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2026 data Public-data reference. official source

Brain Cancer

Open-data reference.

48 US clinical trials · 20 currently recruiting

Active & Recent Trials

RECRUITING 8,000 participants

The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study

UMC Utrecht

NCT04075305

RECRUITING 7,000 participants

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

Adela

NCT05366881

RECRUITING 3,500 participants

Wearable Devices and Biomarkers Project (Healthiomics)

CureScience

NCT05106725

RECRUITING Phase 3 432 participants

Repeated Superselective Intraarterial Cerebral Infusion (SIACI) of Bevacizumab With Temozolomide and Radiation Compared to Temozolomide and Radiation Alone in Newly Diagnosed GBM

Northwell Health

NCT05271240

RECRUITING Phase 2 190 participants

Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma

Baptist Health South Florida

NCT06991101

RECRUITING Phase 2 162 participants

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

Black Diamond Therapeutics

NCT07326566

RECRUITING NA 135 participants

Magnetic Resonance (MR) Imaging to Determine High Risk Areas in Patients With Malignant Gliomas and to Design Potential Radiation Plans and to Examine Metabolite Changes in Gliomas and Other Solid Tumors

Memorial Sloan Kettering Cancer Center

NCT00870129

RECRUITING NA 125 participants

HOBSCOTCH-CA (HOme-Based Self-management and COgnitive Training CHanges Lives in Brain CAncer)

Dartmouth-Hitchcock Medical Center

NCT06930846

RECRUITING NA 80 participants

Observational Study of Responses to Treatments in Advanced Central Nervous System (CNS) Tumors

National Cancer Institute (NCI)

NCT07374692

RECRUITING Phase 1 67 participants

Oral Capecitabine and Temozolomide (CAPTEM) for Newly Diagnosed GBM

Northwell Health

NCT03213002

RECRUITING Phase 1 46 participants

18F-Fluciclovine PET Amino Acid Evaluation of Brain Metastasis Treated With Stereotactic Radiosurgery

Baptist Health South Florida

NCT06048094

RECRUITING Phase 2 37 participants

Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA

Northwell Health

NCT02800486

RECRUITING Phase 1 33 participants

Super-selective Intra-arterial Repeated Infusion of Cetuximab for the Treatment of Newly Diagnosed Glioblastoma

Northwell Health

NCT02861898

RECRUITING NA 32 participants

Surgical Tissue Flap to Bypass the Blood Brain Barrier in Glioblastoma

Northwell Health

NCT05954858

RECRUITING Phase 2 30 participants

Trastuzumab Deruxtecan (T-DXd) for People With Brain Cancer

Memorial Sloan Kettering Cancer Center

NCT06058988

RECRUITING Phase 2 30 participants

Diagnostic Performance of Fluorescein as an Intraoperative Brain Tumor Biomarker

David W. Roberts

NCT02691923

RECRUITING Phase 1 20 participants

Assess Use of 18F-Fluciclovine for Patients With Large Brain Metastases Treated With Staged Stereotactic Radiosurgery

Baptist Health South Florida

NCT04689048

RECRUITING Phase 2 20 participants

Characterization of 18F-Fluciclovine PET Amino Acid Radiotracer in Resected Brain Metastasis

Baptist Health South Florida

NCT05554302

RECRUITING Phase 1 18 participants

Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.

Henry Ford Health System

NCT05686798

RECRUITING NA 10 participants

Omental Tissue Autograft in Human Recurrent Glioblastoma Multiforme (rGBM)

Northwell Health

NCT05979064

ACTIVE NOT RECRUITING 1,000 participants

Tempus Priority Study: A Pan-tumor Observational Study

Tempus AI

NCT05179824

ACTIVE NOT RECRUITING 309 participants

Coping With Glioblastoma: A Study of Communication Between Physicians, Patients, and Caregivers

Memorial Sloan Kettering Cancer Center

NCT02375841

ACTIVE NOT RECRUITING Phase 2 134 participants

Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases

Brigham and Women's Hospital

NCT04899908

ACTIVE NOT RECRUITING Phase 1 125 participants

A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors

Sapience Therapeutics

NCT04478279

ACTIVE NOT RECRUITING 60 participants

A Study to Measure the Effect of Brain Stimulation on Hand Strength and Function in Patients With Brain Tumors

Medical College of Wisconsin

NCT05023434

ACTIVE NOT RECRUITING 60 participants

Observational Trial of the Impact of Radiation Dose in Children With Brain and Skull Base Tumors.

Baptist Health South Florida

NCT03972514

ACTIVE NOT RECRUITING Phase 1 60 participants

A Pilot Surgical Trial To Evaluate Early Immunologic Pharmacodynamic Parameters For The PD-1 Checkpoint Inhibitor, Pembrolizumab (MK-3475), In Patients With Surgically Accessible Recurrent/Progressive Glioblastoma

Dana-Farber Cancer Institute

NCT02852655

ACTIVE NOT RECRUITING Phase 1 17 participants

A First in Human Study Using 89Zr-cRGDY Ultrasmall Silica Particle Tracers for Malignant Brain Tumors

Memorial Sloan Kettering Cancer Center

NCT03465618

ACTIVE NOT RECRUITING NA 12 participants

Surgical Tissue Flap to Bypass the Blood Brain Barrier in GBM

Northwell Health

NCT03630289

ACTIVE NOT RECRUITING NA 6 participants

Pilot Study of Optune (NovoTTF-100A) for Recurrent Atypical and Anaplastic Meningioma

Memorial Sloan Kettering Cancer Center

NCT01892397

COMPLETED 1,214 participants

Natural History of and Specimen Banking for People With Tumors of the Central Nervous System

National Cancer Institute (NCI)

NCT02851706

COMPLETED Early Phase 1 200 participants

Determine if Apparent Diffusion Coefficient (ADC) Values Can Differentiate Tumors From Normal Tissue

University of Michigan

NCT00723463

COMPLETED Phase 3 152 participants

Randomized Trial Comparing Radiosurgery With vs Without Whole Brain Radiotherapy

M.D. Anderson Cancer Center

NCT00548756

COMPLETED Phase 2 83 participants

Standard Dose Bevacizumab Versus Low Dose Bevacizumab Plus Lomustine (CCNU) for Recurrent Glioblastoma Multiforme (GBM)

M.D. Anderson Cancer Center

NCT01067469

COMPLETED Phase 2 75 participants

6-TG, Capecitabine and Celecoxib Plus TMZ or CCNU for Anaplastic Glioma Patients

M.D. Anderson Cancer Center

NCT00504660

COMPLETED NA 52 participants

Imaging Study on Halcyon 4.0 System for Patients Receiving Radiation Therapy

Washington University School of Medicine

NCT05427214

COMPLETED Phase 1 50 participants

Convection-Enhanced Delivery of 124I-Omburtamab for Patients With Non-Progressive Diffuse Pontine Gliomas Previously Treated With External Beam Radiation Therapy

Y-mAbs Therapeutics

NCT01502917

COMPLETED 50 participants

(1)H-Nuclear Magnetic Resonance Spectroscopic Imaging of the Brain in Patients Who Receive Neurotoxic Therapy

National Cancer Institute (NCI)

NCT00001807

COMPLETED Phase 2 44 participants

Tarceva With Whole Brain Radiation Therapy - Brain Mets From Non-Small Cell Lung Cancer

M.D. Anderson Cancer Center

NCT00871923

COMPLETED 40 participants

Feasibility of a Consumer Based Accelerometer in Monitoring Outpatient Physical Activity: A Study in Patients With Cancer and Amyotrophic Lateral Sclerosis

Duke University

NCT02457715

COMPLETED NA 30 participants

Imaging Brain Tumors With FACBC and Methionine

Memorial Sloan Kettering Cancer Center

NCT00597246

COMPLETED Phase 1 24 participants

IDH1 Peptide Vaccine for Recurrent Grade II Glioma

Katy Peters, MD, PhD

NCT02193347

COMPLETED Phase 1 22 participants

EGFR Inhibition Using Weekly Erlotinib for Recurrent Malignant Gliomas

Andrew B Lassman, MD

NCT01257594

COMPLETED Phase 1 17 participants

Phase I Vorinostat Concurrent With Stereotactic Radiosurgery (SRS) in Brain Metastases From Non-Small Cell Lung Cancer

Stanford University

NCT00946673

COMPLETED Phase 1 12 participants

Phase I Trial of Arsenic Trioxide and Stereotactic Radiotherapy for Recurrent Malignant Glioma

Stanford University

NCT00185861

COMPLETED Phase 1 11 participants

Phase I, Open Label, Single Center Safety Study of [F-18]FLT

Siemens Molecular Imaging

NCT00553748

COMPLETED Phase 1 10 participants

Monteris AutoLITT™ FIM Safety Trial for Recurrent/Progressive Brain Tumors

Monteris Medical

NCT00747253

COMPLETED Early Phase 1 5 participants

PET and MRI Imaging of Brain Tumors Using [18F]PARPi

Memorial Sloan Kettering Cancer Center

NCT04173104

Phase Distribution

PhaseTrial count
Early Phase 1 17
Phase 2 10
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Brain Cancer Trial Landscape

ClinicalTrials.gov lists 48 US studies indexed under Brain Cancer, and 20 of those are currently open to recruitment — roughly 42% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Brain Cancer shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 27 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Brain Cancer is led by Northwell Health with 7 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 48 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Brain Cancer?

PlainTrial tracks 48 US clinical trials for Brain Cancer, of which 20 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Brain Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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