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HIV/AIDS clinical trials
Every US clinical trial registered for HIV/AIDS — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
62 US clinical trials · 15 currently recruiting
The research picture
HIV/AIDS has 62 registered US clinical trials, 15 of them open to new participants right now — about 24% of the total.
- 15
- recruiting participants now
- 24%
- of trials open to enrollment
- 1
- in Phase 3–4 (later-stage)
- 7
- top sponsor: University of California, San Francis
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Observational Pharmaco-Epidemiology Research & Analysis
Epividian
NCT03813862
MyPEEPS LITE Trial
Columbia University
NCT06741631
Improving the Organizational Social Context to Address Structural Racism and Discrimination
University of Pennsylvania
NCT06462807
MyPEEPS Mobile Plus: A Multi-Level HIV Prevention Intervention for Young MSM
Columbia University
NCT06741618
Community Health Workers And MHealth to ImProve Viral Suppression Plus (CHAMPS+)
Columbia University
NCT06472206
Project I Test: Implementing HIV Testing in Opioid Treatment Programs
Columbia University
NCT03135886
Women SHINE: Addressing Syndemics and HIV Among Women Through Tech-Based Peer Engagement
University of California, San Diego
NCT05509959
Optimizing Tobacco Use Treatment for PLWHA
University of Pennsylvania
NCT04176172
ADELANTE: A Randomized Controlled Trial to Improve Engagement in Care for Latinos With HIV
Massachusetts General Hospital
NCT06274632
A Mobile Gaming App to Improve Adherence to PrEP
Rhode Island Hospital
NCT05762705
Appalachian Partnership to Reduce Disparities (Aim 2)
Wake Forest University Health Sciences
NCT04378439
An Integrated Intervention Using a Pill Ingestible Sensor System
University of California, Los Angeles
NCT06480578
An mHealth Intervention to Improve Outcomes for Women With HIV/AIDS
University of Miami
NCT03738410
LinkPositively+ A Mobile Health App Delivered Intervention to Improve HIV Care Outcomes Among Black Women Affected by Mental Health and Violence
Guiding Right
NCT06458660
SCOPE Analytic Treatment Interruption Protocol
University of California, San Francis
NCT04359186
ResIlience-based Stigma REdUction Program ("Rise-up")
University of South Carolina
NCT05174936
Intervention for Virologic Suppression in Youth
University of California, San Francis
NCT05877729
Effects of Semaglutide in HIV-Associated Lipohypertrophy
Case Western Reserve University
NCT04019197
Impact of HIV-1 and Aging on Mucosal Vaccine Responses
VA Eastern Colorado Health Care System
NCT03729778
Leveraging mHealth to Enable and Adapt CHW Strategies to Improve TB/HIV Patient Outcomes in SA
Johns Hopkins University
NCT04298905
Robot-Assisted Rehabilitation After HIV-Associated Stroke: Botswana
University of Pennsylvania
NCT04488250
Combinatorial Therapy to Induce an HIV Remission
University of California, San Francis
NCT04357821
HIV Jail POC-AgAB Testings
Montefiore Medical Center
NCT04296331
Theory-based HIV Disclosure Intervention for Parents
University of South Carolina
NCT04051177
PositiveLinks: mHealth for DC Cohort
George Washington University
NCT04998019
Effectiveness of Peer Navigation and Contingency Management on Retention in HIV Care
University of California, Los Angeles
NCT02310893
Behavioral Intervention to Enhance HIV Test/Treat
University of Connecticut
NCT01752777
Integrating HIV and Hepatitis C Screening in an Urban Emergency Department
New York City Health and Hospitals Corporation
NCT03252483
Leveraging mHealth and Peers to Engage African- Americans and Latinxs in HIV Care (LEAN)
Johns Hopkins University
NCT03934437
COVID-19 in Patients With HIV
University of Missouri-Columbia
NCT04333953
Adolescent Master Protocol for Participants 18 Years of Age or Older - Lite
Harvard School of Public Health (HSPH)
NCT03279185
A Randomized Controlled Trial of an Antiretroviral Treatment Adherence Intervention for HIV+ African Americans
RAND
NCT03331978
A Nurse-led Intervention to Extend the HIV Treatment Cascade for Cardiovascular Disease Prevention
Case Western Reserve University
NCT03643705
Duo Partnership Adherence Commitment Therapy
University of California, San Francis
NCT02925949
MEMO-Medical Marijuana and Opioids Study
Albert Einstein College of Medicine
NCT03268551
ART-CHESS: A Mobile Health Application to Support People Living With HIV and Addiction
University of Wisconsin, Madison
NCT03873129
CASA: Care and Support Access in HIV Disease
University of Maryland
NCT02136680
Symptom Management Efficacy Study to Reduce Distal Neuropathic Pain
New York University
NCT03855111
Prevention and Risk: Treatment With a New Emphasis on Relationships
Hunter College of City University of New York
NCT03396367
Developing and Examining Evidenced-Based HIV Testing Messages
Virginia Commonwealth University
NCT03433053
Project RAP: Family-based HIV Prevention in the Juvenile Drug Court
University of California, San Francis
NCT01403298
iSTEP - an mHealth Physical Activity and Diet Intervention for Persons With HIV
University of California, San Diego
NCT03123731
Linking High-Risk Jail Detainees to HIV Pre-Exposure Prophylaxis: PrEP-LINK
University of Arkansas
NCT04064567
Transgender Youth and PrEP: PK, Safety, Uptake & Adherence - Intervention Development
Hektoen Institute for Medical Research
NCT04077138
Enhancing Sexual Safety: Couples' Communication and HIV Testing Among YMSM
Florida State University
NCT04289116
PlusCare: Mobile Platform to Increase Linkage to Care in Adolescents Living With HIV/AIDS
Dimagi
NCT03758066
Assessment of Cognitive Functioning as it Relates to Risk for Suicide in Veterans With HIV/AIDS
VA Eastern Colorado Health Care System
NCT01749007
Transgender Youth and PrEP: PK, Safety, Uptake & Adherence - PK Study
Hektoen Institute for Medical Research
NCT03652623
Development of a Couple-Based Mobile Health Intervention for Enhancing HIV Care Engagement Outcomes (N'Gage)
University of California, San Francis
NCT03100643
Body Compartment Pharmacokinetics of Anti-retroviral Agents That May be Considered for Future On-demand Peri-exposure HIV Prophylaxis Regimens
Emory University
NCT03976752
Trauma Informed Intervention to Support Engagement in HIV Care Among MSM (THRIVE+)
Massachusetts General Hospital
NCT05822206
Depression Intervention Among Gay and Bisexual Men Receiving Treatment for Methamphetamine Use
Friends Research Institute
NCT03864653
HIV+ Substance Users Released From Jail
University of Texas Southwestern Medical Center
NCT03834779
HIV Reengagement and Assessment Mobile Program (Project RAMP)
University of North Carolina, Chapel Hill
NCT04151498
Youth Ending the HIV Epidemic
University of California, San Francis
NCT05789875
Relative Mitochondrial Toxicity of Tenofovir Alafenamide (TAF) vs. Tenofovir Disoproxil Fumarate (TDF)
University of California, Los Angeles
NCT03251144
Platelet Function on Abacavir and Tenofovir
University of California, Los Angeles
NCT03081572
The BRIDGES Project: Bridging Resources to Engage Women in Integrated HIV Care and Support Services
University of California, San Diego
NCT04295876
Interventions to Improve the HIV PrEP Cascade Among Methamphetamine Users
University of Washington
NCT03584282
Cognitive Behavioral Therapy to Treat Insomnia in Persons With HIV Infection
Indiana University
NCT03390114
Web-Based Cognitive Behavioral Stress Management for Latino Sexual Minority Men Living With HIV and Cancer
University of Miami
NCT03993054
Study in Healthy Males to Measure Darunavir and Etravirine in Blood, Seminal Fluid, and Rectal Tissue
University of North Carolina, Chapel Hill
NCT00855088
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 6 |
| Phase 2 | 2 |
| Phase 3 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the HIV/AIDS Trial Landscape
ClinicalTrials.gov lists 62 US studies indexed under HIV/AIDS, and 15 of those are currently open to recruitment — roughly 24% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for HIV/AIDS shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 8 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for HIV/AIDS is led by University of California, San Francis with 7 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 62 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for HIV/AIDS?
PlainTrial tracks 62 US clinical trials for HIV/AIDS, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for HIV/AIDS?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.