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Acute Respiratory Distress Syndrome clinical trials
14 of 32 indexed Acute Respiratory Distress Syndrome trials are currently recruiting.
32 US clinical trials · 14 currently recruiting
Acute Respiratory Distress Syndrome is the subject of 32 registered US clinical trials on ClinicalTrials.gov, 14 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 16 in Phase 1-2 (earlier-stage). The most active sponsor is PPD Development, running 4 of these trials.
The research picture
Acute Respiratory Distress Syndrome has 32 registered US clinical trials, 14 of them open to new participants right now, about 44% of the total.
- 14
- recruiting participants now
- 44%
- of trials open to enrollment
- 2
- in Phase 3–4 (later-stage)
- 4
- top sponsor: PPD Development
Active & Recent Trials
32 total, page 1 of 1
Dead Space and Inhaled Nitric Oxide in Pediatric Acute Respiratory Distress Syndrome
Children's Hospital Los Angeles
NCT06690801
Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome
Beth Israel Deaconess Medical Center
NCT06066502
Extracellular Vesicle Treatment for Acute Respiratory Distress Syndrome (ARDS) (EXTINGUISH ARDS)
Direct Biologics
NCT05354141
JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS (Master Record)
PPD Development
NCT06703073
Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)
BioAegis Therapeutics
NCT05947955
ARDS in Children and ECMO Initiation Strategies Impact on Neurodevelopment (ASCEND)
University of Michigan
NCT05388708
JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort C: Bevacizumab
PPD Development
NCT06701656
JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort A: Vilobelimab
PPD Development
NCT06701682
JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort B: Paridiprubart
PPD Development
NCT06701669
The Effects of Music Therapy on Adult Patients Requiring Mechanical Ventilation in the ICU
Icahn School of Medicine at Mount Sinai
NCT03642002
Phase 2a Multiple Ascending Dose Study in Hospitalized Patients With Pneumonia.
Vasomune Therapeutics
NCT05123755
Anti-CD14 Treatment With IC14 in Hospitalized ARDS Patients
Implicit Bioscience
NCT06513949
Macrophage Programing in Acute Lung Injury: MiniBAL
William Janssen, MD
NCT05767671
The ARISE Study - Use of Vertical Positioning
University of Alabama at Birmingham
NCT07025421
Molecular Epidemiology of Acute Respiratory Distress Syndrome (ARDS)
Massachusetts General Hospital
NCT00006496
Safety and Efficacy Study of Inhaled Carbon Monoxide to Treat Acute Respiratory Distress Syndrome (ARDS)
Brigham and Women's Hospital
NCT03799874
Cardiovascular Magnetic Resonance Prognosticators in Pediatric Oncology Patients With Sepsis
St. Jude Children's Research Hospital
NCT05930418
Safety Study of Inhaled Carbon Monoxide to Treat Pneumonia and Sepsis-Induced Acute Respiratory Distress Syndrome (ARDS)
Brigham and Women's Hospital
NCT04870125
suPAR Michigan M2C2 Heterogeneity Validation Cohort Study
ViroGates A/S
NCT07466524
Early PP With HFNC Versus HFNC in COVID-19 Induced Moderate to Severe ARDS
Rush University Medical Center
NCT04325906
Ganciclovir/Valganciclovir for Prevention of CMV Reactivation in Acute Injury of the Lung and Respiratory Failure
Fred Hutchinson Cancer Center
NCT01335932
Anti-TF Antibody (ALT-836) to Treat Septic Patients With Acute Lung Injury or Acute Respiratory Distress Syndrome
Altor BioScience
NCT00879606
A Study of APL-9 in Adults With Mild to Moderate ARDS Due to COVID-19
Apellis Pharmaceuticals
NCT04402060
Mechanical Ventilation, Directed by Esophageal Pressure Measurements, in Patients With Acute Lung Injury
Beth Israel Deaconess Medical Center
NCT00127491
Blood Volume Assessment in COVID-19 and Bacterial Sepsis
NYU Langone Health
NCT04517695
A Phase 1/2 Study to Assess MultiStem® Therapy in Acute Respiratory Distress Syndrome
Healios K.K.
NCT02611609
Feeding the Critically Ill During Phases of Altered Redox Status
University of Illinois at Chicago
NCT03085615
Iloprost Effects on Gas Exchange and Pulmonary Mechanics
University of Oklahoma
NCT01274481
Effects of TNX-832 (Sunol cH36) in Subjects With Acute Lung Injury/Acute Respiratory Distress Syndrome
Altor BioScience
NCT01438853
Efficacy and Safety of a Lung Recruitment Protocol in Children With Acute Lung Injury
Boston Children's Hospital
NCT00830284
Human Mesenchymal Stem Cells For Acute Respiratory Distress Syndrome
Michael A. Matthay
NCT01775774
The ASTERS Study: Assessing the Role of Sphingolipids in AcuTE Respiratory Distress Syndrome (ARDS)
Sturgill
NCT03654352
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 6 |
| Phase 2 | 10 |
| Phase 3 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Acute Respiratory Distress Syndrome Trial Landscape
32 indexed Acute Respiratory Distress Syndrome studies · 14 recruiting (44%).
Phase mix: 2 late (III/IV) vs 16 early (I/II).
Top sponsor: PPD Development (4 trials), 9 others listed. 32 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Acute Respiratory Distress Syndrome?
PlainTrial tracks 32 US clinical trials for Acute Respiratory Distress Syndrome, of which 14 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Acute Respiratory Distress Syndrome?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.