Karyopharm Therapeutics
Karyopharm Therapeutics sponsors 25 registered US clinical trials on ClinicalTrials.gov, 5 of them currently recruiting, and 9 completed. 4 of these trials are in Phase 3-4 (later-stage) and 21 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Myelofibrosis, with 3 trials.
Trial Pipeline
25 total, page 1 of 1
A Study of Selinexor Monotherapy in Subjects With JAK Inhibitor-naïve Myelofibrosis and Moderate Thrombocytopenia
NCT05980806
Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma
NCT05611931
A Study of Rituximab-Gemcitabine-Dexamethasone-Platinum (R-GDP) With or Without Selinexor in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma
NCT04442022
Selinexor and Backbone Treatments of Multiple Myeloma Patients
NCT02343042
Selinexor (KPT-330) in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
NCT02227251
A Study to Evaluate Single Agent Selinexor Versus Physician's Choice in Participants With Previously Treated Myelofibrosis
NCT04562870
Study of Selinexor in Combination With Ruxolitinib in Myelofibrosis
NCT04562389
Maintenance with Selinexor/Placebo After Combination Chemotherapy in Participants with Endometrial Cancer [SIENDO]
NCT03555422
A Study to Evaluate the Safety and Efficacy of Selinexor With or Without Pembrolizumab Versus Standard of Care in Previously Treated Metastatic Colorectal Cancer With RAS Mutations
NCT04854434
Safety and Efficacy of Selinexor in Combination With Pembrolizumab in Recurrent Advanced Melanoma
NCT04768881
A Study of Selinexor in Combination With Standard of Care Therapy for Newly Diagnosed or Recurrent Glioblastoma
NCT04421378
Evaluation of Activity and Safety of Oral Selinexor in Participants With Severe COVID-19 Infection
NCT04349098
Bortezomib, Selinexor, and Dexamethasone in Patients With Multiple Myeloma
NCT03110562
PAK4 and NAMPT in Patients With Solid Malignancies or NHL (PANAMA)
NCT02702492
Selinexor in Advanced Liposarcoma
NCT02606461
Study of the Safety, Tolerability and Efficacy of KPT-8602 in Participants With Relapsed/Refractory Cancer Indications
NCT02649790
Selinexor Treatment of Refractory Myeloma
NCT02336815
Selinexor in Initial or Refractory and/or Relapsed Richter's Transformation
NCT02138786
Selinexor Treatment of Advanced Relapsed/Refractory Squamous Cell Carcinomas
NCT02213133
SHIP (Selinexor in Hormone Insensitive Prostate Cancer)
NCT02146833
Study Evaluating the Efficacy and Safety of Selinexor (KPT-330) in Participants With Recurrent Gliomas
NCT01986348
Selinexor (KPT-330) in Older Patients With Relapsed AML
NCT02088541
A Phase I Trial to Assess the Effects of Food and Formulation on PK of KPT-330 in Patients With Sarcoma
NCT01896505
Safety Study of the Selective Inhibitor of Nuclear Export (SINE) KPT-330 in Patients With Advanced Hematological Cancer
NCT01607892
Safety Study of KPT-330 (Selinexor) in Patients With Advanced or Metastatic Solid Tumor Cancer
NCT01607905
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 14 |
| Phase 3 | 4 |
What the Pipeline for Karyopharm Therapeutics Shows
According to the ClinicalTrials.gov registry, Karyopharm Therapeutics is linked to 25 US clinical trials across every stage of research activity. Of those, 5 studies are currently recruiting, about 20% of the sponsor's indexed portfolio, and 9 are already marked complete, representing roughly 36% of the total.
The phase mix for Karyopharm Therapeutics reports 4 late-stage studies (Phase 3 and Phase 4 combined) and 21 earlier-phase studies (Phase 1 and Phase 2).
The top therapeutic focus area indexed for Karyopharm Therapeutics is Myelofibrosis with 3 linked trials, and 6 other condition areas appear in the top list above.
How to read these pipeline numbers
Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.