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Mood Disorders: early-phase trial registry
15 of 40 indexed Mood Disorders trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #368 of 28,707 conditions by registered trial count.
40 US clinical trials · 15 currently recruiting · #368 of 28,707 conditions by registered trial count
Mood Disorders: 40 US clinical trials tracked, 15 recruiting.
Mood Disorders is the subject of 40 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Mental Health (NIMH), running 8 of these trials.
Enrollment posture brief
Registry condition mood-disorders
OPEN 15 | RECR 38% | LATE 3 | EARLY 6 | RANK #368 | SPON 8
Volume-matched condition peers
Nearest open-share peer: Acute-graft-versus-host Disease (38% recruiting · 8 trials)
Mood Disorders lists 15 open slots (38% of 40 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Mood Disorders on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Mood Disorders is recruiting below its size-band peers.
15 of 40 indexed trials (37.5%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Mood Disorders research.
National Institute of Mental Health (NIMH) accounts for 8 of 40 trials (20%). 27 distinct sponsors appear on at least one study for this condition label.
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Typical Mood Disorders enrolment sits around 174 participants.
Median target enrolment is 174 among the 40 trials that report a genuine target (sentinel values excluded). 13 of those (32.5%) plan for fewer than 100 participants.
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Mood Disorders splits between interventional and observational designs.
24 interventional and 16 observational studies make up this index (60% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
40 total, page 1 of 1
Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers
National Institute of Mental Health (NIMH)
NCT00024635
Clinical Study Evaluating Pharmacogenomics-informed Pharmacotherapy Versus Dosing as Usual in Psychiatric Disorders
Maastricht University Medical Center
NCT05656469
Resilience in Adolescent Development
University of Texas Southwestern Medical Center
NCT03458936
Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety Disorders
National Institute of Mental Health (NIMH)
NCT00397111
Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes
Colorado State University
NCT05543083
Neurostimulation Versus Therapy for Problems With Emotions
Duke University
NCT05712057
Clinical Validation of Samsung Smartwatch
Massachusetts General Hospital
NCT05767593
A Preventive Behavioral Intervention for Young Adults With Psychotic Experiences
Massachusetts General Hospital
NCT06929442
Mechanisms of Rumination Change in Adolescent Depression
Ohio State University
NCT03859297
Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness
Brigham and Women's Hospital
NCT06376734
Cold and Heat Investigation to Lower Levels of Depression
Barry Sandler
NCT06263738
RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty
University of Pittsburgh
NCT05658796
Brain, Emotions, and Mind-Wandering
University of Pittsburgh
NCT05345392
Evaluate the Effects of Long-term Use of Psychotropic Medications on Eye Movement Patterns With the Gaize Device
Gaize
NCT07389473
Suicide Specific Rumination in Veterans
VA Office of Research and Development
NCT06481033
Studying the Health of Asians to Advance Knowledge, Treatments, and Interventions for Depression
University of Texas Southwestern Medical Center
NCT06002204
Epidemiology of Sleep-Disordered Breathing in Adults
University of Wisconsin, Madison
NCT00005557
Reconnecting to Ourselves and Others in Virtual Meetings (ROOM)
Massachusetts General Hospital
NCT06360562
Unobtrusive Monitoring of Affective Symptoms and Cognition Using Keyboard Dynamics (UnMASCK)
University of Illinois at Chicago
NCT04358900
Individualized Functional Connectivity Targeting in aiTBS for Depression
Brigham and Women's Hospital
NCT05680727
Testing a Transdiagnostic TMS Treatment Target
Brigham and Women's Hospital
NCT06282146
Family Study of Affective and Anxiety Spectrum Disorders
National Institute of Mental Health (NIMH)
NCT00071786
Child & Adolescent Bipolar Disorder Brain Imaging and Treatment Study
National Institute of Mental Health (NIMH)
NCT00006177
Study of the Safety and Efficacy of Fixed-dose Brexpiprazole (OPC-34712) as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder With and Without Anxious Distress
Otsuka Pharmaceutical Development & Commercialization
NCT02196506
Can Genetics Predict Treatment Response to a Computerized Self-help Program for Depression?
University of Texas at Austin
NCT01818453
Analysis of Sleep Study Data to Assess Depressive Burden
Medibio Limited
NCT04232267
Relative Bioavailability of LY03010 Compared to Listed Drug
Luye Pharma Group
NCT04922593
Efficacy Evaluation of a Unified Transdiagnostic Treatment for Anxiety Disorders
Boston University Charles River Campus
NCT01243606
Effects of Drugs on Cerebral Blood Flow in Patients With Mood Disorders
National Institute of Mental Health (NIMH)
NCT00001478
Family-Focused Therapy for Youth With Early-Onset Bipolar or Psychotic Disorders
University of California, Los Angeles
NCT02097563
Multifaceted Depression and Cardiovascular Program
University of Southern California
NCT02069912
An Open-Label Trial Measuring Satisfaction And Convenience Of Two Formulations Of Lamotrigine In Subjects With A Mood Disorder
GlaxoSmithKline
NCT00579982
Family Promoting Positive Emotions Pilot Study
Vanderbilt University
NCT05223842
Mobile App for Mood in Pregnancy (Ginger iO)
University of Pennsylvania
NCT02761720
Identifying the Role of Oxytocin and Vasopressin in the Functioning of Neurocognitive Systems Involved in Mood Disorders
National Institute of Mental Health (NIMH)
NCT00325065
Rapid Antidepressant Effects of Ketamine in Major Depression
National Institute of Mental Health (NIMH)
NCT00088699
Reducing Suicide Risk in Adolescents and Young Adults Via a Psychobehavioral Intervention to Regularize Daily Rhythms
Yale University
NCT05317481
Study of the Hypothalmic-Pituitary-Adrenal (HPA) Axis and Its Role in Major Depression
National Institute of Mental Health (NIMH)
NCT00001479
Insulin Resistance in Patients With Major Depression
Stanford University
NCT01106313
Treatment With Quetiapine for Youth With Substance Use Disorders and Severe Mood Dysregulation
Boston Medical Center
NCT02845453
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 3 |
| Phase 3 | 2 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Mood Disorders records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Mood Disorders trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Mood Disorders page
40 registered trials, 15 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 15 Mood Disorders trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- National Institute of Mental Health (NIMH) sponsors the most Mood Disorders trials on record, review their full trial history before evaluating a specific study. See National Institute of Mental Health (NIMH)'s trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Mood Disorders condition card totals 40 registered trials; most-linked intervention transcranial magnetic stimulation; top US site state Maryland. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.