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Mood Disorders clinical trials
15 of 40 indexed Mood Disorders trials are currently recruiting.
40 US clinical trials · 15 currently recruiting
Mood Disorders is the subject of 40 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Mental Health (NIMH), running 8 of these trials.
The research picture
Mood Disorders has 40 registered US clinical trials, 15 of them open to new participants right now, about 38% of the total.
- 15
- recruiting participants now
- 38%
- of trials open to enrollment
- 3
- in Phase 3–4 (later-stage)
- 8
- top sponsor: National Institute of Mental Health (NIMH)
Active & Recent Trials
40 total, page 1 of 1
Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers
National Institute of Mental Health (NIMH)
NCT00024635
Clinical Study Evaluating Pharmacogenomics-informed Pharmacotherapy Versus Dosing as Usual in Psychiatric Disorders
Maastricht University Medical Center
NCT05656469
Resilience in Adolescent Development
University of Texas Southwestern Medical Center
NCT03458936
Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety Disorders
National Institute of Mental Health (NIMH)
NCT00397111
Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes
Colorado State University
NCT05543083
Neurostimulation Versus Therapy for Problems With Emotions
Duke University
NCT05712057
Clinical Validation of Samsung Smartwatch
Massachusetts General Hospital
NCT05767593
A Preventive Behavioral Intervention for Young Adults With Psychotic Experiences
Massachusetts General Hospital
NCT06929442
Mechanisms of Rumination Change in Adolescent Depression
Ohio State University
NCT03859297
Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness
Brigham and Women's Hospital
NCT06376734
Cold and Heat Investigation to Lower Levels of Depression
Barry Sandler
NCT06263738
RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty
University of Pittsburgh
NCT05658796
Brain, Emotions, and Mind-Wandering
University of Pittsburgh
NCT05345392
Evaluate the Effects of Long-term Use of Psychotropic Medications on Eye Movement Patterns With the Gaize Device
Gaize
NCT07389473
Suicide Specific Rumination in Veterans
VA Office of Research and Development
NCT06481033
Studying the Health of Asians to Advance Knowledge, Treatments, and Interventions for Depression
University of Texas Southwestern Medical Center
NCT06002204
Epidemiology of Sleep-Disordered Breathing in Adults
University of Wisconsin, Madison
NCT00005557
Reconnecting to Ourselves and Others in Virtual Meetings (ROOM)
Massachusetts General Hospital
NCT06360562
Unobtrusive Monitoring of Affective Symptoms and Cognition Using Keyboard Dynamics (UnMASCK)
University of Illinois at Chicago
NCT04358900
Individualized Functional Connectivity Targeting in aiTBS for Depression
Brigham and Women's Hospital
NCT05680727
Testing a Transdiagnostic TMS Treatment Target
Brigham and Women's Hospital
NCT06282146
Family Study of Affective and Anxiety Spectrum Disorders
National Institute of Mental Health (NIMH)
NCT00071786
Child & Adolescent Bipolar Disorder Brain Imaging and Treatment Study
National Institute of Mental Health (NIMH)
NCT00006177
Study of the Safety and Efficacy of Fixed-dose Brexpiprazole (OPC-34712) as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder With and Without Anxious Distress
Otsuka Pharmaceutical Development & Commercialization
NCT02196506
Can Genetics Predict Treatment Response to a Computerized Self-help Program for Depression?
University of Texas at Austin
NCT01818453
Analysis of Sleep Study Data to Assess Depressive Burden
Medibio Limited
NCT04232267
Relative Bioavailability of LY03010 Compared to Listed Drug
Luye Pharma Group
NCT04922593
Efficacy Evaluation of a Unified Transdiagnostic Treatment for Anxiety Disorders
Boston University Charles River Campus
NCT01243606
Effects of Drugs on Cerebral Blood Flow in Patients With Mood Disorders
National Institute of Mental Health (NIMH)
NCT00001478
Family-Focused Therapy for Youth With Early-Onset Bipolar or Psychotic Disorders
University of California, Los Angeles
NCT02097563
Multifaceted Depression and Cardiovascular Program
University of Southern California
NCT02069912
An Open-Label Trial Measuring Satisfaction And Convenience Of Two Formulations Of Lamotrigine In Subjects With A Mood Disorder
GlaxoSmithKline
NCT00579982
Family Promoting Positive Emotions Pilot Study
Vanderbilt University
NCT05223842
Mobile App for Mood in Pregnancy (Ginger iO)
University of Pennsylvania
NCT02761720
Identifying the Role of Oxytocin and Vasopressin in the Functioning of Neurocognitive Systems Involved in Mood Disorders
National Institute of Mental Health (NIMH)
NCT00325065
Rapid Antidepressant Effects of Ketamine in Major Depression
National Institute of Mental Health (NIMH)
NCT00088699
Reducing Suicide Risk in Adolescents and Young Adults Via a Psychobehavioral Intervention to Regularize Daily Rhythms
Yale University
NCT05317481
Study of the Hypothalmic-Pituitary-Adrenal (HPA) Axis and Its Role in Major Depression
National Institute of Mental Health (NIMH)
NCT00001479
Insulin Resistance in Patients With Major Depression
Stanford University
NCT01106313
Treatment With Quetiapine for Youth With Substance Use Disorders and Severe Mood Dysregulation
Boston Medical Center
NCT02845453
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 3 |
| Phase 3 | 2 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Mood Disorders Trial Landscape
40 indexed Mood Disorders studies · 15 recruiting (38%).
Phase mix: 3 late (III/IV) vs 6 early (I/II).
Top sponsor: National Institute of Mental Health (NIMH) (8 trials), 9 others listed. 40 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Mood Disorders?
PlainTrial tracks 40 US clinical trials for Mood Disorders, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Mood Disorders?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.