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2026 data Public-data reference. official source

Heart Failure, Congestive

Open-data reference.

34 US clinical trials · 4 currently recruiting

Active & Recent Trials

RECRUITING 1,500 participants

Prospective Observational Study of the ICD in Sudden Cardiac Death Prevention

Johns Hopkins University

NCT00733590

RECRUITING 500 participants

Magnetic Resonance Spectroscopy Studies of Cardiac Muscle Metabolism

Johns Hopkins University

NCT00181259

RECRUITING NA 320 participants

Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure

Procyrion

NCT05677100

RECRUITING Phase 4 80 participants

Diuretics vs. Afterload Reduction for Treatment of HeartLogic Alerts

Heart Center Research

NCT06218199

ACTIVE NOT RECRUITING 5,888 participants

Cardiovascular Health Study (CHS)

National Heart, Lung, and Blood Institute (NHLBI)

NCT00005133

ACTIVE NOT RECRUITING 30 participants

Comparison of Noninvasive vs. Invasive Hemodynamic Measurements

Nihon Kohden

NCT06689215

COMPLETED NA 2,487 participants

My Recordable On-Demand Audio Discharge Instructions

The Cleveland Clinic

NCT02901314

COMPLETED Phase 3 2,201 participants

Occluded Artery Trial (OAT)

NYU Langone Health

NCT00004562

COMPLETED Phase 3 2,136 participants

Comparison of Surgical and Medical Treatment for Congestive Heart Failure and Coronary Artery Disease

Duke University

NCT00023595

COMPLETED Phase 2 1,161 participants

Efficacy and Safety of Relaxin for the Treatment of Acute Heart Failure

Corthera, Inc.(formerly BAS Medical, Inc.), a member of the Novartis group of companies

NCT00520806

COMPLETED Phase 3 911 participants

IMMEDIATE Trial - Out of Hospital Administration of Glucose, Insulin and Potassium.

Tufts Medical Center

NCT00091507

COMPLETED 654 participants

Help Veterans Experience Less Pain Study (HELP-Vets)

US Department of Veterans Affairs

NCT00230932

COMPLETED NA 550 participants

Multidisciplinary Inpatient Palliative Care Intervention

Kaiser Permanente

NCT00325611

COMPLETED NA 438 participants

Telephone Intervention in Heart Failure Patients

US Department of Veterans Affairs

NCT00057057

COMPLETED NA 372 participants

Enhancing Caregiver Support for Heart Failure Patients: the CarePartner Study

US Department of Veterans Affairs

NCT00555360

COMPLETED Phase 3 300 participants

Reversal of Ventricular Remodeling With Toprol-XL

AstraZeneca

NCT00038077

COMPLETED Phase 4 250 participants

The Purpose of This Study is to Determine if Eplerenone is Effective in Treatment of Mild to Moderate Heart Failure

Pfizer's Upjohn has merged with Mylan to form Viatris

NCT00082589

COMPLETED NA 200 participants

Thoratec HeartMate II Left Ventricular Assist System (LVAS) for Destination Therapy

Abbott Medical Devices

NCT00121485

COMPLETED NA 195 participants

Insomnia Self-Management in Heart Failure

Yale University

NCT02660385

COMPLETED Phase 2 160 participants

Exercise After an ICD

University of Washington

NCT00522340

COMPLETED Phase 2 140 participants

Heart Pressure Assessment Study With Tolvaptan to Treat Congestive Heart Failure

Otsuka Pharmaceutical Development & Commercialization

NCT00132886

COMPLETED NA 114 participants

Collaborative Care for Heart Failure Patients With the Metabolic Syndrome

Baylor College of Medicine

NCT00293852

COMPLETED Phase 4 100 participants

Effects of Carvedilol on Health Outcomes in Heart Failure

Denver Health and Hospital Authority

NCT00381030

COMPLETED Phase 4 84 participants

Exercise Effect on Aerobic Capacity and QOL in Heart Failure

US Department of Veterans Affairs

NCT00013221

COMPLETED Phase 2 82 participants

A Multi-center, Placebo-controlled Study to Evaluate the Safety of GSK716155 and Its Effects on Myocardial Metabolism, Myocardial Function, and Exercise Capacity in Patients With NYHA Class II/III Congestive Heart Failure

GlaxoSmithKline

NCT01357850

COMPLETED Phase 3 80 participants

PIE II: Pharmacological Intervention in the Elderly II

Wake Forest University

NCT00123955

COMPLETED Phase 2 52 participants

Dose Escalation Study of KW-3902 on Diuresis in Subjects With Congestive Heart Failure (CHF).

NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

NCT00159627

COMPLETED Early Phase 1 40 participants

A Family Intervention for Improving Self-Care of Patients With Heart Failure

US Department of Veterans Affairs

NCT00645489

COMPLETED Phase 3 40 participants

Biventricular Pacing In Patients With Left Ventricular Dysfunction After Cardiovascular Surgery

Corewell Health East

NCT00321295

COMPLETED 30 participants

Registry of Patients With CardioMEMS

University of Pennsylvania

NCT02729922

COMPLETED Phase 4 27 participants

Statin Therapy in Heart Failure: Potential Mechanisms of Benefit

University of California, Los Angeles

NCT00233480

COMPLETED Early Phase 1 26 participants

Hemodynamic Response to Exercise in HFpEF Patients After Upregulation of SERCA2a

Benjamin Levine

NCT02772068

COMPLETED Phase 1 23 participants

Transforming Psychotherapy for Chronically Ill Patients

US Department of Veterans Affairs

NCT00520429

COMPLETED NA 13 participants

Effect of Chronic Changes in Heart Rate on Congestive Heart Failure

University of Maryland, Baltimore

NCT00389649

Phase Distribution

PhaseTrial count
Early Phase 1 3
Phase 2 5
Phase 3 6
Phase 4 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Heart Failure, Congestive Trial Landscape

ClinicalTrials.gov lists 34 US studies indexed under Heart Failure, Congestive, and 4 of those are currently open to recruitment — roughly 12% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Heart Failure, Congestive shows 11 late-stage studies (Phase 3 and Phase 4 combined) alongside 8 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Heart Failure, Congestive is led by US Department of Veterans Affairs with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 34 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Heart Failure, Congestive?

PlainTrial tracks 34 US clinical trials for Heart Failure, Congestive, of which 4 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Heart Failure, Congestive?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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