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Delirium clinical trials
24 of 63 indexed Delirium trials are currently recruiting.
63 US clinical trials · 24 currently recruiting
Delirium is the subject of 63 registered US clinical trials on ClinicalTrials.gov, 24 of them currently open to new participants. 9 are in Phase 3-4 (later-stage) and 10 in Phase 1-2 (earlier-stage). The most active sponsor is Vanderbilt University Medical Center, running 5 of these trials.
The research picture
Delirium has 63 registered US clinical trials, 24 of them open to new participants right now, about 38% of the total.
- 24
- recruiting participants now
- 38%
- of trials open to enrollment
- 9
- in Phase 3–4 (later-stage)
- 5
- top sponsor: Vanderbilt University Medical Center
Active & Recent Trials
63 total, page 1 of 2
Modifying the Inpatient Environment to Reduce Delirium in Older Adults
Farhaan S. Vahidy
NCT06736951
Behavioral Economic & Staffing Strategies in the ICU
University of Nebraska
NCT06184945
Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders
University of Michigan
NCT05929703
Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep (MINDDS II)
Massachusetts General Hospital
NCT06192615
Researching Efficient Approaches to Delirium Identification-Sustaining Effective Translation
Penn State University
NCT05915377
CTSN Embolic Protection Trial
Icahn School of Medicine at Mount Sinai
NCT06027788
Delirium and Neuropsychological Recovery Among Emergency General Surgery Survivors
University of Wisconsin, Madison
NCT05373017
Delirium Reduction With Ramelteon
Centennial Medical Center
NCT05069428
Interventions for Postoperative Delirium: Biomarker-3
University of Wisconsin, Madison
NCT03124303
Automating Delirium Severity in the ICU
Mayo Clinic
NCT06172491
Pervasive Sensing and AI in Intelligent ICU
University of Florida
NCT05127265
Goal-Directed Sedation in Mechanically Ventilated Infants and Children
Vanderbilt University Medical Center
NCT04801589
Ceribell Delirium Data Collection Study
Ceribell
NCT04962815
Neurosteer Bedside Monitoring System
Icahn School of Medicine at Mount Sinai
NCT06718764
A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors
University of Washington
NCT06411561
Trazodone vs. Quetiapine for the Treatment of ICU Delirium
University of Southern California
NCT05307003
Delirium Identification in Older Patients With Alzheimer's and Other Related Dementias In the Emergency Department
Ohio State University
NCT06326424
Regional Nerve Blocks to Improve Analgesia and Recovery in Older Adults Undergoing Spinal Fusion
University of Iowa
NCT05461092
Simultaneous Recumbent Cycling and Cognitive Training
University of Missouri, Kansas City
NCT04556227
Mitigating Delirium With Fluvoxamine Treatment for Non-Cardiac Surgery
Washington University School of Medicine
NCT06969287
Managing Agitated Delirium With Neuroleptics and Anti-Epileptics as a Neuroleptic Sparing Strategy
M.D. Anderson Cancer Center
NCT05431595
Delirium in Neurodegenerative Disease Patients: A Music Therapy Intervention for Hospital Care
Boston Medical Center
NCT07137949
VoiceLove Digital Therapy for Delirium in the ICU
The Methodist Hospital Research Institute
NCT07218484
TaVNS for Delirium
Stony Brook University
NCT07258082
Benzodiazepine-free Cardiac Anesthesia for Reduction of Postoperative Delirium
Population Health Research Institute
NCT03928236
Delirium in Children Undergoing Stem Cell Transplantation
Weill Medical College of Cornell University
NCT04937400
PANDORA: Delirium Prevention After Cardiac Surgery Using IV Acetaminophen to Prevent Postoperative Delirium in Older Cardiac Surgical Patients
Beth Israel Deaconess Medical Center
NCT04093219
The BRAIN Intensive Care Unit (ICU) Study: Bringing to Light the Risk Factors
Vanderbilt University Medical Center
NCT00392795
Vasopressor SAT Study
University of Chicago
NCT03182335
Illuminating Neuropsychological Dysfunction and Systemic Inflammatory Mechanisms Gleaned After Hospitalization in Trauma-ICU Study
Vanderbilt University Medical Center
NCT03098459
Intelligent Intensive Care Unit
University of Florida
NCT02465307
SLeep and OPioid UsE in Patients Undergoing Total Knee Arthroplasty
Scripps Health
NCT04247646
Haloperidol and Lorazepam in Controlling Symptoms of Persistent Agitated Delirium in Patients With Advanced Cancer Undergoing Palliative Care
M.D. Anderson Cancer Center
NCT03743649
Digital Rehabilitation Environment Augmenting Medical System
University of Florida
NCT03385993
Fundamental Intelligent Building Blocks of the Intensive Care Unit (ICU) of the Future: Intelligent ICU of the Future
University of Florida
NCT03905668
Haloperidol With or Without Chlorpromazine in Treating Delirium in Patients With Advanced, Metastatic, or Recurrent Cancer
M.D. Anderson Cancer Center
NCT03021486
Driving Rehabilitation and Innovation for Evaluating Risk in Post-Intensive Care Unit Survivors
Baylor Research Institute
NCT05999903
MIND-ICU Study: Delirium and Dementia in Veterans Surviving ICU Care
VA Office of Research and Development
NCT00400062
The Modifying the Impact of ICU-Associated Neurological Dysfunction-USA (MIND-USA) Study
Vanderbilt University Medical Center
NCT01211522
Investigation of Sleep in the Intensive Care Unit
Massachusetts General Hospital
NCT03355053
The MENDS2 Study, Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients With Acute Respiratory Failure
Vanderbilt University Medical Center
NCT01739933
e-CHAMP: Enhancing Care for Hospitalized Older Adults With Memory Problems
Indiana University
NCT00182832
Implementation of Multidisciplinary Assessments for Geriatric Patients in an ED Observation Unit
Ohio State University
NCT04068311
Care.Coach Avatars for Improvement of Outcomes in Hospitalized Elders, Including Mitigation of Falls and Delirium: a Multi-Site Clinical Study
Victor Wang
NCT03832192
Improving the Recovery and Outcome Every Day After the ICU
Indiana University
NCT03095417
Nursing Assistant Intervention to Prevent Delirium in Nursing Homes
Jewish Home & Hospital Lifecare System
NCT02994979
Shaping Anesthetic Techniques to Reduce Post-operative Delirium
Johns Hopkins University
NCT03133845
Anesthetic Depth and Postoperative Delirium Trial - 2
University of California, San Francisco
NCT01983384
Post-Operative Delirium in Elderly Surgical Patients
Johns Hopkins University
NCT00590707
Preventing Post-Operative Delirium in Patients Undergoing a Pneumonectomy, Esophagectomy or Thoracotomy
Indiana University
NCT02213900
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 8 |
| Phase 3 | 6 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Delirium Trial Landscape
63 indexed Delirium studies · 24 recruiting (38%).
Phase mix: 9 late (III/IV) vs 10 early (I/II).
Top sponsor: Vanderbilt University Medical Center (5 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Delirium?
PlainTrial tracks 63 US clinical trials for Delirium, of which 24 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Delirium?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.