed Barrett's Esophagus trials are currently recruiting, with more weight in Phase 3-4.
Corpus placement: #724 of 28,707 conditions by registered trial count.
23 US clinical trials · 6 currently recruiting · #724 of 28,707 conditions by registered trial count
Barrett's Esophagus: 23 US clinical trials tracked, 6 recruiting.
Barrett's Esophagus is the subject of 23 registered US clinical trials on ClinicalTrials.gov, 6 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is Mayo Clinic, running 5 of these trials.
Enrollment posture brief
Registry condition barretts-esophagus
OPEN 6 | RECR 26% | LATE 4 | EARLY 2 | RANK #724 | SPON 5
Volume-matched condition peers
Nearest open-share peer: Parkinson's Disease (26% recruiting · 161 trials)
Barrett's Esophagus lists 6 open slots (26% of 23 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Barrett's Esophagus on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Barrett's Esophagus is recruiting below its size-band peers.
6 of 23 indexed trials (26.1%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Barrett's Esophagus research.
Mayo Clinic accounts for 5 of 23 trials (21.7%). 13 distinct sponsors appear on at least one study for this condition label.
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Most Barrett's Esophagus trials plan to enrol fewer than 100 people.
Median target enrolment is 80 among the 23 trials that report a genuine target (sentinel values excluded). 14 of those (60.9%) plan for fewer than 100 participants.
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Barrett's Esophagus splits between interventional and observational designs.
12 interventional and 11 observational studies make up this index (52.2% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
23 total, page 1 of 1
TREAT-BE Study (Treatment With Resection and Endoscopic Ablation Techniques for Barrett's Esophagus)
University of Colorado, Denver
NCT02634645
Progression of Gastroesophageal Reflux Disease and Barrett's Esophagus and the Creation of a Barrett's Registry
Midwest Biomedical Research Foundation
NCT00574327
Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma
Case Western Reserve University
NCT00288119
Barrett's Esophagus Related Neoplasia (BERN) Project
Midwest Biomedical Research Foundation
NCT00590239
Pilot Study for TCE Imaging of the Esophagus Using an OFDI Capsule With a Compact Imaging System
Massachusetts General Hospital
NCT02947971
Navicam for Detection of Barrett's Esophagus
Mayo Clinic
NCT06748911
Surveillance and Image-Guided Biopsy of the Esophagus Using an OFDI Capsule
Massachusetts General Hospital
NCT02422433
Racial Disparity in Barrett's Esophagus
University of North Carolina, Chapel Hill
NCT01374074
Stratifying Risk in Barrett's Esophagus: A Pilot Study for Biomarker-based Patient Management
University of North Carolina, Chapel Hill
NCT02075905
Optical Coherence Tomography (OCT) Based Screening of Esophagus and Gastroesophageal Junction
Massachusetts General Hospital
NCT01401699
Is the Neosquamous Epithelium "Normal" Following Endoscopic Ablation of Dysplastic Barrett's Esophagus?
University of North Carolina, Chapel Hill
NCT01373125
Confocal Microscopy in Barrett's Esophagus
Mayo Clinic
NCT00587184
An Open Label pH Comparison of Esomeprazole and Lansoprazole in Barrett's Esophagus Patients
AstraZeneca
NCT00352261
BETERNet Notch Signaling and Novel Biomarkers for Barretts Esophagus
Abramson Cancer Center at Penn Medicine
NCT01484925
Modulation of Esophageal Inflammation in Barrett's Esophagus by Omega-3 Fatty Acids
Mayo Clinic
NCT01733147
Comparison of Treatments for Barrett's Esophagus With High-Grade Dysplasia/Early Adenocarcinoma
Massachusetts General Hospital
NCT01961778
Confocal Endomicroscopy for Barrett's Esophagus
Johns Hopkins University
NCT00487695
DCLK1 as a Marker/Indicator of Stem Cell Response in Barrett's Esophagus/Esophageal Adenocarcinoma
University of Oklahoma
NCT03526328
Endoscopic Multispectral Imaging for the Early Detection of Barrett's Neoplasia
Anandasabapathy, Sharmila, M.D.
NCT01384864
Trial to Assess the Effects of an Antimicrobial Mouthwash on the Esophageal Microbiome
Columbia University
NCT02513784
Acid Reflux and Stromal Fibroblasts in Barrett's Esophagus
Mayo Clinic
NCT00573911
Micro-RNA (miR) Expression in Upper Gastrointestinal Mucosal Tissue
Mayo Clinic
NCT00909350
Study of CryoSpray Ablation(TM)to Determine Treatment Effect, Depth of Injury, and Side Effects in the Esophagus.
CSA Medical
NCT00754468
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 3 | 1 |
| Phase 4 | 3 |
Top Sponsors
Named interventions
Most-linked intervention names on Barrett's Esophagus records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Barrett's Esophagus trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Barrett's Esophagus page
23 registered trials, 6 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 6 Barrett's Esophagus trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Mayo Clinic sponsors the most Barrett's Esophagus trials on record, review their full trial history before evaluating a specific study. See Mayo Clinic's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Barrett's Esophagus condition card totals 23 registered trials; most-linked intervention Radio-Frequency Ablation; top US site state Missouri. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.