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Delirium
Open-data reference.
63 US clinical trials · 24 currently recruiting
Active & Recent Trials
Modifying the Inpatient Environment to Reduce Delirium in Older Adults
Farhaan S. Vahidy
NCT06736951
Behavioral Economic & Staffing Strategies in the ICU
University of Nebraska
NCT06184945
Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders
University of Michigan
NCT05929703
Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep (MINDDS II)
Massachusetts General Hospital
NCT06192615
Researching Efficient Approaches to Delirium Identification-Sustaining Effective Translation
Penn State University
NCT05915377
CTSN Embolic Protection Trial
Icahn School of Medicine at Mount Sinai
NCT06027788
Delirium and Neuropsychological Recovery Among Emergency General Surgery Survivors
University of Wisconsin, Madison
NCT05373017
Delirium Reduction With Ramelteon
Centennial Medical Center
NCT05069428
Interventions for Postoperative Delirium: Biomarker-3
University of Wisconsin, Madison
NCT03124303
Automating Delirium Severity in the ICU
Mayo Clinic
NCT06172491
Pervasive Sensing and AI in Intelligent ICU
University of Florida
NCT05127265
Goal-Directed Sedation in Mechanically Ventilated Infants and Children
Vanderbilt University Medical Center
NCT04801589
Ceribell Delirium Data Collection Study
Ceribell
NCT04962815
Neurosteer Bedside Monitoring System
Icahn School of Medicine at Mount Sinai
NCT06718764
A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors
University of Washington
NCT06411561
Trazodone vs. Quetiapine for the Treatment of ICU Delirium
University of Southern California
NCT05307003
Delirium Identification in Older Patients With Alzheimer's and Other Related Dementias In the Emergency Department
Ohio State University
NCT06326424
Regional Nerve Blocks to Improve Analgesia and Recovery in Older Adults Undergoing Spinal Fusion
University of Iowa
NCT05461092
Simultaneous Recumbent Cycling and Cognitive Training
University of Missouri, Kansas City
NCT04556227
Mitigating Delirium With Fluvoxamine Treatment for Non-Cardiac Surgery
Washington University School of Medicine
NCT06969287
Managing Agitated Delirium With Neuroleptics and Anti-Epileptics as a Neuroleptic Sparing Strategy
M.D. Anderson Cancer Center
NCT05431595
Delirium in Neurodegenerative Disease Patients: A Music Therapy Intervention for Hospital Care
Boston Medical Center
NCT07137949
VoiceLove Digital Therapy for Delirium in the ICU
The Methodist Hospital Research Institute
NCT07218484
TaVNS for Delirium
Stony Brook University
NCT07258082
Benzodiazepine-free Cardiac Anesthesia for Reduction of Postoperative Delirium
Population Health Research Institute
NCT03928236
Delirium in Children Undergoing Stem Cell Transplantation
Weill Medical College of Cornell University
NCT04937400
PANDORA: Delirium Prevention After Cardiac Surgery Using IV Acetaminophen to Prevent Postoperative Delirium in Older Cardiac Surgical Patients
Beth Israel Deaconess Medical Center
NCT04093219
The BRAIN Intensive Care Unit (ICU) Study: Bringing to Light the Risk Factors
Vanderbilt University Medical Center
NCT00392795
Vasopressor SAT Study
University of Chicago
NCT03182335
Illuminating Neuropsychological Dysfunction and Systemic Inflammatory Mechanisms Gleaned After Hospitalization in Trauma-ICU Study
Vanderbilt University Medical Center
NCT03098459
Intelligent Intensive Care Unit
University of Florida
NCT02465307
SLeep and OPioid UsE in Patients Undergoing Total Knee Arthroplasty
Scripps Health
NCT04247646
Haloperidol and Lorazepam in Controlling Symptoms of Persistent Agitated Delirium in Patients With Advanced Cancer Undergoing Palliative Care
M.D. Anderson Cancer Center
NCT03743649
Digital Rehabilitation Environment Augmenting Medical System
University of Florida
NCT03385993
Fundamental Intelligent Building Blocks of the Intensive Care Unit (ICU) of the Future: Intelligent ICU of the Future
University of Florida
NCT03905668
Haloperidol With or Without Chlorpromazine in Treating Delirium in Patients With Advanced, Metastatic, or Recurrent Cancer
M.D. Anderson Cancer Center
NCT03021486
Driving Rehabilitation and Innovation for Evaluating Risk in Post-Intensive Care Unit Survivors
Baylor Research Institute
NCT05999903
MIND-ICU Study: Delirium and Dementia in Veterans Surviving ICU Care
VA Office of Research and Development
NCT00400062
The Modifying the Impact of ICU-Associated Neurological Dysfunction-USA (MIND-USA) Study
Vanderbilt University Medical Center
NCT01211522
Investigation of Sleep in the Intensive Care Unit
Massachusetts General Hospital
NCT03355053
The MENDS2 Study, Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients With Acute Respiratory Failure
Vanderbilt University Medical Center
NCT01739933
e-CHAMP: Enhancing Care for Hospitalized Older Adults With Memory Problems
Indiana University
NCT00182832
Implementation of Multidisciplinary Assessments for Geriatric Patients in an ED Observation Unit
Ohio State University
NCT04068311
Care.Coach Avatars for Improvement of Outcomes in Hospitalized Elders, Including Mitigation of Falls and Delirium: a Multi-Site Clinical Study
Victor Wang
NCT03832192
Improving the Recovery and Outcome Every Day After the ICU
Indiana University
NCT03095417
Nursing Assistant Intervention to Prevent Delirium in Nursing Homes
Jewish Home & Hospital Lifecare System
NCT02994979
Shaping Anesthetic Techniques to Reduce Post-operative Delirium
Johns Hopkins University
NCT03133845
Anesthetic Depth and Postoperative Delirium Trial - 2
University of California, San Francis
NCT01983384
Post-Operative Delirium in Elderly Surgical Patients
Johns Hopkins University
NCT00590707
Preventing Post-Operative Delirium in Patients Undergoing a Pneumonectomy, Esophagectomy or Thoracotomy
Indiana University
NCT02213900
Ketamine Infusion as Sedative Analgesic in Severe ARDS
Interfaith Medical Center
NCT04818827
Delirium in Mechanically Ventilated Patients
University of Chicago
NCT00919698
MENDS Study: Trial in Ventilated ICU Patients Comparing an Alpha2 Agonist Versus a Gamma Aminobutyric Acid (GABA)-Agonist to Determine Delirium Rates, Efficacy of Sedation, Analgesia and Discharge Cognitive Status
Vanderbilt University
NCT00095251
Does Nightly Dexmedetomidine Improve Sleep and Reduce Delirium in ICU Patients?
Maisonneuve-Rosemont Hospital
NCT01791296
High Dose Intravenous Thiamine for the Prevention of Delirium in Allogeneic Hematopoietic Stem Cell Transplantation
UNC Lineberger Comprehensive Cancer Center
NCT03263442
The Impact of Ketamine on Postoperative Cognitive Dysfunction, Delirium, and Renal Dysfunction
Mayo Clinic
NCT02554253
Feasibility and Acceptability of Using Weighted Blankets to Prevent and /or Mitigate Delirium
Virginia Commonwealth University
NCT06161480
Prevention of Early Postoperative Decline
Beth Israel Deaconess Medical Center
NCT02908464
Examining the Association Between Pre-existing Sleep Disturbance and Postoperative Delirium
Massachusetts General Hospital
NCT03498560
Remote Cognitive Assessment for Surgical Patients
University of California, San Francis
NCT05566275
Feasibility and Acceptability of ReCognitionVR-based Cognitive Stimulation in Surgical Patients
The Methodist Hospital Research Institute
NCT06232317
Pharmacokinetic Study Comparing Topical, Rectal, and Oral Quetiapine
Mayo Clinic
NCT02131545
Helping Older Persons Emerge Stronger
Ohio State University
NCT02863081
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 2 |
| Phase 2 | 8 |
| Phase 3 | 6 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Delirium Trial Landscape
ClinicalTrials.gov lists 63 US studies indexed under Delirium, and 24 of those are currently open to recruitment — roughly 38% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Delirium shows 9 late-stage studies (Phase 3 and Phase 4 combined) alongside 10 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Delirium is led by Vanderbilt University Medical Center with 5 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 63 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Delirium?
PlainTrial tracks 63 US clinical trials for Delirium, of which 24 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Delirium?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.