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NCT06282146 · ClinicalTrials.gov registry record · Early Phase 1
Testing a Transdiagnostic TMS Treatment Target
A Early Phase 1 study of Depression and Major Depressive Disorder, sponsored by Brigham and Women's Hospital.
- Active
- Registry status
- Early Phase 1
- Development phase
- 10
- Enrollment target
- 1
- Study location
NCT06282146: Active Early Phase 1 study of Depression and Major Depressive Disorder, sponsored by Brigham and Women's Hospital.
NCT06282146 is a Early Phase 1 study of Depression and Major Depressive Disorder that is active but no longer recruiting, run by Brigham and Women's Hospital. The registered enrollment target is 10 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06282146, a Early Phase 1 study of Depression and Major Depressive Disorder, is active but no longer recruiting, sponsored by Brigham and Women's Hospital.
- ACTIVE NOT RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 10 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to test a new brain stimulation treatment target for individuals with depression plus at least one additional psychiatric disorder. The main question is to understand the safety profile of a non-invasive form of brain stimulation called accelerated intermittent theta burst stimulation when it is targeting the posterior parietal cortex. Additional questions focus on whether this stimulation improves symptoms of depression and other psychiatric disorders as well as whether this stimulation changes brain function.
Primary Outcome
Questionnaire asking about the incidence, frequency, and severity of common TMS-related side effects such as headache, tinnitus, and neck pain. Higher severity and frequency of side effects indicates lower tolerability
Conditions Studied
Interventions
- PROCEDURE transcranial magnetic stimulation
Study Locations (1)
Massachusetts
- Brigham and Women's Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2024-09-09 |
| Est. Completion | 2026-05-01 |
| Phase | Early Phase 1 |
What the registry record for NCT06282146 still lists
NCT06282146 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 786-participant average among 679 other Depression trials with a reported enrollment target (99% lower).
The record links to 8 conditions, with Depression appearing as the primary indexed condition, and to 1 intervention - of which transcranial magnetic stimulation is the first listed.
NCT06282146 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT06282146 about?
NCT06282146 is a clinical study titled "Testing a Transdiagnostic TMS Treatment Target". The goal of this clinical trial is to test a new brain stimulation treatment target for individuals with depression plus at least one additional psychiatric disorder. The main question is to understand the safety profile of a non-invasive form of brain stimulation called accelerated intermittent the...
What is the current status of trial NCT06282146?
This trial is currently active not recruiting. It is a Early Phase 1 study. The enrollment target is 10 participants. The study started on 2024-09-09. Estimated completion is 2026-05-01.
What conditions does trial NCT06282146 study?
This clinical trial studies the following conditions: Depression, Major Depressive Disorder, PTSD, Anxiety Disorders, Mood Disorders.
What interventions are being tested in trial NCT06282146?
The interventions under investigation include: transcranial magnetic stimulation (PROCEDURE).
Who is sponsoring clinical trial NCT06282146?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06282146 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06282146's enrollment target sits among peer trials
10 659th of 679 higher than 17 of 679 other Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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