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NCT04771572 · ClinicalTrials.gov registry record · Phase 1
Study of Oral Administration of LP-118 in Patients With Relapsed or Refractory CLL, SLL, MDS, MDS/MPN, AML, CMML-2, MPN-BP, ALL, MF, NHL, RT, MM or T-PLL.
A Phase 1 study of Multiple Myeloma and Acute Myeloid Leukemia, sponsored by Newave Pharmaceutical.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 100
- Enrollment target
- 8
- Study locations
NCT04771572: Recruiting Phase 1 study of Multiple Myeloma and Acute Myeloid Leukemia, sponsored by Newave Pharmaceutical.
NCT04771572 is a Phase 1 study of Multiple Myeloma and Acute Myeloid Leukemia that is actively recruiting participants, run by Newave Pharmaceutical. The registered enrollment target is 100 participants, below the 547-participant average among 438 other Multiple Myeloma trials with a reported enrollment target (82% lower). The trial reports 8 study locations across 6 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04771572, a Phase 1 study of Multiple Myeloma and Acute Myeloid Leukemia, is actively recruiting participants, sponsored by Newave Pharmaceutical.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 100 participants
- Enrollment target
- 8
- Study locations
Study Summary
This is a Phase 1, multi-center, open-label study with a dose-escalation phase (Phase 1a) and a cohort expansion phase (Phase 1b), to evaluate the safety, tolerability, and PK profile of LP-118 under a once daily oral dosing schedule in up to 100 subjects.
Primary Outcome
If 2 out of 6 subjects in an expanded cohort experience a DLT then this dose is considered the MTD.
Conditions Studied
Interventions
- DRUG LP-118
Study Locations (8)
Ohio
- Cincinnati Children's Hospital Medical Center - Cincinnati
- University of Cincinnati - Cincinnati
- The Ohio State University - Columbus
Illinois
- University of Chicago - Chicago
Massachusetts
- Dana Farber Cancer Institute - Boston
North Carolina
- University of North Carolina - Chapel Hill
Texas
- MD Anderson Cancer Center - Houston
Utah
- University of Utah - Salt Lake City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2021-08-23 |
| Est. Completion | 2025-10-01 |
| Phase | Phase 1 |
What NCT04771572 shows while recruiting
NCT04771572 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 547-participant average among 438 other Multiple Myeloma trials with a reported enrollment target (82% lower).
The record links to 10 conditions, with Multiple Myeloma appearing as the primary indexed condition, and to 1 intervention - of which LP-118 is the first listed.
NCT04771572 lists 8 locations in 6 states (Ohio, Illinois, Massachusetts).
Frequently Asked Questions
What is clinical trial NCT04771572 about?
NCT04771572 is a clinical study titled "Study of Oral Administration of LP-118 in Patients With Relapsed or Refractory CLL, SLL, MDS, MDS/MPN, AML, CMML-2, MPN-BP, ALL, MF, NHL, RT, MM or T-PLL.". This is a Phase 1, multi-center, open-label study with a dose-escalation phase (Phase 1a) and a cohort expansion phase (Phase 1b), to evaluate the safety, tolerability, and PK profile of LP-118 under a once daily oral dosing schedule in up to 100 subjects.
What is the current status of trial NCT04771572?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 100 participants. The study started on 2021-08-23. Estimated completion is 2025-10-01.
What conditions does trial NCT04771572 study?
This clinical trial studies the following conditions: Multiple Myeloma, Acute Myeloid Leukemia, Chronic Lymphocytic Leukemia, Non-Hodgkin Lymphoma, Myelofibrosis.
What interventions are being tested in trial NCT04771572?
The interventions under investigation include: LP-118 (DRUG).
Who is sponsoring clinical trial NCT04771572?
This trial is sponsored by Newave Pharmaceutical, which has 4 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04771572 being conducted?
This trial has 8 study locations across Illinois, Massachusetts, North Carolina, Ohio, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Multiple Myeloma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04771572's enrollment target sits among peer trials
100 165th of 438 higher than 262 of 438 other Multiple Myeloma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Multiple Myeloma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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