Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Cocaine Dependence: early-phase trial registry
3 of 40 indexed Cocaine Dependence trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #368 of 28,707 conditions by registered trial count.
40 US clinical trials · 3 currently recruiting · #368 of 28,707 conditions by registered trial count
Cocaine Dependence: 40 US clinical trials tracked, 3 recruiting.
Cocaine Dependence is the subject of 40 registered US clinical trials on ClinicalTrials.gov, 3 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 27 in Phase 1-2 (earlier-stage). The most active sponsor is Yale University, running 6 of these trials.
Enrollment posture brief
Registry condition cocaine-dependence
OPEN 3 | RECR 8% | LATE 0 | EARLY 27 | RANK #368 | SPON 6
Volume-matched condition peers
Nearest open-share peer: Sinusitis (8% recruiting · 13 trials)
Cocaine Dependence lists 3 open slots (8% of 40 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Cocaine Dependence on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Cocaine Dependence is recruiting below its size-band peers.
3 of 40 indexed trials (7.5%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Cocaine Dependence research.
Yale University accounts for 6 of 40 trials (15%). 24 distinct sponsors appear on at least one study for this condition label.
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Typical Cocaine Dependence enrolment sits around 106 participants.
Median target enrolment is 106 among the 39 trials that report a genuine target (sentinel values excluded). 19 of those (48.7%) plan for fewer than 100 participants.
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Cocaine Dependence research is mostly interventional.
37 interventional and 3 observational studies make up this index (92.5% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
40 total, page 1 of 1
Substance Abuse Pre-Treatment Screening Study
The University of Texas Health Science Center, Houston
NCT00439049
Safety Study of a Disrupted Adenovirus (Ad) Serotype Cocaine Vaccine for Cocaine-dependent Individuals
Weill Medical College of Cornell University
NCT02455479
Transcranial Direct Current Stimulation (tDCS) for Treatment of Cocaine Use Disorder
Icahn School of Medicine at Mount Sinai
NCT07318480
Clavulanic Acid for the Treatment of Cocaine Use Disorder
Temple University
NCT05562349
Effectiveness of Extended Treatments for Drug Dependence
University of Pennsylvania
NCT00685659
Clinical Trial of Topiramate for Cocaine Addiction
Johns Hopkins University
NCT00685178
Vouchers vs. Prizes for Cocaine-Dependent Methadone Patients - 2
UConn Health
NCT00249535
Vigabatrin for the Treatment of Cocaine Dependency
Catalyst Pharmaceuticals
NCT01281202
Vigabatrin for Treatment of Cocaine Dependence
Catalyst Pharmaceuticals
NCT00611130
Topiramate for Alcohol and Cocaine Dependence
Kyle Kampman
NCT00167245
Multicenter Trial of Combined Pharmacotherapy to Treat Cocaine Dependence
New York State Psychiatric Institute
NCT01811940
Long Term Maintenance of Drug Abstinence
Treatment Research Institute
NCT00842517
Valproate Efficacy in Cocaine-Bipolar Comorbidity
University of Miami
NCT00240110
Effectiveness of Enhanced Treatments for Drug Dependence
University of Pennsylvania
NCT01153477
Behavioral Treatment for Cocaine Dependent Women
Yale University
NCT00914381
Study of Adderall-XR for the Treatment of Adult Attention Deficit Hyperactivity Disorder and Cocaine Dependence
New York State Psychiatric Institute
NCT00553319
Risk Perception in Drug-Dependent Adults With and Without Schizophrenia
National Institute on Drug Abuse (NIDA)
NCT01031563
Disulfiram for Cocaine Abuse
University of Arkansas
NCT00395850
Treatment of Adult Attention Deficit Hyperactivity Disorder (ADHD) in Methadone Patients - 1
New York State Psychiatric Institute
NCT00061087
Citalopram for Cocaine Dependence
Joy Schmitz
NCT01535573
Cocaine Withdrawal and Pharmacotherapy Response
Yale University
NCT00566969
Combined Treatment for Cocaine-Alcohol Dependence - 1
The University of Texas Health Science Center, Houston
NCT00218569
Rivastigmine and Huperzine A as Treatments for Cocaine Dependence
Baylor College of Medicine
NCT01030692
Sex Differences in Progesterone Effects on Responses to Stress and Drug Cues
Yale University
NCT00585520
Complementary Combination Therapy for Cocaine Dependence
Baylor College of Medicine
NCT02538744
A Placebo-Controlled Study of a Combination of Metyrapone and Oxazepam in Cocaine Addiction
Embera NeuroTherapeutics
NCT00567814
Modafinil, Sleep, and Cognition in Cocaine Dependence
Yale University
NCT00582491
Imaging Synaptic Density in Cocaine and Opiate Addiction In Vivo Using 11UCB-J PET
Yale University
NCT03527485
Neurobehavioral Measurement of Substance Users in Outpatient Treatment Setting
Hunter Holmes Mcguire Veteran Affairs Medical Center
NCT03662529
Carvedilol for Psychostimulant Dependence
University of Arkansas
NCT01171183
PHASE IIA: Trial of a Novel Ondansetron Formulation (OND-PR002) and Immediate-Release Methylphenidate (Ritalin®)(OND003IND)
Tong Lee
NCT01377662
Ovarian Hormones and Stress Induced Drug Craving
Medical University of South Carolina
NCT02098434
Efficacy of Mirtazapine in Depressed Cocaine Dependent Subjects
Boston University
NCT00322309
Exercise as a Behavioral Treatment for Cocaine Dependence
Baylor College of Medicine
NCT01601743
Caffeine and Cocaine
Virginia Commonwealth University
NCT00733993
Open-Label Pilot Study of Lisdexamfetamine for Cocaine Dependence
New York State Psychiatric Institute
NCT01486810
n-Acetylcysteine and Cocaine
University of Kentucky
NCT02141620
Glutamatergic Modulation of Cocaine-related Deficits
New York State Psychiatric Institute
NCT01790490
Glutamate-Glutamine Cycling (VCYC) During Cocaine Abstinence Using 1H-MRS
Yale University
NCT02124941
Gender Differences in Response to Cues in Cocaine Dependence
Medical University of South Carolina
NCT00969943
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 10 |
| Phase 2 | 17 |
Top Sponsors
Named interventions
Most-linked intervention names on Cocaine Dependence records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Cocaine Dependence trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Cocaine Dependence page
40 registered trials, 3 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 3 Cocaine Dependence trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Yale University sponsors the most Cocaine Dependence trials on record, review their full trial history before evaluating a specific study. See Yale University's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Cocaine Dependence condition card totals 40 registered trials; most-linked intervention Placebo; top US site state Texas. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.