Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Cognitive Decline: early-phase trial registry
36 of 62 indexed Cognitive Decline trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #228 of 28,707 conditions by registered trial count.
62 US clinical trials · 36 currently recruiting · #228 of 28,707 conditions by registered trial count
Cognitive Decline: 62 US clinical trials tracked, 36 recruiting.
Cognitive Decline is the subject of 62 registered US clinical trials on ClinicalTrials.gov, 36 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most active sponsor is C2N Diagnostics, running 2 of these trials.
Enrollment posture brief
Registry condition cognitive-decline
OPEN 36 | RECR 58% | LATE 2 | EARLY 8 | RANK #228 | SPON 2
Volume-matched condition peers
Nearest open-share peer: Infant Development (58% recruiting · 31 trials)
Cognitive Decline lists 36 open slots (58% of 62 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Cognitive Decline on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Cognitive Decline is recruiting above its size-band peers.
36 of 62 indexed trials (58.1%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Cognitive Decline trials is spread across many organizations.
C2N Diagnostics accounts for 2 of 62 trials (3.2%). 53 distinct sponsors appear on at least one study for this condition label.
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Typical Cognitive Decline enrolment sits around 150 participants.
Median target enrolment is 150 among the 62 trials that report a genuine target (sentinel values excluded). 19 of those (30.6%) plan for fewer than 100 participants.
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Cognitive Decline research is mostly interventional.
49 interventional and 13 observational studies make up this index (79% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
62 total, page 1 of 2
Primary Care Detection of Cognitive Impairment Leveraging Health & Consumer Technologies in Underserved Communities: The MyCog Trial
Northwestern University
NCT05607732
Preventing Cognitive Decline by Reducing BP Target Trial
University of Texas Southwestern Medical Center
NCT05106036
Enhancing Attention and Wellbeing Using Digital Therapeutics
University of California, San Francisco
NCT06397469
Computerized Tests of Cognitive Decline in Presymptomatic Alzheimer's Disease
Neurobehavioral Systems
NCT04800588
Alzheimer's Disease Treatment With Combination of 40Hz Light and Cognitive Therapy
Alzheimer's Light
NCT03657745
Older Breast Cancer Patients: Risk for Cognitive Decline
Georgetown University
NCT03451383
Biomarker Exploration in Aging, Cognition and Neurodegeneration
University of California, Irvine
NCT03860857
Attenuating DEPression With Internet CBT to Slow Cognitive Decline in Older ICU Survivors(ADEPT-ICU)
Indiana University
NCT06627894
Cognitive and Vascular Functioning Following TBI
Walter Reed National Military Medical Center
NCT06034509
Polyphenols and Cognitive Decline
University of California, Los Angeles
NCT06507254
Building a Platform for Precision Anesthesia in the Geriatric Surgical Patient
Stanford University
NCT03839784
Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging
Natalie Denburg
NCT03954899
Exercise Adherence and Cognitive Decline: Phase 2
University of Colorado, Boulder
NCT07127965
A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses
Arizona State University
NCT05877196
δ in Dementia Clinical Trials
The University of Texas Health Science Center at San Antonio
NCT05592678
The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Study
California Pacific Medical Center Research Institute
NCT05988385
mPATH for Low-income Older Adults
Johns Hopkins University
NCT05935241
Optimizing CNS DHA Delivery in Elderly Adults at Risk for Dementia
University of Cincinnati
NCT06933095
Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium
Massachusetts General Hospital
NCT06052397
Brain Health Virtual Reality Study
University of California, San Diego
NCT06124339
Study Evaluating the Quality and Effects of Lion's Mane Product on Cognitive Health
M2 Ingredients
NCT06870136
Effects of Sabroxy® Supplementation on Insulin Resistance and Cognitive Function in Adults With Mild Cognitive Impairment and Insulin Resistance
SF Research Institute
NCT07220694
MIND Foods and Aerobic Training in Black Adults With HTN
Indiana University
NCT06152614
Door-Through-Door Companion Rideshare Technology for Individuals With Alzheimer's Disease and Related Dementias (AD/ADRD)
Onward Health
NCT06850870
A Mechanistic Study to Investigate tDCS and Working Memory in MCI Patients
University of Florida
NCT05998031
A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors
University of Washington
NCT06411561
Cognitive Screening Made Easy for PCPs - Administrative Supplement
University of Texas at Austin
NCT06928298
Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer
UNC Lineberger Comprehensive Cancer Center
NCT06727773
Essential Fats For Enhancing Cognitive Thinking (EFFECT) Study
Ohio State University
NCT06223672
TMS for Cognitive Decline in Aging and Preclinical AD
Massachusetts General Hospital
NCT06956300
Cognitive Impairment in Colorectal Cancer Patients Receiving Cytotoxic Chemotherapy
Joseph McCollom
NCT05014399
MindWalk Intervention for Older South Asian Caregivers of People With Cognitive Disabilities (CD)
University of Illinois at Chicago
NCT06002919
Brain Research Assessing Impacts of Neurophysiological Processing Speed Training in Veterans
University of Alabama at Birmingham
NCT06217575
Glucose Variability and Cognition in Prediabetes
University of Maryland, Baltimore
NCT04201600
Exercise Adherence and Cognitive Decline
University of Colorado, Boulder
NCT06769022
Fortifying Healthy Behaviors, Optimizing Medical Therapies and Enhancing Cognitive Function in Older Adults-pilot Study
Washington University School of Medicine
NCT07000734
Implementation of Multifaceted Patient-Centered Treatment Strategies for Intensive Blood Pressure Control in Minimize Cognitive Decline
Tulane University
NCT04797403
Impact of a Novel Brain Longevity Supplement Containing the Postbiotic Urolithin A (Mitopure) on Cognitive Function and Related Health Outcomes
Amazentis
NCT07060898
ACHIEVE Brain Health Follow-Up Study
Johns Hopkins University
NCT05532657
BRINK (BRain In Kidney Disease) Memory Study 2.0
Anne Murray
NCT04975464
Cognitive Screening Made Easy for PCPs - R33 Phase
University of Texas at Austin
NCT06162026
Quality Improvement and Clinical Utility PrecivityAD2(TM) Clinician Survey
C2N Diagnostics
NCT06025877
Advancing Postmenopausal Preventive Therapy
University of Southern California
NCT04103476
Effect of Equol Supplementation on Arterial Stiffness and Cognition in Healthy Volunteers
Akira Sekikawa
NCT05741060
Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet in Stroke Patients Patients
Rush University Medical Center
NCT04337255
High-dose Vitamin D Supplements in Older Adults
University of California, Davis
NCT03613116
Tau Pet Imaging in the Aging Brain Cohort Dedicated to Diversity Study
University of Pennsylvania
NCT05393388
Dopaminergic Dysfunction in Late-Life Depression
Vanderbilt University Medical Center
NCT04469959
Multi-Center Study of Sensory Stimulation to Improve Brain Function
Cognito Therapeutics
NCT03556280
A Clinical Trial to Investigate the Efficacy of a Supplement to Improve and Maintain Cognitive Function and Memory
Scale Media
NCT06523218
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 7 |
| Phase 3 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Cognitive Decline records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Cognitive Decline trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Cognitive Decline page
62 registered trials, 36 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 36 Cognitive Decline trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- C2N Diagnostics sponsors the most Cognitive Decline trials on record, review their full trial history before evaluating a specific study. See C2N Diagnostics's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Cognitive Decline condition card totals 62 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.