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Parkinson's Disease clinical trials
40 of 159 indexed Parkinson's Disease trials are currently recruiting.
159 US clinical trials · 40 currently recruiting
Parkinson's Disease is the subject of 159 registered US clinical trials on ClinicalTrials.gov, 40 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 55 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 16 of these trials.
The research picture
Parkinson's Disease has 159 registered US clinical trials, 40 of them open to new participants right now, about 25% of the total.
- 40
- recruiting participants now
- 25%
- of trials open to enrollment
- 21
- in Phase 3–4 (later-stage)
- 16
- top sponsor: VA Office of Research and Development
Active & Recent Trials
159 total, page 2 of 4
The Parkinson's Disease NeuroGenebank at Scripps Clinic Registry
Scripps Translational Science Institute
NCT00766948
Clinical Laboratory Evaluation of Chronic Autonomic Failure
National Institute of Neurological Disorders and Stroke (NINDS)
NCT03648905
Partnered Dance Aerobic Exercise as a Neuroprotective, Motor and Cognitive Intervention in Parkinson's Disease
VA Office of Research and Development
NCT04122690
Cont. of a Study to Evaluate Implanting Peripheral Nerve Grafts Into Subjects With Parkinson's Disease (PD) During DBS
Craig van Horne, MD, PhD
NCT02369003
Bright Light Therapy for Non-motor Symptoms in Parkinson's Disease
Massachusetts General Hospital
NCT02909192
Genotypic Influences on Network Progression in Parkinson's Disease
Northwell Health
NCT04228172
Long-term Follow-up of Glutamic Acid Decarboxylase (GAD) Gene Transfer in Parkinson's Disease
MeiraGTx
NCT05894343
GDNF Gene Therapy for Parkinson's Disease
Brain Neurotherapy Bio
NCT04167540
Feasibility and Safety of autoloGous UncondItioneD pEripheral Nerve Tissue Delivery to the Substantia Nigra (GUIDE)
Craig van Horne, MD, PhD
NCT05377281
ExAblate Transcranial MRgFUS of the Subthalamic Nucleus for Treatment of Parkinson's Disease
InSightec
NCT02246374
Web-based Genetic Research on Parkinson's Disease
23andMe
NCT01351467
Consortium On Risk for Early-onset Parkinson's Disease (CORE PD)
Columbia University
NCT00104585
ADAGIO Follow Up Study: Evaluation of the Long-Term Effects of Rasagiline in Parkinson's Disease Subjects
Teva Branded Pharmaceutical Products R&D
NCT00936676
An Open Label Extension Study of the Safety and Clinical Utility of IPX066 in Subjects With Parkinson's Disease
Impax Laboratories
NCT01096186
Diagnosis and Natural History Study of Patients With Neurological Conditions
National Institute of Neurological Disorders and Stroke (NINDS)
NCT00001549
Trial to Assess Parkinson's Disease (PD) Symptom Control to Four Doses of Rotigotine in a Transdermal Patch
UCB Pharma
NCT00522379
PET Scanning in Parkinson s Disease
National Institute of Mental Health (NIMH)
NCT00024622
An Open-label Continuation Study Evaluating the Long-term Safety of Extended Release Ropinirole XL (Formerly CR) in Parkinson''s Disease
GlaxoSmithKline
NCT00632736
Haptoglobin and Iron in Parkinson's Disease
Bastyr University
NCT02422992
Rasagiline as Add on to Dopamine Agonists in the Treatment of Parkinson's Disease
Teva Neuroscience
NCT01049984
12-Week, Double-Blind, Placebo-Controlled Study of 20 and 60 mg/Day Istradefylline in Parkinson's Disease Patients on Levodopa/Carbodopa
Kyowa Kirin
NCT00456794
Study of Urate Elevation in Parkinson's Disease, Phase 3
Michael Alan Schwarzschild
NCT02642393
Study to Evaluate the Safety and Tolerability of Rasagiline in Advanced Parkinson's Disease Patients
Teva Branded Pharmaceutical Products R&D
NCT00203164
Pioglitazone in Early Parkinson's Disease
University of Rochester
NCT01280123
Compare Rates of Agreement Between Clinical Diagnosis and Visual Assessment of DaTscan™ Images in Non-Caucasian and Caucasian Subjects With Parkinson's Disease (PD) or Essential Tremor (ET)
GE Healthcare
NCT01952678
National Institute of Neurological Disorders and Stroke (NINDS) Parkinson's Disease Neuroprotection Trial
University of Rochester
NCT00063193
Safety and Efficacy Study of Fipamezole in Treatment of Motor Dysfunctions in Parkinson's Disease
Juvantia Pharma
NCT00559871
Parallel-Group Study to Assess the Effect of Rasagiline on Cognition in Patients With Parkinson's Disease
Teva Branded Pharmaceutical Products R&D
NCT01723228
A Study of Istradefylline (KW-6002) as Monotherapy in Parkinson's Disease (PD) Patients
Kyowa Kirin
NCT00199433
Safety, Tolerability and Efficacy of Two Doses of Once Daily P2B001 in Subjects With Early Parkinson's Disease
Pharma Two B
NCT01968460
Deep Brain Stimulation for Parkinson's Disease Trial
University of Minnesota
NCT00053625
Mobile Decision Support System for Nurse Management of Neuromodulation Therapy
University of Utah
NCT02474459
Neuroimaging Studies of Depression in Parkinson's Disease
Lee Blonder
NCT00518258
A Study to Compare IPX066 and Carbidopa/Levodopa/Entacapone (CLE) Followed by an Open-Label Safety Study of IPX066
Impax Laboratories
NCT01130493
Cognitive Rehabilitation for PD
VA Office of Research and Development
NCT03335150
An RCT of a Telemedicine Intervention for Hypokinetic Dysarthria in PD
VA Office of Research and Development
NCT04617496
Defining a PD-specific Breath Fingerprint of Underlying Inflammatory and Neurodegenerative Processes
Emory University
NCT02749214
Innovative Measures of Speech and Swallowing Dysfunction in Neurological Disorders
Beth Israel Deaconess Medical Center
NCT02118805
Exercise, Brain Imaging, Cognition, and Gait in Parkinsonism
Oregon Health and Science University
NCT02231073
Valerian to Improve Sleep in Patients With Parkinson's Disease
National Center for Complementary and Integrative Health (NCCIH)
NCT00070928
Executive, Activities of Daily Living, and Cholinergic Functions in Parkinson's Disease
University of Michigan
NCT00737217
Validation of Dyskinesia Rating Scales
Rush University Medical Center
NCT01071395
Imaging Biomarkers of Progression of Mobility Impairment in Parkinson Disease
VA Office of Research and Development
NCT01106976
Early Parkinson's Disease Monotherapy With CVN424
Cerevance Beta
NCT06006247
A Study to Assess the Pharmacokinetics, Safety, and Tolerability of Single and Multiple Doses of Rasagiline
Teva Branded Pharmaceutical Products R&D
NCT01879748
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of BIIB094 in Adults With Parkinson's Disease
Ionis Pharmaceuticals
NCT03976349
Safety and Efficacy of DA-9805 for Parkinson's Disease
Dong-A ST Co.
NCT03189563
Diagnosis of PD and PD Progression Using DWI
University of Alabama at Birmingham
NCT02837172
Ketamine for the Treatment of Depression in Parkinson's Disease
Yale University
NCT04944017
A Study to Assess Safety and Tolerability of Oral AZD3241 in Patients With Parkinson's Disease
AstraZeneca
NCT01603069
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 24 |
| Phase 2 | 31 |
| Phase 3 | 11 |
| Phase 4 | 10 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Parkinson's Disease Trial Landscape
159 indexed Parkinson's Disease studies · 40 recruiting (25%).
Phase mix: 21 late (III/IV) vs 55 early (I/II).
Top sponsor: VA Office of Research and Development (16 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Parkinson's Disease?
PlainTrial tracks 159 US clinical trials for Parkinson's Disease, of which 40 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Parkinson's Disease?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.