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NCT05512039 · ClinicalTrials.gov registry record · Phase 1
Reduced-dose Botox for Urgency Incontinence Among Elder Females
A Phase 1 study of Overactive Bladder and Urgency Urinary Incontinence, sponsored by Dartmouth-Hitchcock Medical Center.
- Active
- Registry status
- Phase 1
- Development phase
- 376
- Enrollment target
- 7
- Study locations
NCT05512039: Active Phase 1 study of Overactive Bladder and Urgency Urinary Incontinence, sponsored by Dartmouth-Hitchcock Medical Center.
NCT05512039 is a Phase 1 study of Overactive Bladder and Urgency Urinary Incontinence that is active but no longer recruiting, run by Dartmouth-Hitchcock Medical Center. The registered enrollment target is 376 participants, above the 199-participant average among 46 other Overactive Bladder trials with a reported enrollment target (89% higher). The trial reports 7 study locations across 7 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05512039, a Phase 1 study of Overactive Bladder and Urgency Urinary Incontinence, is active but no longer recruiting, sponsored by Dartmouth-Hitchcock Medical Center.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 376 participants
- Enrollment target
- 7
- Study locations
Study Summary
The purpose of this study is to study the treatment of urgency urinary incontinence (UUI), specifically among women 70 years and older, by comparing reduced versus standard dose of onabotulinumtoxinA (BTX; trade name BOTOX(c)) injection in the bladder.
Primary Outcome
The Overactive bladder questionnaire (OABq-SF), is a validated and reliable patient-centered quality of life questionnaire. The OABq-SF is based on a continuous sore of 0-100, with higher score translating to greater bother.
Conditions Studied
Interventions
- DRUG Botox 50 Unit Injection
- DRUG Botox 100 Unit Injection
Study Locations (7)
Alabama
- University of Alabama - Birmingham - Birmingham
California
- Kaiser Permanente Medical Group - San Diego
Nebraska
- University of Nebraska Medical Center - Omaha
New Hampshire
- Dartmouth-Hitchcock Medical Center - Lebanon
Oregon
- Oregon Health & Science University - Portland
Pennsylvania
- University of Pittsburgh Medical Center - Pittsburgh
Texas
- University of Texas Southwestern Medical Center - Dallas
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 376 participants |
| Start Date | 2023-05-12 |
| Est. Completion | 2027-01-01 |
| Phase | Phase 1 |
What the registry record for NCT05512039 still lists
NCT05512039 is an interventional study that assigns participants to a tested intervention. The registered 376 participants enrollment target is mid-sized for trials with a published cap, above the 199-participant average among 46 other Overactive Bladder trials with a reported enrollment target (89% higher).
The record links to 3 conditions, with Overactive Bladder appearing as the primary indexed condition, and to 2 interventions - of which Botox 50 Unit Injection is the first listed.
NCT05512039 lists 7 locations in 7 states (Alabama, California, Nebraska).
Frequently Asked Questions
What is clinical trial NCT05512039 about?
NCT05512039 is a clinical study titled "Reduced-dose Botox for Urgency Incontinence Among Elder Females". The purpose of this study is to study the treatment of urgency urinary incontinence (UUI), specifically among women 70 years and older, by comparing reduced versus standard dose of onabotulinumtoxinA (BTX; trade name BOTOX(c)) injection in the bladder.
What is the current status of trial NCT05512039?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 376 participants. The study started on 2023-05-12. Estimated completion is 2027-01-01.
What conditions does trial NCT05512039 study?
This clinical trial studies the following conditions: Overactive Bladder, Urgency Urinary Incontinence, Urinary Incontinence in Old Age.
What interventions are being tested in trial NCT05512039?
The interventions under investigation include: Botox 50 Unit Injection (DRUG), Botox 100 Unit Injection (DRUG).
Who is sponsoring clinical trial NCT05512039?
This trial is sponsored by Dartmouth-Hitchcock Medical Center, which has 427 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05512039 being conducted?
This trial has 7 study locations across Alabama, California, Nebraska, New Hampshire, Oregon. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Overactive Bladder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05512039's enrollment target sits among peer trials
376 6th of 46 higher than 41 of 46 other Overactive Bladder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Overactive Bladder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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