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2026 data Public-data reference. official source

Acute Respiratory Distress Syndrome

Open-data reference.

32 US clinical trials · 14 currently recruiting

Active & Recent Trials

RECRUITING 1,260 participants

Dead Space and Inhaled Nitric Oxide in Pediatric Acute Respiratory Distress Syndrome

Children's Hospital Los Angeles

NCT06690801

RECRUITING Phase 3 1,100 participants

Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome

Beth Israel Deaconess Medical Center

NCT06066502

RECRUITING Phase 3 970 participants

Extracellular Vesicle Treatment for Acute Respiratory Distress Syndrome (ARDS) (EXTINGUISH ARDS)

Direct Biologics

NCT05354141

RECRUITING Phase 2 600 participants

JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS (Master Record)

PPD Development

NCT06703073

RECRUITING Phase 2 600 participants

Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)

BioAegis Therapeutics

NCT05947955

RECRUITING 550 participants

ARDS in Children and ECMO Initiation Strategies Impact on Neurodevelopment (ASCEND)

University of Michigan

NCT05388708

RECRUITING Phase 2 200 participants

JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort C: Bevacizumab

PPD Development

NCT06701656

RECRUITING Phase 2 200 participants

JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort A: Vilobelimab

PPD Development

NCT06701682

RECRUITING Phase 2 200 participants

JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort B: Paridiprubart

PPD Development

NCT06701669

RECRUITING NA 178 participants

The Effects of Music Therapy on Adult Patients Requiring Mechanical Ventilation in the ICU

Icahn School of Medicine at Mount Sinai

NCT03642002

RECRUITING Phase 2 120 participants

Phase 2a Multiple Ascending Dose Study in Hospitalized Patients With Pneumonia.

Vasomune Therapeutics

NCT05123755

RECRUITING Phase 2 56 participants

Anti-CD14 Treatment With IC14 in Hospitalized ARDS Patients

Implicit Bioscience

NCT06513949

RECRUITING NA 56 participants

Macrophage Programing in Acute Lung Injury: MiniBAL

William Janssen, MD

NCT05767671

RECRUITING NA 40 participants

The ARISE Study - Use of Vertical Positioning

University of Alabama at Birmingham

NCT07025421

ACTIVE NOT RECRUITING 4,000 participants

Molecular Epidemiology of Acute Respiratory Distress Syndrome (ARDS)

Massachusetts General Hospital

NCT00006496

ACTIVE NOT RECRUITING Phase 2 32 participants

Safety and Efficacy Study of Inhaled Carbon Monoxide to Treat Acute Respiratory Distress Syndrome (ARDS)

Brigham and Women's Hospital

NCT03799874

ACTIVE NOT RECRUITING NA 7 participants

Cardiovascular Magnetic Resonance Prognosticators in Pediatric Oncology Patients With Sepsis

St. Jude Children's Research Hospital

NCT05930418

ACTIVE NOT RECRUITING Phase 1 5 participants

Safety Study of Inhaled Carbon Monoxide to Treat Pneumonia and Sepsis-Induced Acute Respiratory Distress Syndrome (ARDS)

Brigham and Women's Hospital

NCT04870125

COMPLETED 367 participants

suPAR Michigan M2C2 Heterogeneity Validation Cohort Study

ViroGates A/S

NCT07466524

COMPLETED NA 224 participants

Early PP With HFNC Versus HFNC in COVID-19 Induced Moderate to Severe ARDS

Rush University Medical Center

NCT04325906

COMPLETED Phase 2 160 participants

Ganciclovir/Valganciclovir for Prevention of CMV Reactivation in Acute Injury of the Lung and Respiratory Failure

Fred Hutchinson Cancer Center

NCT01335932

COMPLETED Phase 2 150 participants

Anti-TF Antibody (ALT-836) to Treat Septic Patients With Acute Lung Injury or Acute Respiratory Distress Syndrome

Altor BioScience

NCT00879606

COMPLETED Phase 1 72 participants

A Study of APL-9 in Adults With Mild to Moderate ARDS Due to COVID-19

Apellis Pharmaceuticals

NCT04402060

COMPLETED NA 63 participants

Mechanical Ventilation, Directed by Esophageal Pressure Measurements, in Patients With Acute Lung Injury

Beth Israel Deaconess Medical Center

NCT00127491

COMPLETED 39 participants

Blood Volume Assessment in COVID-19 and Bacterial Sepsis

NYU Langone Health

NCT04517695

COMPLETED Phase 1 36 participants

A Phase 1/2 Study to Assess MultiStem® Therapy in Acute Respiratory Distress Syndrome

Healios K.K.

NCT02611609

COMPLETED NA 35 participants

Feeding the Critically Ill During Phases of Altered Redox Status

University of Illinois at Chicago

NCT03085615

COMPLETED Phase 1 20 participants

Iloprost Effects on Gas Exchange and Pulmonary Mechanics

University of Oklahoma

NCT01274481

COMPLETED Phase 1 18 participants

Effects of TNX-832 (Sunol cH36) in Subjects With Acute Lung Injury/Acute Respiratory Distress Syndrome

Altor BioScience

NCT01438853

COMPLETED NA 12 participants

Efficacy and Safety of a Lung Recruitment Protocol in Children With Acute Lung Injury

Boston Children's Hospital

NCT00830284

COMPLETED Phase 1 9 participants

Human Mesenchymal Stem Cells For Acute Respiratory Distress Syndrome

Michael A. Matthay

NCT01775774

COMPLETED 8 participants

The ASTERS Study: Assessing the Role of Sphingolipids in AcuTE Respiratory Distress Syndrome (ARDS)

Sturgill

NCT03654352

Phase Distribution

PhaseTrial count
Early Phase 1 6
Phase 2 10
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Acute Respiratory Distress Syndrome Trial Landscape

ClinicalTrials.gov lists 32 US studies indexed under Acute Respiratory Distress Syndrome, and 14 of those are currently open to recruitment — roughly 44% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Acute Respiratory Distress Syndrome shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 16 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Acute Respiratory Distress Syndrome is led by PPD Development with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 32 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Acute Respiratory Distress Syndrome?

PlainTrial tracks 32 US clinical trials for Acute Respiratory Distress Syndrome, of which 14 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Acute Respiratory Distress Syndrome?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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