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Depressive Disorder clinical trials
Every US clinical trial registered for Depressive Disorder — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
48 US clinical trials · 15 currently recruiting
The research picture
Depressive Disorder has 48 registered US clinical trials, 15 of them open to new participants right now — about 31% of the total.
- 15
- recruiting participants now
- 31%
- of trials open to enrollment
- 4
- in Phase 3–4 (later-stage)
- 2
- top sponsor: Mclean Hospital
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Unified Protocol: Community Connections
University of Miami
NCT06038721
Ketamine Treatment Plans for Chronic Conditions
RIVER Foundation
NCT06038409
Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes
Colorado State University
NCT05543083
Whole Health in VA Mental Health: Omnis Salutis
VA Office of Research and Development
NCT05400252
Reward Processing and Depressive Subtypes: Identifying Neural Biotypes
San Francisco Veterans Affairs Medical Center
NCT06080646
RESEARCH EVALUATING VAGAL EXCITATION AND ANATOMICAL LINKS
University of Minnesota
NCT06143293
Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality
Weill Medical College of Cornell University
NCT05925322
Measurement-Based Care (MBC) Implementation, Effectiveness, and Mechanisms of Change
Carilion Clinic
NCT06671158
A Mental Health Services Engagement Program for Racial and Ethnic Minority Young Adults
New York University
NCT06508450
Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness
Massachusetts General Hospital
NCT05962879
Mindfulness Engaged Neurostimulation for Depression
University of California, San Diego
NCT06399406
Depressed Mood Improvement Through Nicotine Dosing 3
Vanderbilt University Medical Center
NCT05746273
Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
National Institute of Mental Health (NIMH)
NCT06511908
Enhancing Brain And Mental Health Through Breathing Practice
Mayo Clinic
NCT07369752
The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects
Yale University
NCT05786066
Intervention to Prevent Peer Violence & Depressive Symptoms Among At-Risk Adolescents
Rhode Island Hospital
NCT03626103
Depressed Mood Improvement Through Nicotine Dosing-3 (Depressed MIND3) Extension
Vanderbilt University Medical Center
NCT05746546
Imaging to Improve Brain Stimulation
VA Office of Research and Development
NCT04016402
PRISM for Depression and Anxiety in Young Adults With Cancer
Dana-Farber Cancer Institute
NCT06502483
Harnessing Mobile Technology to Reduce Mental Health Disorders in College Populations
Washington University School of Medicine
NCT04162847
Transdiagnostic Behavioral Activation Therapy for Youth Anxiety and Depression
Rutgers University
NCT01829100
Study of the Safety and Efficacy of Fixed-dose Brexpiprazole (OPC-34712) as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder With and Without Anxious Distress
Otsuka Pharmaceutical Development & Commercialization
NCT02196506
Sleep Signal Analysis for Current Major Depressive Episode (SAMDE)
Medibio Limited
NCT05708222
Optimizing Electroconvulsive Therapy for Depression
New York State Psychiatric Institute
NCT00045916
An Eight-Week Study Evaluating the Efficacy and Tolerability of Two Doses of SSR149415 in Outpatients With Major Depressive Disorder
Sanofi
NCT00358631
Depression Attention for Women Now (The DAWN Study)
University of Washington
NCT01096316
Virtual Reality Job Interview Training in Severe Mental Illness
University of Michigan
NCT03049813
An Efficacy, Safety and Tolerability Study of JNJ-42165279 in Participants With Major Depressive Disorder With Anxious Distress
Janssen Research & Development
NCT02498392
Magnetic Stimulation Therapy for Treating Vascular Depression
University of Iowa
NCT00044798
Study to Evaluate TNX-601 ER Monotherapy Versus Placebo in Patients With Major Depressive Disorder (MDD)
Tonix Pharmaceuticals
NCT05686408
Flourishing and Virtue in Cognitive-Behavioral Therapy for Anxiety and Depressive Disorders
Boston University Charles River Campus
NCT05120232
Low Field Magnetic Stimulation (LFMS) in Subjects With Treatment-Resistant Depression (TRD)
Tal Medical
NCT02452892
Text-Message-Based Depression Prevention for High-Risk Youth in the ED
Rhode Island Hospital
NCT02332239
Multifaceted Depression and Cardiovascular Program
University of Southern California
NCT02069912
Feasibility of Collateral Information Review and Its Impact on Clinical Decision-Making
Mclean Hospital
NCT04635748
Telephone Administered Psychotherapy for the Treatment of Depression for Veterans in Rural Areas
US Department of Veterans Affairs
NCT00223652
Family Promoting Positive Emotions Pilot Study
Vanderbilt University
NCT05223842
Insulin Resistance in Patients With Major Depression
Stanford University
NCT01106313
Improving Retention of Hispanics Receiving Antidepressant Therapy
New York State Psychiatric Institute
NCT00057642
Effect of Nicotine on Brain Reward Pathways
Mclean Hospital
NCT02346539
Effects of Therapist Behavior on the Treatment of Depressed Adolescents
University of Denver
NCT00073359
Group Therapy for Women Prisoners With Comorbid Substance Use and Depression
Brown University
NCT00606996
Acute Aerobic Exercise and Neuroplasticity in Depression
Medical University of South Carolina
NCT02839837
A Study To Evaluate The Effect Of WELLBUTRIN XL On Intraocular Pressure
GlaxoSmithKline
NCT00439868
Memantine Augmentation of Antidepressants
University of Massachusetts, Worcester
NCT00344682
EnBrace HR for Depression Treatment and Prevention in Women Trying to Conceive and Early Pregnancy
Massachusetts General Hospital
NCT02676882
Duloxetine for the Treatment of Dysthymia
Stanford University
NCT00185575
TMS for Adults With Autism and Depression
Medical University of South Carolina
NCT02939560
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 9 |
| Phase 3 | 2 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Depressive Disorder Trial Landscape
ClinicalTrials.gov lists 48 US studies indexed under Depressive Disorder, and 15 of those are currently open to recruitment — roughly 31% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Depressive Disorder shows 4 late-stage studies (Phase 3 and Phase 4 combined) alongside 12 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Depressive Disorder is led by Mclean Hospital with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 48 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Depressive Disorder?
PlainTrial tracks 48 US clinical trials for Depressive Disorder, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Depressive Disorder?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.