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NCT05345392 · ClinicalTrials.gov registry record · NA
Brain, Emotions, and Mind-Wandering
A NA study of Mood Disorders, sponsored by University of Pittsburgh.
- Recruiting
- Registry status
- NA
- Development phase
- 140
- Enrollment target
- 1
- Study location
NCT05345392: Recruiting NA study of Mood Disorders, sponsored by University of Pittsburgh.
NCT05345392 is a NA study of Mood Disorders that is actively recruiting participants, run by University of Pittsburgh. The registered enrollment target is 140 participants, below the 934-participant average among 39 other Mood Disorders trials with a reported enrollment target (85% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05345392, a NA study of Mood Disorders, is actively recruiting participants, sponsored by University of Pittsburgh.
- RECRUITING
- Registry status
- NA
- Development phase
- 140 participants
- Enrollment target
- 1
- Study location
Study Summary
Mood lability is an important transdiagnostic problem that is associated with poor psychosocial function and suicidal thoughts, and is a predictor of mood disorder onset, especially in youth at familial risk. Thus, particularly in youth with a family history of mood disorder, an intervention to target mood lability during a key period of development could improve outcomes. This study will allow us to test neurobehavioral mechanisms of a mindfulness-based intervention to target mood lability in early adolescents at high risk for developing mood disorders. Through this randomized controlled trial, the investigators will better understand how and for whom mindfulness interventions work, which will lead to more targeted interventions to improve emotion regulation during this key developmental period.
Primary Outcome
During each visit, the investigators will collect 10 minutes of resting-state data (eyes open; 2 runs, 5 minutes each), using Framewise Integrated Real-time MRI Monitoring (FIRMM) to ensure high quality. Following preprocessing, the investigators will assess resting-state functional connectivity between the posterior cingulate cortex (PCC; 0,-62,24; 4mm radius) and the frontoparietal control network (FPCN). The investigators will use mixed models to assess changes over time in the MBI vs. HWI gr
Conditions Studied
Interventions
- BEHAVIORAL Mindfulness-Based Intervention (MBI)
- BEHAVIORAL Health and Wellness Intervention (HWI)
Study Locations (1)
Pennsylvania
- Western Psychiatric Hospital - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 140 participants |
| Start Date | 2022-09-23 |
| Est. Completion | 2027-02-28 |
| Phase | NA |
What NCT05345392 shows while recruiting
NCT05345392 is an interventional study that assigns participants to a tested intervention. The registered 140 participants enrollment target is mid-sized for trials with a published cap, below the 934-participant average among 39 other Mood Disorders trials with a reported enrollment target (85% lower).
The record links to 1 condition, with Mood Disorders appearing as the primary indexed condition, and to 2 interventions - of which Mindfulness-Based Intervention (MBI) is the first listed.
NCT05345392 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT05345392 about?
NCT05345392 is a clinical study titled "Brain, Emotions, and Mind-Wandering". Mood lability is an important transdiagnostic problem that is associated with poor psychosocial function and suicidal thoughts, and is a predictor of mood disorder onset, especially in youth at familial risk. Thus, particularly in youth with a family history of mood disorder, an intervention to targ...
What is the current status of trial NCT05345392?
This trial is currently recruiting. It is a NA study. The enrollment target is 140 participants. The study started on 2022-09-23. Estimated completion is 2027-02-28.
What conditions does trial NCT05345392 study?
This clinical trial studies the following conditions: Mood Disorders.
What interventions are being tested in trial NCT05345392?
The interventions under investigation include: Mindfulness-Based Intervention (MBI) (BEHAVIORAL), Health and Wellness Intervention (HWI) (BEHAVIORAL).
Who is sponsoring clinical trial NCT05345392?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05345392 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Mood Disorders
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05345392's enrollment target sits among peer trials
140 24th of 39 higher than 16 of 39 other Mood Disorders trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Mood Disorders trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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