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2026 data Public-data reference. official source

Overactive Bladder

Open-data reference.

47 US clinical trials · 21 currently recruiting

Active & Recent Trials

RECRUITING 2,023 participants

Noninvasive Ultrasound Assessment of Detrusor Dysfunction

Mayo Clinic

NCT05652023

RECRUITING NA 300 participants

Pelvic Health Electrically Evoked Recording (PEER) 2 Study

MedtronicNeuro

NCT05200923

RECRUITING Phase 4 270 participants

TReating Incontinence for Underlying Mental and Physical Health

University of California, San Francis

NCT05362292

RECRUITING NA 202 participants

Detrusor Nerve Radiofrequency Ablation for Overactive Bladder in Women

InMode MD

NCT07209397

RECRUITING NA 200 participants

A Real World Study of eCoin for Urgency Urinary Incontinence: Post Approval Evaluation (RECIPE)

Valencia Technologies Corporation

NCT05685433

RECRUITING NA 200 participants

Antibiotic Usage Prior to OnabotulinumtoxinA Injection

Benaroya Research Institute

NCT04754737

RECRUITING NA 193 participants

Percutaneous Nerve Evaluation Trial Time

University of Chicago

NCT06226220

RECRUITING Phase 4 184 participants

Standard Injections Versus Reduced Injections for Intravesical onabotulinumtoxinA Treatment of Overactive Bladder

Walter Reed National Military Medical Center

NCT04020510

RECRUITING NA 166 participants

BTL Emsella Chair Versus Sham for the Treatment of Overactive Bladder

Corewell Health East

NCT04873037

RECRUITING NA 150 participants

Sacral Neuromodulation for Male Overactive Bladder (MOAB)

Axonics

NCT06511141

RECRUITING Phase 4 100 participants

Bladder Botox UTI Antibiotic Prophylaxis

Walter Reed National Military Medical Center

NCT06387329

RECRUITING Phase 2 80 participants

Examining the Effects of Intra-detrusor Botox at Time of HoLEP in Men With Overactive Bladder Symptoms

Northwestern University

NCT05878951

RECRUITING NA 44 participants

Fluoroscopy Radiation Reduction During Sacral Neuromodulation Lead Placement

Loma Linda University

NCT04527445

RECRUITING NA 40 participants

Yoga for Treatment of Overactive Bladder in Pediatric Patients

Duke University

NCT05895045

RECRUITING Phase 4 40 participants

Urinary Microbiome Changes Following Administration of 500 mg of NDS-446 in Women With Dry OAB at 12 Weeks

Loyola University

NCT05557279

RECRUITING NA 38 participants

At-Home Transcutaneous Tibial Nerve Stimulation for Overactive Bladder in Rural Women

Oregon Health and Science University

NCT07178314

RECRUITING NA 30 participants

Home Versus Office Removal of Percutaneous Nerve Evaluation (PNE) Lead

The Cleveland Clinic

NCT05799313

RECRUITING NA 29 participants

Neuromodulating Cortical Regions Involved in Neurogenic Bladder in MS

The Methodist Hospital Research Institute

NCT06072703

RECRUITING NA 20 participants

Add-On ZIDA Sock Therapy for Overactive Bladder

Medical University of South Carolina

NCT07432659

RECRUITING NA 15 participants

Predictive Utility and Mechanisms of Sacral Evoked Responses in Sacral Neuromodulation

University of Michigan

NCT06983470

RECRUITING NA 10 participants

rTMS in Overactive Bladder

The Methodist Hospital Research Institute

NCT06198439

ACTIVE NOT RECRUITING Phase 1 376 participants

Reduced-dose Botox for Urgency Incontinence Among Elder Females

Dartmouth-Hitchcock Medical Center

NCT05512039

COMPLETED Phase 2 1,413 participants

A Study to Evaluate Once Daily Low Dose and High Dose Solabegron or Placebo Given for 12 Weeks to Treat Women With Symptoms of Overactive Bladder: Sudden Urge to Urinate, Frequent Urination Associated With Wetting Episodes (VEL-2001)

Velicept Therapeutics

NCT03594058

COMPLETED Phase 3 557 participants

Study of Botulinum Toxin Type A for the Treatment of Patients With Idiopathic Overactive Bladder With Urinary Incontinence

Allergan

NCT00910845

COMPLETED Phase 4 547 participants

Study of 2 Doses of Solifenacin Succinate in Female Subjects With Overactive Bladder.

Astellas Pharma

NCT01093534

COMPLETED Phase 4 400 participants

Efficacy, Safety, and Tolerability of Darifenacin in Patients Aged > 65 Years With Overactive Bladder

Novartis

NCT00171184

COMPLETED Phase 4 254 participants

OnabotulinumtoxinA (BOTOX®) Treatment for Urinary Incontinence in Patients With Overactive Bladder

Allergan

NCT01945489

COMPLETED Phase 3 249 participants

Anticholinergic vs. Botox Comparison Study

NICHD Pelvic Floor Disorders Network

NCT01166438

COMPLETED Phase 2 204 participants

Combined Behavioral and Drug Treatment of Overactive Bladder in Men

University of Alabama at Birmingham

NCT01175382

COMPLETED NA 154 participants

PRospective Study to Evaluate EffectivenesS With the NURO™ PErcutaneous Tibial Neuromodulation System in Patients With OAB

MedtronicNeuro

NCT02857816

COMPLETED Phase 2 134 participants

Bacterial Genomic Sequencing in Overactive Bladder

Loyola University

NCT01642277

COMPLETED Phase 4 127 participants

Trospium Chloride XR in Obese Female Patients With Overactive Bladder

Allergan

NCT00932022

COMPLETED Phase 4 116 participants

Intradetrusor Botulinum Toxin A for OAB Via 1 Versus 10 Injections: A Randomized Clinical Trial

University of California, Irvine

NCT05308979

COMPLETED Phase 4 100 participants

Overactive Bladder Innovative Therapy Trial (OrBIT)

Uroplasty

NCT00448175

COMPLETED Phase 4 100 participants

Prophylactic Antibiotic Administration for Bladder OnabotulinumtoxinA Injection

The Cleveland Clinic

NCT05719285

COMPLETED 88 participants

Combined Anticholinergic Medication and Sacral Neuromodulation to Treat Refractory Overactive Bladder

University of California, Irvine

NCT01047046

COMPLETED Phase 3 77 participants

Behavioral or Solifenacin Therapy for Urinary Symptoms in Parkinson Disease

VA Office of Research and Development

NCT03149809

COMPLETED Phase 1 77 participants

Evaluation of the Effect of Dried Cranberry Powder in Women With Dry OAB

Weill Medical College of Cornell University

NCT03017170

COMPLETED NA 74 participants

Clinical Trial to Study a Non-invasive Neurostimulation Device on Urgency (Urinary) Incontinence Overactive Bladder (OAB)

Ethicon Endo-Surgery

NCT01125722

COMPLETED 35 participants

A Pilot Study Evaluating the Usability of the Oabi Mobile Application

Massachusetts General Hospital

NCT04534946

COMPLETED Phase 1 25 participants

Botulin-A Toxin Instillations and Overactive Bladder

Mayo Clinic

NCT00583219

COMPLETED Phase 1 24 participants

A Study To Test The Interaction of Two Medications for Treatment of Overactive Bladder

GlaxoSmithKline

NCT00501267

COMPLETED 18 participants

Pilot Study: Is Overactive Bladder Caused by Subacute Urinary Tract Infections?

University of Rochester

NCT00714792

COMPLETED Phase 1 18 participants

A Two-Part Study to Determine: Best Medication Formulation and Food Effect

GlaxoSmithKline

NCT00427596

COMPLETED Phase 4 12 participants

Higher Neural Changes Following Anticholinergic, Beta 3 Agonist, or Placebo in Patients With Overactive Bladder

Baylor Research Institute

NCT03817931

COMPLETED NA 10 participants

Clinical Feasibility Study, Implantable Tibial Nerve Stimulator (ITNS)

Nine Continents Medical

NCT04115228

COMPLETED Phase 2

Two Phase Extension Trial of SP668 to Investigate the Safety and Tolerability of Sustained Release Fesoterodine in Subjects With Overactive Bladder: a Double-Blind Phase Followed by an Open-Label Extension Phase

Pfizer

NCT00220389

Phase Distribution

PhaseTrial count
Early Phase 1 5
Phase 2 5
Phase 3 3
Phase 4 12

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Overactive Bladder Trial Landscape

ClinicalTrials.gov lists 47 US studies indexed under Overactive Bladder, and 21 of those are currently open to recruitment — roughly 45% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Overactive Bladder shows 15 late-stage studies (Phase 3 and Phase 4 combined) alongside 10 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Overactive Bladder is led by Allergan with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 47 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Overactive Bladder?

PlainTrial tracks 47 US clinical trials for Overactive Bladder, of which 21 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Overactive Bladder?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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