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RECRUITING Phase 3

A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease

NCT07174310 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics (PK) of prasinezumab compared with placebo in participants with early-stage Parkinson's disease (PD) on stable symptomatic monotherapy with levodopa.

Conditions Studied

Interventions

  • DRUG Placebo
  • DRUG Prasinezumab

Study Locations (20)

Florida

  • JEM Research LLC — Atlantis
  • Parkinson's Disease and Movement Disorders Center of Boca Raton — Boca Raton
  • K2 - Villages — Lady Lake
  • K2 Medical Research-Maitland — Maitland
  • Charter Research - Winter Park/Orlando — Orlando

California

  • Neurology Center of North Orange County — Fullerton
  • Keck School of Medicine of USC — Los Angeles
  • Profound Research LLC at The Neurology Center of Southern California — Pasadena
  • UCSF Weill Institute for Neurosciences — San Francisco

New York

  • Dent Neurological Institute — Amherst
  • Weill Cornell Medical College — New York

Colorado

  • Rocky Mountain Movement Disorders — Englewood

Connecticut

  • Institute for Neurodegenerative Disorders — New Haven

Hawaii

  • Hawaii Pacific Neuroscience — Honolulu

Michigan

  • Quest Research Institute — Farmington Hills

Nevada

  • Renown Health — Reno

Trial Details

FieldValue
Enrollment Target 900 participants
Start Date 2025-11-24
Est. Completion 2031-06-30
Phase Phase 3

Sponsor

Hoffmann-La Roche

758 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07174310

The ClinicalTrials.gov registry entry for NCT07174310 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 900 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Hoffmann-La Roche, which has 758 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Parkinson's Disease appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07174310 reports 20 study locations spanning 12 distinct geographic areas — top geographies include Florida, California, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07174310 about?

NCT07174310 is a clinical study titled "A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease". The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics (PK) of prasinezumab compared with placebo in participants with early-stage Parkinson's disease (PD) on stable symptomatic monotherapy with levodopa.

What is the current status of trial NCT07174310?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 900 participants. The study started on 2025-11-24. Estimated completion is 2031-06-30.

What conditions does trial NCT07174310 study?

This clinical trial studies the following conditions: Parkinson's Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07174310?

The interventions under investigation include: Placebo (DRUG), Prasinezumab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07174310?

This trial is sponsored by Hoffmann-La Roche, which has 758 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07174310 being conducted?

This trial has 20 study locations across California, Colorado, Connecticut, Florida, Hawaii. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial