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RECRUITING Phase 2

Myeloablative Allo HSCT With Related or Unrelated Donor for Heme Disorders

NCT03314974 · View on ClinicalTrials.gov ↗

Study Summary

This is a Phase II study of allogeneic hematopoietic stem cell transplant (HCT) using a myeloablative preparative regimen (of either total body irradiation (TBI); or, fludarabine/busulfan for patients unable to receive further radiation). followed by a post-transplant graft-versus-host disease (GVHD) prophylaxis regimen of post-transplant cyclophosphamide (PTCy), tacrolimus (Tac), and mycophenolate mofetil (MMF).

Interventions

  • BIOLOGICAL HSCT with TBI Regimen
  • BIOLOGICAL HSCT with Non-TBI Regimen

Study Locations (1)

Minnesota

  • Masonic Cancer Center at University of Minnesota — Minneapolis

Trial Details

FieldValue
Enrollment Target 300 participants
Start Date 2018-03-30
Est. Completion 2027-06-10
Phase Phase 2

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03314974

The ClinicalTrials.gov registry entry for NCT03314974 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 300 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Masonic Cancer Center, University of Minnesota, which has 154 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 10 conditions, with Lymphoma appearing as the primary indexed condition, and to 2 interventions — of which HSCT with TBI Regimen is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03314974 reports 1 study location spanning 1 distinct geographic area — top geographies include Minnesota. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03314974 about?

NCT03314974 is a clinical study titled "Myeloablative Allo HSCT With Related or Unrelated Donor for Heme Disorders". This is a Phase II study of allogeneic hematopoietic stem cell transplant (HCT) using a myeloablative preparative regimen (of either total body irradiation (TBI); or, fludarabine/busulfan for patients unable to receive further radiation). followed by a post-transplant graft-versus-host disease (GVHD...

What is the current status of trial NCT03314974?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 300 participants. The study started on 2018-03-30. Estimated completion is 2027-06-10.

What conditions does trial NCT03314974 study?

This clinical trial studies the following conditions: Lymphoma, Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelofibrosis, Acute Leukemia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03314974?

The interventions under investigation include: HSCT with TBI Regimen (BIOLOGICAL), HSCT with Non-TBI Regimen (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03314974?

This trial is sponsored by Masonic Cancer Center, University of Minnesota, which has 154 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03314974 being conducted?

This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial