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ClinicalTrials.gov 29 recruiting now official registry

Myelofibrosis clinical trials

29 of 62 indexed Myelofibrosis trials are currently recruiting.

62 US clinical trials · 29 currently recruiting

Myelofibrosis is the subject of 62 registered US clinical trials on ClinicalTrials.gov, 29 of them currently open to new participants. 7 are in Phase 3-4 (later-stage) and 47 in Phase 1-2 (earlier-stage). The most active sponsor is Incyte Corporation, running 4 of these trials.

The research picture

Myelofibrosis has 62 registered US clinical trials, 29 of them open to new participants right now, about 47% of the total.

29
recruiting participants now
47%
of trials open to enrollment
7
in Phase 3–4 (later-stage)
4
top sponsor: Incyte Corporation
Phase 130Phase 217Phase 37

Active & Recent Trials

62 total, page 2 of 2

COMPLETED Phase 1 60 participants

TGR-1202 + Ruxolitinib PMF PPV-MF PET-MF MDS/MPN Polycythemia Vera Resistant to Hydroxyurea

Vanderbilt-Ingram Cancer Center

NCT02493530

COMPLETED Phase 1 59 participants

A Dose-escalation Study of the Safety and Tolerability of Orally Administered TG101348 in Patients With Myelofibrosis

TargeGen

NCT00631462

COMPLETED Phase 2 41 participants

Study of Ruxolitinib (INCB018424) Sustained Release Formulation in Myelofibrosis Patients

Incyte Corporation

NCT01340651

COMPLETED Phase 1 40 participants

Total Body Irradiation With Fludarabine Followed by Combined Umbilical Cord Blood (UCB) Transplants

Duke University

NCT00606437

COMPLETED NA 40 participants

Effects of Prebiotics on Gut Microbiome in Patients Undergoing HSCT

University of Virginia

NCT04629430

COMPLETED Phase 1 38 participants

Blinded Cross-Over Bioequivalence (BE) Trial of Luitpold Azacitidine vs Vidaza

American Regent

NCT01290302

COMPLETED Phase 2 34 participants

A Study of Gleevec in Patients With Idiopathic Myelofibrosis or Chronic Myelomonocytic Leukemia (CMML)

Dana-Farber Cancer Institute

NCT00136409

COMPLETED Phase 2 25 participants

Reduced Intensity Conditioning Transplant Using Haploidentical Donors

Northside Hospital

NCT02581007

COMPLETED Phase 2 22 participants

Safety and Efficacy of Obatoclax Mesylate (GX15-070MS) in the Treatment of Myelofibrosis With Myeloid Metaplasia

Gemin X

NCT00360035

COMPLETED Early Phase 1 21 participants

Pilot Trial of Arsenic + Cytarabine in Patients With Myelofibrosis

Weill Medical College of Cornell University

NCT00572065

COMPLETED Phase 2 16 participants

Reduced Intensity Allogeneic PBSCT to Treat Hematologic Malignancies and Hematopoietic Failure States

University of Arizona

NCT00997386

COMPLETED Phase 1 14 participants

Targeted Marrow Irradiation, Fludarabine Phosphate, and Busulfan Before Donor Progenitor Cell Transplant in Treating Patients With Hematologic Malignancies

Case Comprehensive Cancer Center

NCT02129582

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Phase Distribution

PhaseTrial count
Phase 1 30
Phase 2 17
Phase 3 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Myelofibrosis Trial Landscape

62 indexed Myelofibrosis studies · 29 recruiting (47%).

Phase mix: 7 late (III/IV) vs 47 early (I/II).

Top sponsor: Incyte Corporation (4 trials), 9 others listed. 12 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Myelofibrosis?

PlainTrial tracks 62 US clinical trials for Myelofibrosis, of which 29 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Myelofibrosis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.