Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Depressive Disorder: early-phase trial registry
15 of 48 indexed Depressive Disorder trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #297 of 28,707 conditions by registered trial count.
48 US clinical trials · 15 currently recruiting · #297 of 28,707 conditions by registered trial count
Depressive Disorder: 48 US clinical trials tracked, 15 recruiting.
Depressive Disorder is the subject of 48 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most active sponsor is Mclean Hospital, running 2 of these trials.
Enrollment posture brief
Registry condition depressive-disorder
OPEN 15 | RECR 31% | LATE 4 | EARLY 12 | RANK #297 | SPON 2
Volume-matched condition peers
Nearest open-share peer: Aortic Valve Disease (31% recruiting · 16 trials)
Depressive Disorder lists 15 open slots (31% of 48 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Depressive Disorder on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
-
Depressive Disorder is recruiting below its size-band peers.
15 of 48 indexed trials (31.3%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
-
Sponsorship of Depressive Disorder trials is spread across many organizations.
Mclean Hospital accounts for 2 of 48 trials (4.2%). 40 distinct sponsors appear on at least one study for this condition label.
-
Typical Depressive Disorder enrolment sits around 90 participants.
Median target enrolment is 90 among the 48 trials that report a genuine target (sentinel values excluded). 25 of those (52.1%) plan for fewer than 100 participants.
-
Depressive Disorder research is mostly interventional.
42 interventional and 6 observational studies make up this index (87.5% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
48 total, page 1 of 1
Unified Protocol: Community Connections
University of Miami
NCT06038721
Ketamine Treatment Plans for Chronic Conditions
RIVER Foundation
NCT06038409
Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes
Colorado State University
NCT05543083
Whole Health in VA Mental Health: Omnis Salutis
VA Office of Research and Development
NCT05400252
Reward Processing and Depressive Subtypes: Identifying Neural Biotypes
San Francisco Veterans Affairs Medical Center
NCT06080646
Research Evaluating Vagal Excitation AND Anatomical Links
University of Minnesota
NCT06143293
Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality
Weill Medical College of Cornell University
NCT05925322
Measurement-Based Care (MBC) Implementation, Effectiveness, and Mechanisms of Change
Carilion Clinic
NCT06671158
A Mental Health Services Engagement Program for Racial and Ethnic Minority Young Adults
New York University
NCT06508450
Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness
Massachusetts General Hospital
NCT05962879
Mindfulness Engaged Neurostimulation for Depression
University of California, San Diego
NCT06399406
Depressed Mood Improvement Through Nicotine Dosing 3
Vanderbilt University Medical Center
NCT05746273
Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
National Institute of Mental Health (NIMH)
NCT06511908
Enhancing Brain And Mental Health Through Breathing Practice
Mayo Clinic
NCT07369752
The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects
Yale University
NCT05786066
Intervention to Prevent Peer Violence & Depressive Symptoms Among At-Risk Adolescents
Rhode Island Hospital
NCT03626103
Depressed Mood Improvement Through Nicotine Dosing-3 (Depressed MIND3) Extension
Vanderbilt University Medical Center
NCT05746546
Imaging to Improve Brain Stimulation
VA Office of Research and Development
NCT04016402
PRISM for Depression and Anxiety in Young Adults With Cancer
Dana-Farber Cancer Institute
NCT06502483
Harnessing Mobile Technology to Reduce Mental Health Disorders in College Populations
Washington University School of Medicine
NCT04162847
Transdiagnostic Behavioral Activation Therapy for Youth Anxiety and Depression
Rutgers University
NCT01829100
Study of the Safety and Efficacy of Fixed-dose Brexpiprazole (OPC-34712) as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder With and Without Anxious Distress
Otsuka Pharmaceutical Development & Commercialization
NCT02196506
Sleep Signal Analysis for Current Major Depressive Episode (SAMDE)
Medibio Limited
NCT05708222
Optimizing Electroconvulsive Therapy for Depression
New York State Psychiatric Institute
NCT00045916
An Eight-Week Study Evaluating the Efficacy and Tolerability of Two Doses of SSR149415 in Outpatients With Major Depressive Disorder
Sanofi
NCT00358631
Depression Attention for Women Now (The DAWN Study)
University of Washington
NCT01096316
Virtual Reality Job Interview Training in Severe Mental Illness
University of Michigan
NCT03049813
An Efficacy, Safety and Tolerability Study of JNJ-42165279 in Participants With Major Depressive Disorder With Anxious Distress
Janssen Research & Development
NCT02498392
Magnetic Stimulation Therapy for Treating Vascular Depression
University of Iowa
NCT00044798
Study to Evaluate TNX-601 ER Monotherapy Versus Placebo in Patients With Major Depressive Disorder (MDD)
Tonix Pharmaceuticals
NCT05686408
Flourishing and Virtue in Cognitive-Behavioral Therapy for Anxiety and Depressive Disorders
Boston University Charles River Campus
NCT05120232
Low Field Magnetic Stimulation (LFMS) in Subjects With Treatment-Resistant Depression (TRD)
Tal Medical
NCT02452892
Text-Message-Based Depression Prevention for High-Risk Youth in the ED
Rhode Island Hospital
NCT02332239
Multifaceted Depression and Cardiovascular Program
University of Southern California
NCT02069912
Feasibility of Collateral Information Review and Its Impact on Clinical Decision-Making
Mclean Hospital
NCT04635748
Telephone Administered Psychotherapy for the Treatment of Depression for Veterans in Rural Areas
US Department of Veterans Affairs
NCT00223652
Family Promoting Positive Emotions Pilot Study
Vanderbilt University
NCT05223842
Insulin Resistance in Patients With Major Depression
Stanford University
NCT01106313
Improving Retention of Hispanics Receiving Antidepressant Therapy
New York State Psychiatric Institute
NCT00057642
Effect of Nicotine on Brain Reward Pathways
Mclean Hospital
NCT02346539
Effects of Therapist Behavior on the Treatment of Depressed Adolescents
University of Denver
NCT00073359
Group Therapy for Women Prisoners With Comorbid Substance Use and Depression
Brown University
NCT00606996
Acute Aerobic Exercise and Neuroplasticity in Depression
Medical University of South Carolina
NCT02839837
A Study To Evaluate The Effect Of WELLBUTRIN XL On Intraocular Pressure
GlaxoSmithKline
NCT00439868
Memantine Augmentation of Antidepressants
University of Massachusetts, Worcester
NCT00344682
EnBrace HR for Depression Treatment and Prevention in Women Trying to Conceive and Early Pregnancy
Massachusetts General Hospital
NCT02676882
Duloxetine for the Treatment of Dysthymia
Stanford University
NCT00185575
TMS for Adults With Autism and Depression
Medical University of South Carolina
NCT02939560
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 9 |
| Phase 3 | 2 |
| Phase 4 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Depressive Disorder records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Depressive Disorder trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Depressive Disorder page
48 registered trials, 15 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 15 Depressive Disorder trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Mclean Hospital sponsors the most Depressive Disorder trials on record, review their full trial history before evaluating a specific study. See Mclean Hospital's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Depressive Disorder condition card totals 48 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.