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ClinicalTrials.gov 15 recruiting now official registry

HIV/AIDS clinical trials

Every US clinical trial registered for HIV/AIDS — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

62 US clinical trials · 15 currently recruiting

The research picture

HIV/AIDS has 62 registered US clinical trials, 15 of them open to new participants right now — about 24% of the total.

15
recruiting participants now
24%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
7
top sponsor: University of California, San Francis

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 2,000,000 participants

Observational Pharmaco-Epidemiology Research & Analysis

Epividian

NCT03813862

RECRUITING NA 3,200 participants

MyPEEPS LITE Trial

Columbia University

NCT06741631

RECRUITING NA 1,500 participants

Improving the Organizational Social Context to Address Structural Racism and Discrimination

University of Pennsylvania

NCT06462807

RECRUITING NA 500 participants

MyPEEPS Mobile Plus: A Multi-Level HIV Prevention Intervention for Young MSM

Columbia University

NCT06741618

RECRUITING NA 420 participants

Community Health Workers And MHealth to ImProve Viral Suppression Plus (CHAMPS+)

Columbia University

NCT06472206

RECRUITING NA 418 participants

Project I Test: Implementing HIV Testing in Opioid Treatment Programs

Columbia University

NCT03135886

RECRUITING NA 360 participants

Women SHINE: Addressing Syndemics and HIV Among Women Through Tech-Based Peer Engagement

University of California, San Diego

NCT05509959

RECRUITING Phase 3 340 participants

Optimizing Tobacco Use Treatment for PLWHA

University of Pennsylvania

NCT04176172

RECRUITING NA 250 participants

ADELANTE: A Randomized Controlled Trial to Improve Engagement in Care for Latinos With HIV

Massachusetts General Hospital

NCT06274632

RECRUITING NA 200 participants

A Mobile Gaming App to Improve Adherence to PrEP

Rhode Island Hospital

NCT05762705

RECRUITING NA 141 participants

Appalachian Partnership to Reduce Disparities (Aim 2)

Wake Forest University Health Sciences

NCT04378439

RECRUITING Phase 2 110 participants

An Integrated Intervention Using a Pill Ingestible Sensor System

University of California, Los Angeles

NCT06480578

RECRUITING NA 80 participants

An mHealth Intervention to Improve Outcomes for Women With HIV/AIDS

University of Miami

NCT03738410

RECRUITING NA 60 participants

LinkPositively+ A Mobile Health App Delivered Intervention to Improve HIV Care Outcomes Among Black Women Affected by Mental Health and Violence

Guiding Right

NCT06458660

RECRUITING NA 40 participants

SCOPE Analytic Treatment Interruption Protocol

University of California, San Francis

NCT04359186

ACTIVE NOT RECRUITING NA 1,928 participants

ResIlience-based Stigma REdUction Program ("Rise-up")

University of South Carolina

NCT05174936

ACTIVE NOT RECRUITING NA 200 participants

Intervention for Virologic Suppression in Youth

University of California, San Francis

NCT05877729

ACTIVE NOT RECRUITING Phase 2 108 participants

Effects of Semaglutide in HIV-Associated Lipohypertrophy

Case Western Reserve University

NCT04019197

ACTIVE NOT RECRUITING Early Phase 1 100 participants

Impact of HIV-1 and Aging on Mucosal Vaccine Responses

VA Eastern Colorado Health Care System

NCT03729778

ACTIVE NOT RECRUITING NA 62 participants

Leveraging mHealth to Enable and Adapt CHW Strategies to Improve TB/HIV Patient Outcomes in SA

Johns Hopkins University

NCT04298905

ACTIVE NOT RECRUITING NA 30 participants

Robot-Assisted Rehabilitation After HIV-Associated Stroke: Botswana

University of Pennsylvania

NCT04488250

ACTIVE NOT RECRUITING Phase 1 11 participants

Combinatorial Therapy to Induce an HIV Remission

University of California, San Francis

NCT04357821

COMPLETED 6,613 participants

HIV Jail POC-AgAB Testings

Montefiore Medical Center

NCT04296331

COMPLETED NA 791 participants

Theory-based HIV Disclosure Intervention for Parents

University of South Carolina

NCT04051177

COMPLETED NA 682 participants

PositiveLinks: mHealth for DC Cohort

George Washington University

NCT04998019

COMPLETED NA 579 participants

Effectiveness of Peer Navigation and Contingency Management on Retention in HIV Care

University of California, Los Angeles

NCT02310893

COMPLETED NA 500 participants

Behavioral Intervention to Enhance HIV Test/Treat

University of Connecticut

NCT01752777

COMPLETED NA 478 participants

Integrating HIV and Hepatitis C Screening in an Urban Emergency Department

New York City Health and Hospitals Corporation

NCT03252483

COMPLETED NA 451 participants

Leveraging mHealth and Peers to Engage African- Americans and Latinxs in HIV Care (LEAN)

Johns Hopkins University

NCT03934437

COMPLETED 412 participants

COVID-19 in Patients With HIV

University of Missouri-Columbia

NCT04333953

COMPLETED 334 participants

Adolescent Master Protocol for Participants 18 Years of Age or Older - Lite

Harvard School of Public Health (HSPH)

NCT03279185

COMPLETED NA 306 participants

A Randomized Controlled Trial of an Antiretroviral Treatment Adherence Intervention for HIV+ African Americans

RAND

NCT03331978

COMPLETED NA 298 participants

A Nurse-led Intervention to Extend the HIV Treatment Cascade for Cardiovascular Disease Prevention

Case Western Reserve University

NCT03643705

COMPLETED NA 288 participants

Duo Partnership Adherence Commitment Therapy

University of California, San Francis

NCT02925949

COMPLETED 257 participants

MEMO-Medical Marijuana and Opioids Study

Albert Einstein College of Medicine

NCT03268551

COMPLETED NA 208 participants

ART-CHESS: A Mobile Health Application to Support People Living With HIV and Addiction

University of Wisconsin, Madison

NCT03873129

COMPLETED NA 197 participants

CASA: Care and Support Access in HIV Disease

University of Maryland

NCT02136680

COMPLETED NA 196 participants

Symptom Management Efficacy Study to Reduce Distal Neuropathic Pain

New York University

NCT03855111

COMPLETED NA 196 participants

Prevention and Risk: Treatment With a New Emphasis on Relationships

Hunter College of City University of New York

NCT03396367

COMPLETED NA 141 participants

Developing and Examining Evidenced-Based HIV Testing Messages

Virginia Commonwealth University

NCT03433053

COMPLETED NA 120 participants

Project RAP: Family-based HIV Prevention in the Juvenile Drug Court

University of California, San Francis

NCT01403298

COMPLETED NA 100 participants

iSTEP - an mHealth Physical Activity and Diet Intervention for Persons With HIV

University of California, San Diego

NCT03123731

COMPLETED NA 100 participants

Linking High-Risk Jail Detainees to HIV Pre-Exposure Prophylaxis: PrEP-LINK

University of Arkansas

NCT04064567

COMPLETED 80 participants

Transgender Youth and PrEP: PK, Safety, Uptake & Adherence - Intervention Development

Hektoen Institute for Medical Research

NCT04077138

COMPLETED NA 71 participants

Enhancing Sexual Safety: Couples' Communication and HIV Testing Among YMSM

Florida State University

NCT04289116

COMPLETED NA 65 participants

PlusCare: Mobile Platform to Increase Linkage to Care in Adolescents Living With HIV/AIDS

Dimagi

NCT03758066

COMPLETED 50 participants

Assessment of Cognitive Functioning as it Relates to Risk for Suicide in Veterans With HIV/AIDS

VA Eastern Colorado Health Care System

NCT01749007

COMPLETED Phase 1 49 participants

Transgender Youth and PrEP: PK, Safety, Uptake & Adherence - PK Study

Hektoen Institute for Medical Research

NCT03652623

COMPLETED 46 participants

Development of a Couple-Based Mobile Health Intervention for Enhancing HIV Care Engagement Outcomes (N'Gage)

University of California, San Francis

NCT03100643

COMPLETED Phase 1 41 participants

Body Compartment Pharmacokinetics of Anti-retroviral Agents That May be Considered for Future On-demand Peri-exposure HIV Prophylaxis Regimens

Emory University

NCT03976752

COMPLETED NA 40 participants

Trauma Informed Intervention to Support Engagement in HIV Care Among MSM (THRIVE+)

Massachusetts General Hospital

NCT05822206

COMPLETED NA 39 participants

Depression Intervention Among Gay and Bisexual Men Receiving Treatment for Methamphetamine Use

Friends Research Institute

NCT03864653

COMPLETED NA 31 participants

HIV+ Substance Users Released From Jail

University of Texas Southwestern Medical Center

NCT03834779

COMPLETED NA 30 participants

HIV Reengagement and Assessment Mobile Program (Project RAMP)

University of North Carolina, Chapel Hill

NCT04151498

COMPLETED NA 28 participants

Youth Ending the HIV Epidemic

University of California, San Francis

NCT05789875

COMPLETED Phase 1 26 participants

Relative Mitochondrial Toxicity of Tenofovir Alafenamide (TAF) vs. Tenofovir Disoproxil Fumarate (TDF)

University of California, Los Angeles

NCT03251144

COMPLETED 24 participants

Platelet Function on Abacavir and Tenofovir

University of California, Los Angeles

NCT03081572

COMPLETED NA 24 participants

The BRIDGES Project: Bridging Resources to Engage Women in Integrated HIV Care and Support Services

University of California, San Diego

NCT04295876

COMPLETED NA 21 participants

Interventions to Improve the HIV PrEP Cascade Among Methamphetamine Users

University of Washington

NCT03584282

COMPLETED NA 20 participants

Cognitive Behavioral Therapy to Treat Insomnia in Persons With HIV Infection

Indiana University

NCT03390114

COMPLETED NA 16 participants

Web-Based Cognitive Behavioral Stress Management for Latino Sexual Minority Men Living With HIV and Cancer

University of Miami

NCT03993054

COMPLETED Phase 1 13 participants

Study in Healthy Males to Measure Darunavir and Etravirine in Blood, Seminal Fluid, and Rectal Tissue

University of North Carolina, Chapel Hill

NCT00855088

Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 2
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the HIV/AIDS Trial Landscape

ClinicalTrials.gov lists 62 US studies indexed under HIV/AIDS, and 15 of those are currently open to recruitment — roughly 24% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for HIV/AIDS shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 8 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for HIV/AIDS is led by University of California, San Francis with 7 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 62 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for HIV/AIDS?

PlainTrial tracks 62 US clinical trials for HIV/AIDS, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for HIV/AIDS?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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