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RECRUITING Phase 2

A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight

NCT06143956 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this Phase-2 chronic weight management master protocol (CWMM) is to create a framework to evaluate the safety and efficacy of various investigational interventions for chronic weight management with intervention-specific appendices (ISAs). The CWMM establishes entry criteria for newly enrolled participants across the master and the ISAs. The ISAs may start independently of other ISAs as interventions become available for clinical testing. The results for the CWMM screening record will be reported when all the ISA's complete.

Conditions Studied

Interventions

  • DRUG Placebo
  • DRUG Tirzepatide
  • DRUG LY3305677
  • DRUG LY3841136
  • DRUG LY3549492

Study Locations (20)

Florida

  • Northeast Research Institute (NERI) — Fleming Island
  • Indago Research & Health Center, Inc — Hialeah
  • New Horizon Research Center — Miami
  • Suncoast Clinical Research, Inc. — New Port Richey
  • Charter Research - Winter Park — Orlando
  • Charter Research - Lady Lake — The Villages

Arizona

  • The Institute for Liver Health II dba Arizona Clinical Trials - Mesa — Chandler
  • HOPE Research Institute — Phoenix
  • Headlands Research - Scottsdale — Scottsdale
  • The Institute for Liver Health II dba Arizona Liver Health-Tucson — Tucson

California

  • NorCal Medical Research, Inc — Greenbrae
  • Velocity Clinical Research, Huntington Park — Huntington Park
  • Peninsula Research Associates — Rolling Hills Estates
  • Diablo Clinical Research, Inc. — Walnut Creek

Illinois

  • Great Lakes Clinical Trials - Ravenswood — Chicago
  • Great Lakes Clinical Trials - Ravenswood — Chicago
  • NorthShore University Health System — Skokie

Connecticut

  • Stamford Therapeutics Consortium — Stamford

Hawaii

  • Pacific Diabetes & Endocrine Center — Honolulu

Idaho

  • Medical Research Partners — Ammon

Trial Details

FieldValue
Enrollment Target 1,217 participants
Start Date 2023-11-17
Est. Completion 2026-09
Phase Phase 2

Sponsor

Eli Lilly and Company

704 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06143956

The ClinicalTrials.gov registry entry for NCT06143956 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,217 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Obesity appearing as the primary indexed condition, and to 5 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06143956 reports 20 study locations spanning 7 distinct geographic areas — top geographies include Florida, Arizona, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06143956 about?

NCT06143956 is a clinical study titled "A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight". The purpose of this Phase-2 chronic weight management master protocol (CWMM) is to create a framework to evaluate the safety and efficacy of various investigational interventions for chronic weight management with intervention-specific appendices (ISAs). The CWMM establishes entry criteria for newly...

What is the current status of trial NCT06143956?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 1,217 participants. The study started on 2023-11-17. Estimated completion is 2026-09.

What conditions does trial NCT06143956 study?

This clinical trial studies the following conditions: Obesity, Overweight. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06143956?

The interventions under investigation include: Placebo (DRUG), Tirzepatide (DRUG), LY3305677 (DRUG), LY3841136 (DRUG), LY3549492 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06143956?

This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06143956 being conducted?

This trial has 20 study locations across Arizona, California, Connecticut, Florida, Hawaii. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial