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ClinicalTrials.gov 29 recruiting now official registry

Myelofibrosis clinical trials

29 of 62 indexed Myelofibrosis trials are currently recruiting.

62 US clinical trials · 29 currently recruiting

Myelofibrosis is the subject of 62 registered US clinical trials on ClinicalTrials.gov, 29 of them currently open to new participants. 7 are in Phase 3-4 (later-stage) and 47 in Phase 1-2 (earlier-stage). The most active sponsor is Incyte Corporation, running 4 of these trials.

The research picture

Myelofibrosis has 62 registered US clinical trials, 29 of them open to new participants right now, about 47% of the total.

29
recruiting participants now
47%
of trials open to enrollment
7
in Phase 3–4 (later-stage)
4
top sponsor: Incyte Corporation
Phase 130Phase 217Phase 37

Active & Recent Trials

62 total, page 1 of 2

RECRUITING 5,000 participants

MPN PROGRESSion Registry: Observational Study Tracking Symptoms, Treatments, and Disease Progression in People With Myeloproliferative Neoplasms (MPNs)

MPN Research Foundation

NCT07362225

RECRUITING 650 participants

Prospective Assessment of Allogeneic Hematopoietic Cell Transplantation in Patients With Myelofibrosis

Center for International Blood and Marrow Transplant Research

NCT02934477

RECRUITING Phase 3 600 participants

Study of Navtemadlin add-on to Ruxolitinib in JAK Inhibitor-Naïve Patients With Myelofibrosis Who Have a Suboptimal Response to Ruxolitinib

Kartos Therapeutics

NCT06479135

RECRUITING Phase 3 400 participants

A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017)

Merck Sharp & Dohme

NCT06351631

RECRUITING Phase 2 300 participants

Myeloablative Allo HSCT With Related or Unrelated Donor for Heme Disorders

Masonic Cancer Center, University of Minnesota

NCT03314974

RECRUITING Phase 1 240 participants

A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis

Sumitomo Pharma America

NCT04176198

RECRUITING Phase 2 216 participants

CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplant

City of Hope Medical Center

NCT06059391

RECRUITING NA 207 participants

A Telehealth Advance Care Planning Intervention

University of Rochester

NCT05875805

RECRUITING NA 200 participants

Umbilical Cord Blood Transplantation Using a Myeloablative Preparative Regimen for Hematological Diseases

Masonic Cancer Center, University of Minnesota

NCT01962636

RECRUITING 192 participants

Quantitative MRI for Myelofibrosis

University of Michigan Rogel Cancer Center

NCT01973881

RECRUITING Phase 1 150 participants

Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia

Disc Medicine

NCT05320198

RECRUITING Phase 2 121 participants

Study of TL-895 in Subjects With Myelofibrosis or Indolent Systemic Mastocytosis

Telios Pharma

NCT04655118

RECRUITING Phase 1 100 participants

Study of Oral Administration of LP-118 in Patients With Relapsed or Refractory CLL, SLL, MDS, MDS/MPN, AML, CMML-2, MPN-BP, ALL, MF, NHL, RT, MM or T-PLL.

Newave Pharmaceutical

NCT04771572

RECRUITING Phase 1 75 participants

Dual BET and CBP/p300 Inhibitor in Patients With Targeted Advanced Solid Tumors and Hematological Malignancies

Epigenetix

NCT05488548

RECRUITING Phase 1 70 participants

Study of TL-895 Combined With Ruxolitinib in JAKi Treatment-Naïve MF Subjects and Subjects With MF Who Have a Suboptimal Response to Ruxolitinib

Telios Pharma

NCT05280509

RECRUITING Phase 2 58 participants

A Study of Selinexor Monotherapy in Subjects With JAK Inhibitor-naïve Myelofibrosis and Moderate Thrombocytopenia

Karyopharm Therapeutics

NCT05980806

RECRUITING Phase 1 44 participants

Study of Tagraxofusp for Post-Transplant Maintenance for Patients With CD 123+ AML, MDS, MF and CMML (HSCT 002)

Karen Ballen, MD

NCT05233618

RECRUITING Phase 1 37 participants

A Study of Ruxolitinib in Combination With Ulixertinib in People With Myelofibrosis

Memorial Sloan Kettering Cancer Center

NCT06773195

RECRUITING Phase 1 36 participants

A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of Imetelstat in Combination With Ruxolitinib in Participants With Myelofibrosis

Geron Corporation

NCT05371964

RECRUITING Phase 2 30 participants

High Dose Ruxolitinib and Allogeneic Stem Cell Transplantation in Myelofibrosis Patients With Splenomegaly

M.D. Anderson Cancer Center

NCT06345495

RECRUITING Phase 2 30 participants

Curcumin to Improve Inflammation and Symptoms in Patients With Clonal Cytopenia of Undetermined Significance, Low Risk Myelodysplastic Syndrome, and Myeloproliferative Neoplasms

University of Southern California

NCT06063486

RECRUITING Phase 1 28 participants

Momelotinib During and After HCT in Myelofibrosis

Massachusetts General Hospital

NCT07104799

RECRUITING Phase 1 27 participants

An Optimal Dose Finding Study of N-Acetylcysteine in Patients With Myeloproliferative Neoplasms

University of California, Irvine

NCT05123365

RECRUITING Phase 1 26 participants

A Safety and Tolerability Study of Jaktinib

Suzhou Zelgen Biopharmaceuticals Co.

NCT05279001

RECRUITING Phase 1 24 participants

Leading in MPNs Beyond Ruxolitinib in Combo With T-Regs

Cellenkos

NCT05423691

RECRUITING Early Phase 1 24 participants

Hyperbaric Oxygen Therapy and Allogeneic Peripheral Blood Stem Cell (PBSC) Transplant

Omar Aljitawi

NCT03964506

RECRUITING Phase 1 18 participants

Allogeneic Hematopoietic Cell Transplantation With Pegylated Interferon Alfa-2a for Primary and Secondary Myelofibrosis

University of Utah

NCT05535764

RECRUITING Phase 1 10 participants

Mutant CALR-peptide Based Vaccine in Patients With Mutated CALR Myeloproliferative Neoplasm

Marina Kremyanskaya

NCT05025488

RECRUITING Phase 1 10 participants

Treating Anemia in Myelofibrosis With Repurposed Drugs (Nelfinavir) That Restore Iron Delivery to the Bone Marrow

University of California, Irvine

NCT07281781

ACTIVE NOT RECRUITING Phase 3 430 participants

Phase 3 Study of Pelabresib (CPI-0610) in Myelofibrosis (MF) (MANIFEST-2)

Novartis Pharmaceuticals

NCT04603495

ACTIVE NOT RECRUITING Phase 3 353 participants

Study of Selinexor in Combination With Ruxolitinib in Myelofibrosis

Karyopharm Therapeutics

NCT04562389

ACTIVE NOT RECRUITING Phase 3 327 participants

A Study Comparing Imetelstat Versus Best Available Therapy for the Treatment of Intermediate-2 or High-risk Myelofibrosis (MF) Who Have Not Responded to Janus Kinase (JAK)-Inhibitor Treatment

Geron Corporation

NCT04576156

ACTIVE NOT RECRUITING Phase 3 313 participants

An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK2 Inhibitor Therapy and Who Require Red Blood Cell Transfusions

Celgene

NCT04717414

ACTIVE NOT RECRUITING Phase 1 216 participants

A Study to Assess the Safety and Tolerability of BMS-986158 Alone and in Combination With Either Ruxolitinib or Fedratinib in Participants With Blood Cancer (Myelofibrosis)

Bristol-Myers Squibb

NCT04817007

ACTIVE NOT RECRUITING Phase 1 140 participants

Safety and Tolerability Study of INCB057643 in Participants With Myelofibrosis and Other Advanced Myeloid Neoplasms

Incyte Corporation

NCT04279847

ACTIVE NOT RECRUITING Phase 2 112 participants

A Study to Evaluate Single Agent Selinexor Versus Physician's Choice in Participants With Previously Treated Myelofibrosis

Karyopharm Therapeutics

NCT04562870

ACTIVE NOT RECRUITING Phase 1 72 participants

Hu8F4 in Treating Patients With Advanced Hematologic Malignancies

M.D. Anderson Cancer Center

NCT02530034

ACTIVE NOT RECRUITING Phase 2 30 participants

A Clinical Study to Test the Effects of Ruxolitinib And Thalidomide Combination for Patients With Myelofibrosis

Memorial Sloan Kettering Cancer Center

NCT03069326

ACTIVE NOT RECRUITING NA 30 participants

Geriatric Optimization Plan to Improve Survival in Older Adult Allogeneic Hematopoietic Cell Transplant Candidates, OTIS Study

Ohio State University Comprehensive Cancer Center

NCT05972577

ACTIVE NOT RECRUITING Phase 2 25 participants

Topotecan Hydrochloride and Carboplatin With or Without Veliparib in Treating Advanced Myeloproliferative Disorders and Acute Myeloid Leukemia or Chronic Myelomonocytic Leukemia

National Cancer Institute (NCI)

NCT03289910

ACTIVE NOT RECRUITING Phase 1 25 participants

A Phase 1 Trial of CD25/Treg-depleted DLI Plus Ipilimumab for Myeloid Disease Relapse After Matched-HCT

Dana-Farber Cancer Institute

NCT03912064

ACTIVE NOT RECRUITING Phase 3 21 participants

Haploidentical Allogeneic Peripheral Blood Transplantation: Examining Checkpoint Immune Regulators' Expression

Dartmouth-Hitchcock Medical Center

NCT03480360

ACTIVE NOT RECRUITING Phase 2 21 participants

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Oral GB2064 in Participants With Myelofibrosis

Galecto Biotech AB

NCT04679870

ACTIVE NOT RECRUITING Phase 2 18 participants

A Rollover Study to Provide Continued Treatment for Participants Previously Enrolled in Studies of Itacitinib

Incyte Corporation

NCT04640025

ACTIVE NOT RECRUITING Phase 1 16 participants

Combination Navitoclax, Venetoclax and Decitabine for Advanced Myeloid Neoplasms

Jacqueline Garcia, MD

NCT05455294

ACTIVE NOT RECRUITING Phase 2 7 participants

Triplex Vaccine in Preventing CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplantation

City of Hope Medical Center

NCT04060277

COMPLETED Phase 1 154 participants

Open Label Ruxolitinib (INCB018424) in Patients With Myelofibrosis and Post Polycythemia Vera/Essential Thrombocythemia Myelofibrosis

Incyte Corporation

NCT00509899

COMPLETED 123 participants

Genetic Analysis of Gray Platelet Syndrome

National Human Genome Research Institute (NHGRI)

NCT00069680

COMPLETED Phase 1 100 participants

Study of LY2784544 Testing Alternative Dosing in Participants With Myeloproliferative Neoplasms

Eli Lilly and Company

NCT01520220

COMPLETED Phase 1 82 participants

Tagraxofusp (SL-401) in Participants With Chronic Myelomonocytic Leukemia (CMML) and Myelofibrosis (MF)

Stemline Therapeutics

NCT02268253

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Phase Distribution

PhaseTrial count
Phase 1 30
Phase 2 17
Phase 3 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Myelofibrosis Trial Landscape

62 indexed Myelofibrosis studies · 29 recruiting (47%).

Phase mix: 7 late (III/IV) vs 47 early (I/II).

Top sponsor: Incyte Corporation (4 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Myelofibrosis?

PlainTrial tracks 62 US clinical trials for Myelofibrosis, of which 29 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Myelofibrosis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.