Karyopharm Therapeutics

25 total trials 5 currently recruiting 9 completed

Karyopharm Therapeutics sponsors 25 registered US clinical trials on ClinicalTrials.gov, 5 of them currently recruiting, and 9 completed. 4 of these trials are in Phase 3-4 (later-stage) and 21 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Myelofibrosis, with 3 trials.

Trial Pipeline

25 total, page 1 of 1

RECRUITING Phase 2

A Study of Selinexor Monotherapy in Subjects With JAK Inhibitor-naïve Myelofibrosis and Moderate Thrombocytopenia

NCT05980806

RECRUITING Phase 3

Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma

NCT05611931

RECRUITING Phase 2

A Study of Rituximab-Gemcitabine-Dexamethasone-Platinum (R-GDP) With or Without Selinexor in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma

NCT04442022

RECRUITING Phase 1

Selinexor and Backbone Treatments of Multiple Myeloma Patients

NCT02343042

RECRUITING Phase 2

Selinexor (KPT-330) in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)

NCT02227251

ACTIVE NOT RECRUITING Phase 2

A Study to Evaluate Single Agent Selinexor Versus Physician's Choice in Participants With Previously Treated Myelofibrosis

NCT04562870

ACTIVE NOT RECRUITING Phase 3

Study of Selinexor in Combination With Ruxolitinib in Myelofibrosis

NCT04562389

ACTIVE NOT RECRUITING Phase 3

Maintenance with Selinexor/Placebo After Combination Chemotherapy in Participants with Endometrial Cancer [SIENDO]

NCT03555422

TERMINATED Phase 2

A Study to Evaluate the Safety and Efficacy of Selinexor With or Without Pembrolizumab Versus Standard of Care in Previously Treated Metastatic Colorectal Cancer With RAS Mutations

NCT04854434

TERMINATED Phase 2

Safety and Efficacy of Selinexor in Combination With Pembrolizumab in Recurrent Advanced Melanoma

NCT04768881

TERMINATED Phase 1

A Study of Selinexor in Combination With Standard of Care Therapy for Newly Diagnosed or Recurrent Glioblastoma

NCT04421378

COMPLETED Phase 2

Evaluation of Activity and Safety of Oral Selinexor in Participants With Severe COVID-19 Infection

NCT04349098

COMPLETED Phase 3

Bortezomib, Selinexor, and Dexamethasone in Patients With Multiple Myeloma

NCT03110562

TERMINATED Phase 1

PAK4 and NAMPT in Patients With Solid Malignancies or NHL (PANAMA)

NCT02702492

COMPLETED Phase 2

Selinexor in Advanced Liposarcoma

NCT02606461

COMPLETED Phase 1

Study of the Safety, Tolerability and Efficacy of KPT-8602 in Participants With Relapsed/Refractory Cancer Indications

NCT02649790

COMPLETED Phase 2

Selinexor Treatment of Refractory Myeloma

NCT02336815

TERMINATED Phase 2

Selinexor in Initial or Refractory and/or Relapsed Richter's Transformation

NCT02138786

TERMINATED Phase 2

Selinexor Treatment of Advanced Relapsed/Refractory Squamous Cell Carcinomas

NCT02213133

TERMINATED Phase 2

SHIP (Selinexor in Hormone Insensitive Prostate Cancer)

NCT02146833

TERMINATED Phase 2

Study Evaluating the Efficacy and Safety of Selinexor (KPT-330) in Participants With Recurrent Gliomas

NCT01986348

COMPLETED Phase 2

Selinexor (KPT-330) in Older Patients With Relapsed AML

NCT02088541

COMPLETED Phase 1

A Phase I Trial to Assess the Effects of Food and Formulation on PK of KPT-330 in Patients With Sarcoma

NCT01896505

COMPLETED Phase 1

Safety Study of the Selective Inhibitor of Nuclear Export (SINE) KPT-330 in Patients With Advanced Hematological Cancer

NCT01607892

COMPLETED Phase 1

Safety Study of KPT-330 (Selinexor) in Patients With Advanced or Metastatic Solid Tumor Cancer

NCT01607905

What the Pipeline for Karyopharm Therapeutics Shows

According to the ClinicalTrials.gov registry, Karyopharm Therapeutics is linked to 25 US clinical trials across every stage of research activity. Of those, 5 studies are currently recruiting, about 20% of the sponsor's indexed portfolio, and 9 are already marked complete, representing roughly 36% of the total.

The phase mix for Karyopharm Therapeutics reports 4 late-stage studies (Phase 3 and Phase 4 combined) and 21 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for Karyopharm Therapeutics is Myelofibrosis with 3 linked trials, and 6 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.