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ClinicalTrials.gov 40 recruiting now official registry

Parkinson's Disease clinical trials

40 of 159 indexed Parkinson's Disease trials are currently recruiting.

159 US clinical trials · 40 currently recruiting

Parkinson's Disease is the subject of 159 registered US clinical trials on ClinicalTrials.gov, 40 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 55 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 16 of these trials.

The research picture

Parkinson's Disease has 159 registered US clinical trials, 40 of them open to new participants right now, about 25% of the total.

40
recruiting participants now
25%
of trials open to enrollment
21
in Phase 3–4 (later-stage)
16
top sponsor: VA Office of Research and Development
Phase 124Phase 231Phase 311Phase 410

Active & Recent Trials

159 total, page 2 of 4

ACTIVE NOT RECRUITING 100 participants

The Parkinson's Disease NeuroGenebank at Scripps Clinic Registry

Scripps Translational Science Institute

NCT00766948

ACTIVE NOT RECRUITING 89 participants

Clinical Laboratory Evaluation of Chronic Autonomic Failure

National Institute of Neurological Disorders and Stroke (NINDS)

NCT03648905

ACTIVE NOT RECRUITING NA 82 participants

Partnered Dance Aerobic Exercise as a Neuroprotective, Motor and Cognitive Intervention in Parkinson's Disease

VA Office of Research and Development

NCT04122690

ACTIVE NOT RECRUITING Phase 1 70 participants

Cont. of a Study to Evaluate Implanting Peripheral Nerve Grafts Into Subjects With Parkinson's Disease (PD) During DBS

Craig van Horne, MD, PhD

NCT02369003

ACTIVE NOT RECRUITING NA 65 participants

Bright Light Therapy for Non-motor Symptoms in Parkinson's Disease

Massachusetts General Hospital

NCT02909192

ACTIVE NOT RECRUITING 32 participants

Genotypic Influences on Network Progression in Parkinson's Disease

Northwell Health

NCT04228172

ACTIVE NOT RECRUITING Phase 1 13 participants

Long-term Follow-up of Glutamic Acid Decarboxylase (GAD) Gene Transfer in Parkinson's Disease

MeiraGTx

NCT05894343

ACTIVE NOT RECRUITING Phase 1 11 participants

GDNF Gene Therapy for Parkinson's Disease

Brain Neurotherapy Bio

NCT04167540

ACTIVE NOT RECRUITING Phase 1 10 participants

Feasibility and Safety of autoloGous UncondItioneD pEripheral Nerve Tissue Delivery to the Substantia Nigra (GUIDE)

Craig van Horne, MD, PhD

NCT05377281

ACTIVE NOT RECRUITING NA 7 participants

ExAblate Transcranial MRgFUS of the Subthalamic Nucleus for Treatment of Parkinson's Disease

InSightec

NCT02246374

COMPLETED 13,576 participants

Web-based Genetic Research on Parkinson's Disease

23andMe

NCT01351467

COMPLETED 750 participants

Consortium On Risk for Early-onset Parkinson's Disease (CORE PD)

Columbia University

NCT00104585

COMPLETED 684 participants

ADAGIO Follow Up Study: Evaluation of the Long-Term Effects of Rasagiline in Parkinson's Disease Subjects

Teva Branded Pharmaceutical Products R&D

NCT00936676

COMPLETED Phase 3 617 participants

An Open Label Extension Study of the Safety and Clinical Utility of IPX066 in Subjects With Parkinson's Disease

Impax Laboratories

NCT01096186

COMPLETED 600 participants

Diagnosis and Natural History Study of Patients With Neurological Conditions

National Institute of Neurological Disorders and Stroke (NINDS)

NCT00001549

COMPLETED Phase 3 514 participants

Trial to Assess Parkinson's Disease (PD) Symptom Control to Four Doses of Rotigotine in a Transdermal Patch

UCB Pharma

NCT00522379

COMPLETED 502 participants

PET Scanning in Parkinson s Disease

National Institute of Mental Health (NIMH)

NCT00024622

COMPLETED Phase 3 419 participants

An Open-label Continuation Study Evaluating the Long-term Safety of Extended Release Ropinirole XL (Formerly CR) in Parkinson''s Disease

GlaxoSmithKline

NCT00632736

COMPLETED 342 participants

Haptoglobin and Iron in Parkinson's Disease

Bastyr University

NCT02422992

COMPLETED Phase 4 328 participants

Rasagiline as Add on to Dopamine Agonists in the Treatment of Parkinson's Disease

Teva Neuroscience

NCT01049984

COMPLETED Phase 2 325 participants

12-Week, Double-Blind, Placebo-Controlled Study of 20 and 60 mg/Day Istradefylline in Parkinson's Disease Patients on Levodopa/Carbodopa

Kyowa Kirin

NCT00456794

COMPLETED Phase 3 298 participants

Study of Urate Elevation in Parkinson's Disease, Phase 3

Michael Alan Schwarzschild

NCT02642393

COMPLETED Phase 3 254 participants

Study to Evaluate the Safety and Tolerability of Rasagiline in Advanced Parkinson's Disease Patients

Teva Branded Pharmaceutical Products R&D

NCT00203164

COMPLETED Phase 2 210 participants

Pioglitazone in Early Parkinson's Disease

University of Rochester

NCT01280123

COMPLETED 204 participants

Compare Rates of Agreement Between Clinical Diagnosis and Visual Assessment of DaTscan™ Images in Non-Caucasian and Caucasian Subjects With Parkinson's Disease (PD) or Essential Tremor (ET)

GE Healthcare

NCT01952678

COMPLETED Phase 2 195 participants

National Institute of Neurological Disorders and Stroke (NINDS) Parkinson's Disease Neuroprotection Trial

University of Rochester

NCT00063193

COMPLETED Phase 2 180 participants

Safety and Efficacy Study of Fipamezole in Treatment of Motor Dysfunctions in Parkinson's Disease

Juvantia Pharma

NCT00559871

COMPLETED Phase 4 170 participants

Parallel-Group Study to Assess the Effect of Rasagiline on Cognition in Patients With Parkinson's Disease

Teva Branded Pharmaceutical Products R&D

NCT01723228

COMPLETED Phase 2 160 participants

A Study of Istradefylline (KW-6002) as Monotherapy in Parkinson's Disease (PD) Patients

Kyowa Kirin

NCT00199433

COMPLETED Phase 2 149 participants

Safety, Tolerability and Efficacy of Two Doses of Once Daily P2B001 in Subjects With Early Parkinson's Disease

Pharma Two B

NCT01968460

COMPLETED Phase 3 123 participants

Deep Brain Stimulation for Parkinson's Disease Trial

University of Minnesota

NCT00053625

COMPLETED NA 123 participants

Mobile Decision Support System for Nurse Management of Neuromodulation Therapy

University of Utah

NCT02474459

COMPLETED 120 participants

Neuroimaging Studies of Depression in Parkinson's Disease

Lee Blonder

NCT00518258

COMPLETED Phase 3 110 participants

A Study to Compare IPX066 and Carbidopa/Levodopa/Entacapone (CLE) Followed by an Open-Label Safety Study of IPX066

Impax Laboratories

NCT01130493

COMPLETED NA 110 participants

Cognitive Rehabilitation for PD

VA Office of Research and Development

NCT03335150

COMPLETED NA 104 participants

An RCT of a Telemedicine Intervention for Hypokinetic Dysarthria in PD

VA Office of Research and Development

NCT04617496

COMPLETED 100 participants

Defining a PD-specific Breath Fingerprint of Underlying Inflammatory and Neurodegenerative Processes

Emory University

NCT02749214

COMPLETED 100 participants

Innovative Measures of Speech and Swallowing Dysfunction in Neurological Disorders

Beth Israel Deaconess Medical Center

NCT02118805

COMPLETED NA 94 participants

Exercise, Brain Imaging, Cognition, and Gait in Parkinsonism

Oregon Health and Science University

NCT02231073

COMPLETED Phase 2 80 participants

Valerian to Improve Sleep in Patients With Parkinson's Disease

National Center for Complementary and Integrative Health (NCCIH)

NCT00070928

COMPLETED 74 participants

Executive, Activities of Daily Living, and Cholinergic Functions in Parkinson's Disease

University of Michigan

NCT00737217

COMPLETED Phase 4 68 participants

Validation of Dyskinesia Rating Scales

Rush University Medical Center

NCT01071395

COMPLETED 67 participants

Imaging Biomarkers of Progression of Mobility Impairment in Parkinson Disease

VA Office of Research and Development

NCT01106976

COMPLETED Phase 2 64 participants

Early Parkinson's Disease Monotherapy With CVN424

Cerevance Beta

NCT06006247

COMPLETED Phase 1 64 participants

A Study to Assess the Pharmacokinetics, Safety, and Tolerability of Single and Multiple Doses of Rasagiline

Teva Branded Pharmaceutical Products R&D

NCT01879748

COMPLETED Phase 1 62 participants

A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of BIIB094 in Adults With Parkinson's Disease

Ionis Pharmaceuticals

NCT03976349

COMPLETED Phase 2 61 participants

Safety and Efficacy of DA-9805 for Parkinson's Disease

Dong-A ST Co.

NCT03189563

COMPLETED 58 participants

Diagnosis of PD and PD Progression Using DWI

University of Alabama at Birmingham

NCT02837172

COMPLETED Phase 2 51 participants

Ketamine for the Treatment of Depression in Parkinson's Disease

Yale University

NCT04944017

COMPLETED Phase 2 51 participants

A Study to Assess Safety and Tolerability of Oral AZD3241 in Patients With Parkinson's Disease

AstraZeneca

NCT01603069

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Phase Distribution

PhaseTrial count
Phase 1 24
Phase 2 31
Phase 3 11
Phase 4 10

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Parkinson's Disease Trial Landscape

159 indexed Parkinson's Disease studies · 40 recruiting (25%).

Phase mix: 21 late (III/IV) vs 55 early (I/II).

Top sponsor: VA Office of Research and Development (16 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Parkinson's Disease?

PlainTrial tracks 159 US clinical trials for Parkinson's Disease, of which 40 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Parkinson's Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.