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ClinicalTrials.gov 5 recruiting now full pipeline

Heart Failure, Congestive: full-pipeline trial registry

5 of 40 indexed Heart Failure, Congestive trials are currently recruiting.

Corpus placement: #368 of 28,707 conditions by registered trial count.

40 US clinical trials · 5 currently recruiting · #368 of 28,707 conditions by registered trial count

Heart Failure, Congestive: 40 US clinical trials tracked, 5 recruiting.

Heart Failure, Congestive is the subject of 40 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 10 in Phase 1-2 (earlier-stage). The most active sponsor is US Department of Veterans Affairs, running 6 of these trials.

Enrollment posture brief

Registry condition heart-failure-congestive

OPEN 5 | RECR 13% | LATE 11 | EARLY 10 | RANK #368 | SPON 6

Nearest open-share peer: Acute Respiratory Infection (13% recruiting · 8 trials)

Anatomic Stage IIIA Breast C35%Human Papilloma Virus35%Human Immunodeficiency Virus30%Heart Failure, Congestiv (th…13%Cocaine Dependence7.5%
Open-enrollment share among volume-matched conditions near Heart Failure, Congestive

Heart Failure, Congestive lists 5 open slots (13% of 40 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Heart Failure, Congestive on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Heart Failure, Congestive is recruiting below its size-band peers.

    5 of 40 indexed trials (12.5%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Heart Failure, Congestive research.

    US Department of Veterans Affairs accounts for 6 of 40 trials (15%). 30 distinct sponsors appear on at least one study for this condition label.

  3. Typical Heart Failure, Congestive enrolment sits around 195 participants.

    Median target enrolment is 195 among the 40 trials that report a genuine target (sentinel values excluded). 16 of those (40%) plan for fewer than 100 participants.

  4. Heart Failure, Congestive research is mostly interventional.

    33 interventional and 7 observational studies make up this index (82.5% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 15Phase 25Phase 36Phase 45

Open and recent trials

40 total, page 1 of 1

RECRUITING 1,500 participants

Prospective Observational Study of the ICD in Sudden Cardiac Death Prevention

Johns Hopkins University

NCT00733590

RECRUITING 500 participants

Magnetic Resonance Spectroscopy Studies of Cardiac Muscle Metabolism

Johns Hopkins University

NCT00181259

RECRUITING NA 320 participants

Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure

Procyrion

NCT05677100

RECRUITING Phase 4 80 participants

Diuretics vs. Afterload Reduction for Treatment of HeartLogic Alerts

Heart Center Research

NCT06218199

RECRUITING NA 50 participants

The ROle of Compression StocKings in Heart Failure Patients

University of Maryland, Baltimore

NCT06350695

ACTIVE NOT RECRUITING 5,888 participants

Cardiovascular Health Study (CHS)

National Heart, Lung, and Blood Institute (NHLBI)

NCT00005133

ACTIVE NOT RECRUITING 196 participants

HEARTBiT: Multi-Marker Blood Test for Acute Cardiac Transplant Rejection

University of British Columbia

NCT03575910

ACTIVE NOT RECRUITING 30 participants

Comparison of Noninvasive vs. Invasive Hemodynamic Measurements

Nihon Kohden

NCT06689215

ACTIVE NOT RECRUITING Phase 1 17 participants

AB-1002 in Patients With Class III Heart Failure

AskBio

NCT04179643

COMPLETED NA 2,512 participants

Project to Improve Communication About Serious Illness--Hospital Study: Pragmatic Trial (Trial 1)

University of Washington

NCT04281784

COMPLETED NA 2,487 participants

My Recordable On-Demand Audio Discharge Instructions

The Cleveland Clinic

NCT02901314

COMPLETED NA 2,358 participants

Hemodynamic-GUIDEd Management of Heart Failure

Abbott Medical Devices

NCT03387813

COMPLETED Phase 3 2,201 participants

Occluded Artery Trial (OAT)

NYU Langone Health

NCT00004562

COMPLETED Phase 3 2,136 participants

Comparison of Surgical and Medical Treatment for Congestive Heart Failure and Coronary Artery Disease

Duke University

NCT00023595

COMPLETED Phase 2 1,161 participants

Efficacy and Safety of Relaxin for the Treatment of Acute Heart Failure

Corthera, Inc.(formerly BAS Medical, Inc.), a member of the Novartis group of companies

NCT00520806

COMPLETED Phase 3 911 participants

IMMEDIATE Trial - Out of Hospital Administration of Glucose, Insulin and Potassium.

Tufts Medical Center

NCT00091507

COMPLETED 654 participants

Help Veterans Experience Less Pain Study (HELP-Vets)

US Department of Veterans Affairs

NCT00230932

COMPLETED NA 550 participants

Multidisciplinary Inpatient Palliative Care Intervention

Kaiser Permanente

NCT00325611

COMPLETED NA 438 participants

Telephone Intervention in Heart Failure Patients

US Department of Veterans Affairs

NCT00057057

COMPLETED NA 372 participants

Enhancing Caregiver Support for Heart Failure Patients: the CarePartner Study

US Department of Veterans Affairs

NCT00555360

COMPLETED Phase 3 300 participants

Reversal of Ventricular Remodeling With Toprol-XL

AstraZeneca

NCT00038077

COMPLETED Phase 4 250 participants

The Purpose of This Study is to Determine if Eplerenone is Effective in Treatment of Mild to Moderate Heart Failure

Pfizer's Upjohn has merged with Mylan to form Viatris

NCT00082589

COMPLETED NA 200 participants

Thoratec HeartMate II Left Ventricular Assist System (LVAS) for Destination Therapy

Abbott Medical Devices

NCT00121485

COMPLETED NA 195 participants

Insomnia Self-Management in Heart Failure

Yale University

NCT02660385

COMPLETED Phase 2 160 participants

Exercise After an ICD

University of Washington

NCT00522340

COMPLETED Phase 2 140 participants

Heart Pressure Assessment Study With Tolvaptan to Treat Congestive Heart Failure

Otsuka Pharmaceutical Development & Commercialization

NCT00132886

COMPLETED NA 114 participants

Collaborative Care for Heart Failure Patients With the Metabolic Syndrome

Baylor College of Medicine

NCT00293852

COMPLETED Phase 4 100 participants

Effects of Carvedilol on Health Outcomes in Heart Failure

Denver Health and Hospital Authority

NCT00381030

COMPLETED Phase 4 84 participants

Exercise Effect on Aerobic Capacity and QOL in Heart Failure

US Department of Veterans Affairs

NCT00013221

COMPLETED Phase 2 82 participants

A Multi-center, Placebo-controlled Study to Evaluate the Safety of GSK716155 and Its Effects on Myocardial Metabolism, Myocardial Function, and Exercise Capacity in Patients With NYHA Class II/III Congestive Heart Failure

GlaxoSmithKline

NCT01357850

COMPLETED Phase 3 80 participants

PIE II: Pharmacological Intervention in the Elderly II

Wake Forest University

NCT00123955

COMPLETED Phase 2 52 participants

Dose Escalation Study of KW-3902 on Diuresis in Subjects With Congestive Heart Failure (CHF).

NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

NCT00159627

COMPLETED Early Phase 1 40 participants

A Family Intervention for Improving Self-Care of Patients With Heart Failure

US Department of Veterans Affairs

NCT00645489

COMPLETED Phase 3 40 participants

Biventricular Pacing In Patients With Left Ventricular Dysfunction After Cardiovascular Surgery

Corewell Health East

NCT00321295

COMPLETED 30 participants

Registry of Patients With CardioMEMS

University of Pennsylvania

NCT02729922

COMPLETED Phase 4 27 participants

Statin Therapy in Heart Failure: Potential Mechanisms of Benefit

University of California, Los Angeles

NCT00233480

COMPLETED Early Phase 1 26 participants

Hemodynamic Response to Exercise in HFpEF Patients After Upregulation of SERCA2a

Benjamin Levine

NCT02772068

COMPLETED Phase 1 23 participants

Transforming Psychotherapy for Chronically Ill Patients

US Department of Veterans Affairs

NCT00520429

COMPLETED NA 13 participants

Effect of Chronic Changes in Heart Rate on Congestive Heart Failure

University of Maryland, Baltimore

NCT00389649

COMPLETED Early Phase 1 5 participants

Nicotinamide Riboside in LVAD Recipients

University of Washington

NCT03727646

Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 5
Phase 3 6
Phase 4 5

Named interventions

Most-linked intervention names on Heart Failure, Congestive records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Placebo Drug
5 trials
Atrial synchronous bi-ventricular pacing Device
1 trials
GSK716155 Drug
1 trials
Self-Management Education for Heart Failure Behavioral
1 trials
Multidisciplinary palliative care team met with patient Behavioral
1 trials
Telephone Care Behavioral
1 trials
Cardiomems Device
1 trials
HITCM only Behavioral
1 trials

US sites by state

Facility locations filed on Heart Failure, Congestive trials. A trial with sites in several states counts in each.

California 11 trials
Maryland 8 trials
Michigan 7 trials
Georgia 7 trials
Pennsylvania 6 trials
Illinois 6 trials
Florida 6 trials
Washington 5 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Heart Failure, Congestive page

40 registered trials, 5 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Heart Failure, Congestive condition card totals 40 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.