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ClinicalTrials.gov 26 recruiting now official registry

Gastric Adenocarcinoma clinical trials

Every US clinical trial registered for Gastric Adenocarcinoma — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

48 US clinical trials · 26 currently recruiting

The research picture

Gastric Adenocarcinoma has 48 registered US clinical trials, 26 of them open to new participants right now — about 54% of the total.

26
recruiting participants now
54%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
5
top sponsor: M.D. Anderson Cancer Center

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 3,200 participants

A Study Collecting Health Information to Understand and Prevent Gastric Cancer

Memorial Sloan Kettering Cancer Center

NCT06370143

RECRUITING 2,020 participants

ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

Guardant Health

NCT05059444

RECRUITING Phase 1 398 participants

A Study of ASP2138 Given by Itself or Given With Other Cancer Treatments in Adults With Stomach Cancer, Gastroesophageal Junction Cancer, or Pancreatic Cancer

Astellas Pharma Global Development

NCT05365581

RECRUITING Phase 1 260 participants

A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors

IDEAYA Biosciences

NCT07277413

RECRUITING Phase 1 155 participants

First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors

Plexium

NCT07284186

RECRUITING Phase 1 150 participants

A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors

Normunity AccelCo

NCT07182149

RECRUITING Phase 2 148 participants

Testing the Addition of Paclitaxel Administered Into the Abdominal Cavity Combined With Chemotherapy for Patients With Gastric Cancer Spread to the Abdominal Cavity

ECOG-ACRIN Cancer Research Group

NCT07001748

RECRUITING Phase 2 146 participants

A Study of TRK-950 When Used in Combination With Ramucirumab and Paclitaxel in Patients With Gastric Cancer

Toray Industries

NCT06038578

RECRUITING Phase 1 144 participants

AVA6103 in Subjects With Locally Advanced or Metastatic Selected Solid Tumors

Avacta Life Sciences

NCT07454642

RECRUITING Phase 1 120 participants

Evaluate the Safety, Tolerability, Pharmacokinetics and Efficacy of BL-M05D1 in Subjects With Solid Tumors

SystImmune

NCT07021066

RECRUITING Phase 1 101 participants

A Study of KK2269 in Adult Participants With Solid Tumors

Kyowa Kirin Co.

NCT06266299

RECRUITING Phase 2 100 participants

Chemotherapy With or Without Radiation or Surgery in Treating Participants With Oligometastatic Esophageal or Gastric Cancer

M.D. Anderson Cancer Center

NCT03161522

RECRUITING Phase 1 100 participants

A Study to Investigate APL-5125 in Adults With Advanced Solid Tumors

Apollo Therapeutics

NCT06399757

RECRUITING Phase 2 72 participants

Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies

Dan Zandberg

NCT04114136

RECRUITING Phase 2 54 participants

Trial Comparing Standard of Care Therapy With and Without Sequential Cytoreductive Intervention for Patients With Metastatic Foregut Adenocarcinoma and Undetectable Circulating Tumor-Deoxyribose Nucleic Acid (ctDNA) Levels

Yale University

NCT07282912

RECRUITING Phase 2 52 participants

Oxaliplatin and Liposomal Irinotecan (Plus Trastuzumab for HER2-positive Disease) in Advanced Esophageal and Gastric Adenocarcinoma

University of Wisconsin, Madison

NCT04150640

RECRUITING Phase 2 49 participants

A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric Cancer

Memorial Sloan Kettering Cancer Center

NCT06123338

RECRUITING Phase 2 40 participants

Robotic Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy for Treatment of Gastric Cancer With Limited Peritoneal Metastasis, ROBO-CHIP Study

Mayo Clinic

NCT05753306

RECRUITING Phase 4 36 participants

Genetic Analysis-Guided Irinotecan Hydrochloride Dosing of mFOLFIRINOX in Treating Patients With Locally Advanced Gastroesophageal or Stomach Cancer

University of Chicago

NCT02366819

RECRUITING Phase 2 30 participants

A Phase II Study of Perioperative Paclitaxel in Patients With Gastric Adenocarcinoma and Carcinomatosis or Positive Cytology

M.D. Anderson Cancer Center

NCT05977998

RECRUITING Phase 2 30 participants

PHASE II EVALUATION OF CYTOREDUCTION SURGERY AND HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY (CRS/HIPEC) IN GASTRIC CANCER

Banner Health

NCT07178808

RECRUITING Phase 2 27 participants

Study of Suratadenoturev (OBP-301) in Combination With Pembrolizumab in Esophagogastric Adenocarcinoma

Weill Medical College of Cornell University

NCT06340711

RECRUITING Phase 3 20 participants

Evaluating Novel Therapies in ctDNA Positive GI Cancers

Georgetown University

NCT05482516

RECRUITING Phase 1 18 participants

Intra-tumoral (IT) Injection of vvDD-hIL2-2-RG-1 for Metastatic Gastrointestinal and Peritoneal Tumors

Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

NCT07001592

RECRUITING Phase 1 15 participants

Aldesleukin With Nivolumab and Standard Chemotherapy for Treatment of Gastric Cancer With Peritoneal Metastasis

Mayo Clinic

NCT05802056

RECRUITING Phase 2 10 participants

Tadalafil Effect + Chemotherapy in Resectable Gastric/GEJ Cancer

University of Arizona

NCT05709574

ACTIVE NOT RECRUITING Phase 1 1,410 participants

Phase I-II, FIH, TROP2 ADC, Advanced Unresectable/Metastatic Solid Tumors, Refractory to Standard Therapies (KL264-01)

Klus Pharma

NCT04152499

ACTIVE NOT RECRUITING Phase 2 240 participants

Testing Immunotherapy (Atezolizumab) With or Without Chemotherapy in Locoregional MSI-H/dMMR Gastric and Gastroesophageal Junction (GEJ) Cancer

National Cancer Institute (NCI)

NCT05836584

ACTIVE NOT RECRUITING Phase 2 127 participants

A Study of Evorpacept (ALX148) in Patients With Advanced HER2+ Gastric Cancer (ASPEN-06)

ALX Oncology

NCT05002127

ACTIVE NOT RECRUITING Phase 1 64 participants

TAS102 in Combination With NAL-IRI in Advanced GI Cancers

Emory University

NCT03368963

ACTIVE NOT RECRUITING 52 participants

Early Recovery After Surgery Protocol in Improving Quality of Life in Participants With Stage 0-IIIC Gastric Cancer Undergoing Surgery

City of Hope Medical Center

NCT03997162

ACTIVE NOT RECRUITING Phase 2 48 participants

A Vaccine (Ad5.F35-hGCC-PADRE) for the Treatment of Gastrointestinal Adenocarcinoma

Thomas Jefferson University

NCT04111172

ACTIVE NOT RECRUITING Phase 2 40 participants

Tucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy or Pembrolizumab-containing Combinations for HER2+ Gastrointestinal Cancers

Seagen, a wholly owned subsidiary of Pfizer

NCT04430738

ACTIVE NOT RECRUITING Phase 2 40 participants

Pembrolizumab, Capecitabine, and Radiation Therapy in Treating Patients With Mismatch-Repair Deficient and Epstein-Barr Virus Positive Gastric Cancer

Rutgers, The State University of New Jersey

NCT03257163

ACTIVE NOT RECRUITING Phase 2 34 participants

Ph II Study of Cabozantinib With Pembrolizumab in Metastatic Gastric and Gastroesophageal Adenocarcinoma

University of California, Irvine

NCT04164979

ACTIVE NOT RECRUITING Phase 2 32 participants

Nivolumab, Ipilimumab and Chemoradiation in Treating Patients With Resectable Gastric Cancer

M.D. Anderson Cancer Center

NCT03776487

ACTIVE NOT RECRUITING Phase 1 25 participants

Short-Course Chemoradiotherapy Followed by Chemotherapy for the Treatment of Resectable Gastric Adenocarcinoma

M.D. Anderson Cancer Center

NCT04523818

COMPLETED 809 participants

Stomach Cancer Exosome-based Detection

City of Hope Medical Center

NCT06342427

COMPLETED 397 participants

Assessment of What Patients and Healthcare Providers Value

M.D. Anderson Cancer Center

NCT04483349

COMPLETED Phase 2 195 participants

Phase II Randomized Trial of Bethesda Protocol Compared to Cambridge Method for Detection of Early Stage Gastric Cancer in CDH1 Mutation Carriers

National Cancer Institute (NCI)

NCT04535414

COMPLETED Phase 2 164 participants

A Phase 2 Study of Ramucirumab (LY3009806) in Participants With Gastric or Gastroesophageal Junction (GEJ) Cancer

Eli Lilly and Company

NCT02443883

COMPLETED Phase 1 151 participants

A Study of DKN-01 in Combination With Paclitaxel or Pembrolizumab

Leap Therapeutics

NCT02013154

COMPLETED Phase 1 64 participants

Oral STAT3 Inhibitor, TTI-101, in Patients with Advanced Cancers

Tvardi Therapeutics, Incorporated

NCT03195699

COMPLETED Phase 2 55 participants

Irinotecan and Cisplatin in Treating Patients Who Are Undergoing Surgery For Locally Advanced Cancer of the Stomach or Gastroesophageal Junction

National Cancer Institute (NCI)

NCT00062374

COMPLETED Phase 2 35 participants

Pralatrexate and Oxaliplatin in Treating Patients With Unresectable or Metastatic Esophageal, Stomach, or Gastroesophageal Junction Cancer

Roswell Park Cancer Institute

NCT01178944

COMPLETED Phase 2 25 participants

Study of 5-Fluorouracil and Leucovorin and Intra-abdominal Floxuridine Chemoradiation in Patients With Fully Resected Locally Advanced Gastric Adenocarcinoma

University of Southern California

NCT00183911

COMPLETED Phase 2 17 participants

Tucatinib, Trastuzumab, Ramucirumab, and Paclitaxel Versus Paclitaxel and Ramucirumab in Previously Treated HER2+ Gastroesophageal Cancer

Seagen

NCT04499924

COMPLETED Phase 2 12 participants

Intraperitoneal and Intravenous Paclitaxel Chemotherapy With Oral Capecitabine for Gastric Adenocarcinoma With Peritoneal Carcinomatosis

National Cancer Institute (NCI)

NCT04034251

Phase Distribution

PhaseTrial count
Phase 1 15
Phase 2 26
Phase 3 1
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Gastric Adenocarcinoma Trial Landscape

ClinicalTrials.gov lists 48 US studies indexed under Gastric Adenocarcinoma, and 26 of those are currently open to recruitment — roughly 54% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Gastric Adenocarcinoma shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 41 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Gastric Adenocarcinoma is led by M.D. Anderson Cancer Center with 5 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 48 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Gastric Adenocarcinoma?

PlainTrial tracks 48 US clinical trials for Gastric Adenocarcinoma, of which 26 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Gastric Adenocarcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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