The Methodist Hospital Research Institute

203 total trials 186 currently recruiting 8 completed

Trial Pipeline

RECRUITING Phase 1

Anterior Cruciate Ligament (ACL) Reconstruction With Autologous Fat Pad Derived Mesenchymal Stem Cells

NCT06798623

RECRUITING Phase 2

Trial to Study Anti- HCMV Therapy in Breast Cancer Patients With Progressive Intracranial Metastases and CMV Infection

NCT07383649

RECRUITING Phase 2

Trial of 5-Fluorouracil (5FU)-Based Therapy in Combination With Fruquintinib in Patients With Locally Advanced Unresectable or Metastatic Colorectal Cancer

NCT07042685

RECRUITING NA

Bone Stimulator for Spondylolysis

NCT06666608

RECRUITING NA

VoiceLove Digital Therapy for Delirium in the ICU

NCT07218484

RECRUITING Phase 2

Comprehensive Multimodal Prehabilitation Alone or With Neoadjuvant Therapy Before Major Cancer Surgery

NCT07050771

RECRUITING Phase 1

Neoadjuvant High Dose Rate Brachytherapy Prior to Radical Prostatectomy in Patients With Prostate Cancer

NCT07182279

RECRUITING Phase 1

Intraosseous (IO) Cefazolin and Vancomycin in Primary Total Knee Arthroplasty (TKA)

NCT06640491

RECRUITING Phase 2

5-Fluorouracil/Leucovorin (5FU/LV) in Combination With Regorafenib in Patients With Metastatic Colorectal Cancer

NCT06887218

RECRUITING NA

Non-invasive VNS in Stroke Recovery

NCT06761404

RECRUITING NA

Prehabilitation for Kidney Transplant Candidates

NCT06886256

RECRUITING NA

Blood Flow Restriction (BFR) Training on the Ulnar Collateral Ligament (UCL)

NCT06664827

RECRUITING NA

Personalized Transcranial Direct Current Stimulation in Stroke Recovery

NCT06286800

RECRUITING NA

Home Tele Rehabilitation Therapy for Vascular Dementia

NCT06289569

RECRUITING Phase 1

Phase I Trial of 5-Fluorouracil (5FU) -Based Therapy in Combination With Hydroxytyrosol (HT) in Patients With Advanced or Metastatic Colorectal Cancer

NCT06833866

RECRUITING Phase 4

Intraosseous vs. Intravenous Vancomycin Administration in Total Ankle Arthroplasty

NCT06384651

RECRUITING Phase 1

Thymalfasin (Thymosin Alpha 1; Ta1) as an Enhancer of Vaccine Response Among Older Adults Receiving Booster Doses of COVID-19 Vaccine

NCT06821100

RECRUITING Phase 1

Honokiol in Early-Stage Resectable Non-Small Cell Lung Cancer

NCT06566443

RECRUITING Phase 4

Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction

NCT06511232

RECRUITING NA

Augmenting Rehabilitation Outcomes and Functional Neuroplasticity Using Epidural Stimulation of Cervical Spinal Cord

NCT06225245

RECRUITING Phase 1

ATRA and Carfilzomib in Plasma Cell Myeloma Patients

NCT06536413

RECRUITING

MRI Guided Management of Occlusive Peripheral Arterial Disease

NCT06782100

RECRUITING Phase 3

Spiritual Care or Psychotherapy Versus Palliative Care Alone in Patients With Non-Curative Malignancies

NCT07290491

RECRUITING Phase 1

CBD for Pain Following Orthopedic Shoulder Surgery

NCT06381791

RECRUITING Phase 1

IL-2 Plus Abatacept in FTD

NCT06395038

RECRUITING NA

Endoscopic Sleeve Gastroplasty (ESG) for the Treatment of Obesity

NCT06339320

RECRUITING NA

Protein Supplementation After ACL Surgery

NCT06311058

RECRUITING NA

rTMS in Overactive Bladder

NCT06198439

RECRUITING NA

Harnessing Neuroplasticity of Postural Sensorimotor Networks Using Non-Invasive Spinal Neuromodulation to Maximize Functional Recovery After Spinal Cord Injury

NCT06213012

RECRUITING NA

Neuromodulating Cortical Regions Involved in Neurogenic Bladder in MS

NCT06072703

RECRUITING Phase 2

Venous Ethanol for Ventricular Tachycardia

NCT05511246

RECRUITING Phase 2

Systemic and Central Inflammation in AD

NCT06384378

RECRUITING Phase 4

Atezolizumab and Bevacizumab Pre-Liver Transplantation for Patients With Hepatocellular Carcinoma Beyond Milan Criteria

NCT05185505

RECRUITING Phase 2

Alpelisib/iNOS Inhibitor/Nab-paclitaxel in Patients With HER2 Negative Metaplastic Breast Cancer (MpBC)

NCT05660083

RECRUITING Phase 2

Phase II Clinical Trial of Interleukin-2 in AD

NCT06096090

RECRUITING NA

LSTR in Chevron Osteotomy

NCT06486753

RECRUITING Phase 2

Fulvestrant+Abemaciclib With Run-In of Fulvestrant in Er-Positive, Her2-Negative Metastatic Breast Cancer

NCT05305924

RECRUITING

Dynamics of Colonization and Infection by Multidrug-Resistant Pathogens in Immunocompromised and Critically Ill Patients

NCT06258551

RECRUITING NA

Effect of BFR Rehab After Achilles Tendon Rupture

NCT06254794

RECRUITING NA

Limb Occlusion Pressure Tourniquets to Decrease Pain After Surgery

NCT04390425

RECRUITING Phase 1

HSV-tk and XRT and Chemotherapy for Newly Diagnosed GBM

NCT03603405

RECRUITING Phase 1

HSV-tk + Valacyclovir Therapy in Combination With Brachytherapy for Recurrent Prostate Cancer

NCT01913106

ACTIVE NOT RECRUITING Phase 4

IO Vancomycin in TSA

NCT05831774

ACTIVE NOT RECRUITING Phase 2

Neoadjuvant Sasanlimab With Radiation as an in Situ Vaccine for Cisplatin-ineligible Muscle Invasive Bladder Cancer

NCT05241340

ACTIVE NOT RECRUITING Phase 1

Study in ALS With Abatacept & IL-2

NCT06307301

ACTIVE NOT RECRUITING Phase 1

Neoadjuvant Atezolizumab in Cutaneous Melanoma

NCT04020809

ACTIVE NOT RECRUITING Phase 2

Durvalumab with Trastuzumab and Pertuzumab in HER2-Enriched Breast Cancer

NCT03820141

ACTIVE NOT RECRUITING NA

ORIF Distal Radius Blood Flow Restriction Therapy

NCT06136286

ACTIVE NOT RECRUITING Phase 1

Olaparib in Combination With Vorinostat in Patients With Relapsed/Refractory and/or Metastatic Breast Cancer

NCT03742245

ACTIVE NOT RECRUITING Phase 1

Phase Ib of L-NMMA and Pembrolizumab

NCT03236935

ACTIVE NOT RECRUITING Phase 2

Mesenchymal Stromal Cells in Living Donor Kidney Transplantation

NCT03478215

COMPLETED NA

Feasibility and Acceptability of ReCognitionVR-based Cognitive Stimulation in Surgical Patients

NCT06232317

COMPLETED NA

Neuromuscular Training in Female Youth Soccer

NCT06136299

COMPLETED NA

Opioid Use After Thyroid and Parathyroid Surgeries

NCT04955444

COMPLETED NA

Explore Transplant at Home: Improving Low-Income ESRD Patients' Transplant Knowledge

NCT02268682

COMPLETED

Central Nervous System Changes Following OnabotulinumtoxinA Injection in the Bladder

NCT03033355

COMPLETED Phase 4

Ciprofloxacin for Prevention of BK Infection

NCT01789203

COMPLETED Phase 2

A Trial of Esophageal and Gastric Stenting for Leak or Perforation

NCT01107249

COMPLETED Phase 2

Safety and Toxicity Study of Sorafenib in Patients With Kidney Cancer

NCT00445042

What the Pipeline for The Methodist Hospital Research Institute Shows

According to the ClinicalTrials.gov registry, The Methodist Hospital Research Institute is linked to 203 US clinical trials across every stage of research activity. Of those, 186 studies are currently recruiting — about 92% of the sponsor's indexed portfolio — and 8 are already marked complete, representing roughly 4% of the total. Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

The phase mix for The Methodist Hospital Research Institute reports 33 late-stage studies (Phase 3 and Phase 4 combined) and 57 earlier-phase studies (Phase 1 and Phase 2). A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work — safety, dosing, and early signal detection — and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

The top therapeutic focus area indexed for The Methodist Hospital Research Institute is HER2-negative Breast Cancer with 2 linked trials, and 9 other condition areas appear in the top list above. That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice — verify current details directly with ClinicalTrials.gov before relying on any figure here.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial