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NCT06972459 · ClinicalTrials.gov registry record · Phase 3
A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and at Least One Weight-Related Comorbidity
A Phase 3 study of Obesity and Overweight, sponsored by Eli Lilly and Company.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 600
- Enrollment target
- 20
- Study locations
NCT06972459 is a Phase 3 study of Obesity and Overweight that is actively recruiting participants, run by Eli Lilly and Company. The registered enrollment target is 600 participants, below the 818-participant average among 1,053 other Obesity trials with a reported enrollment target (27% lower). The trial reports 20 study locations across 7 states.
The verdict
NCT06972459, a Phase 3 study of Obesity and Overweight, is actively recruiting participants, sponsored by Eli Lilly and Company.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 600 participants
- Enrollment target
- 20
- Study locations
Study Summary
The main purpose of this study is to see how orforglipron, compared with placebo, helps reduce body weight in participants with obesity or with overweight and at least one other related health condition (excluding type 2 diabetes). This trial is part of the master protocol study J2A-MC-GZPO (NCT06993792). Participation in the study will last about 18 months.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Orforglipron
Study Locations (20)
Florida
- Accel Research Sites - DeLand Clinical Research Unit - DeLand
- Innovation Medical Research Center - Fort Lauderdale - Fort Lauderdale
- Indago Research & Health Center, Inc - Hialeah
- Encore Medical Research - Hollywood
- West Orange Endocrinology P.A. - Ocoee
- Care Access - Tampa - Tampa
- Conquest Research - Winter Park
Georgia
- Accel Research Sites - NeuroStudies Clinical Research Unit - Decatur
- Care Access - Decatur - Decatur
- Javara - Privia Medical Group Georgia - Savannah - Savannah
- North Georgia Clinical Research - Woodstock
California
- Norcal Endocrinology & Internal Medicine - San Ramon
- Southern California Clinical Research - Santa Ana
- Care Access - Thousand Oaks - Thousand Oaks
Arizona
- Clinical Research Institute of Arizona (CRI) - Sun City West - Sun City West
- Novak Clinical Research - Tucson - North La Cholla Boulevard - Tucson
Maryland
- Endocrine and Metabolic Consultants - Rockville
- Javara - Privia Medical Group - Silver Spring - Silver Spring
Idaho
- Solaris Clinical Research - Meridian
Louisiana
- Care Access - New Iberia - New Iberia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 600 participants |
| Start Date | 2025-05-15 |
| Est. Completion | 2027-08 |
| Phase | Phase 3 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06972459
The ClinicalTrials.gov registry entry for NCT06972459 describes a study currently listed as recruiting, categorized as Phase 3. The registered enrollment target is 600 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 818-participant average among 1,053 other Obesity trials with a reported enrollment target (27% lower). The listed sponsor is Eli Lilly and Company, which has 1,341 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Obesity appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT06972459 reports 20 study locations spanning 7 distinct geographic areas - top geographies include Florida, Georgia, California.
Frequently Asked Questions
What is clinical trial NCT06972459 about?
NCT06972459 is a clinical study titled "A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and at Least One Weight-Related Comorbidity". The main purpose of this study is to see how orforglipron, compared with placebo, helps reduce body weight in participants with obesity or with overweight and at least one other related health condition (excluding type 2 diabetes). This trial is part of the master protocol study J2A-MC-GZPO (NCT0699...
What is the current status of trial NCT06972459?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 600 participants. The study started on 2025-05-15. Estimated completion is 2027-08.
What conditions does trial NCT06972459 study?
This clinical trial studies the following conditions: Obesity, Overweight.
What interventions are being tested in trial NCT06972459?
The interventions under investigation include: Placebo (DRUG), Orforglipron (DRUG).
Who is sponsoring clinical trial NCT06972459?
This trial is sponsored by Eli Lilly and Company, which has 1,341 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06972459 being conducted?
This trial has 20 study locations across Arizona, California, Florida, Georgia, Idaho. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.