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NCT03859297 · ClinicalTrials.gov registry record · NA
Mechanisms of Rumination Change in Adolescent Depression
A NA study of Major Depressive Disorder and Mood Disorders, sponsored by Ohio State University.
- Recruiting
- Registry status
- NA
- Development phase
- 183
- Enrollment target
- 3
- Study locations
NCT03859297: Recruiting NA study of Major Depressive Disorder and Mood Disorders, sponsored by Ohio State University.
NCT03859297 is a NA study of Major Depressive Disorder and Mood Disorders that is actively recruiting participants, run by Ohio State University. The registered enrollment target is 183 participants, below the 376-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (51% lower). The trial reports 3 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03859297, a NA study of Major Depressive Disorder and Mood Disorders, is actively recruiting participants, sponsored by Ohio State University.
- RECRUITING
- Registry status
- NA
- Development phase
- 183 participants
- Enrollment target
- 3
- Study locations
Study Summary
This study will evaluate whether a newer treatment, rumination-focused cognitive behavioral treatment, which includes mindfulness and can be used to reduce ruminative habits, change ways in which key brain regions interact with each other (e.g.., often called connectivity), and whether these changes in habits and brain connectivity can reduce the risk for recurrence of depression in the next two years.
Primary Outcome
RRS is a scale developed by Dr. Susan Nolan-Hoeksema that is used to determine pre-post reductions in rumination after RF-CBT. The RRS is the Rumination Responsiveness Scale. Scores range from a low of 22 to a high of 88 on the 232 item scale. Higher scores indicate more difficulties with rumination. Higher rumination has been reported in a number of samples of both active and remitted MDD. The outcome is a reliable change index decline of at least 1/2 standard deviation in the RF-CBT group re
Conditions Studied
Interventions
- BEHAVIORAL Rumination-Focused CBT
- BEHAVIORAL Relaxation-based Therapy
Study Locations (3)
Ohio
- Nationwide Children's Hospital - Columbus
- The Ohio State University - Columbus
Utah
- University of Utah - Salt Lake City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 183 participants |
| Start Date | 2019-05-01 |
| Est. Completion | 2029-03-02 |
| Phase | NA |
What NCT03859297 shows while recruiting
NCT03859297 is an interventional study that assigns participants to a tested intervention. The registered 183 participants enrollment target is mid-sized for trials with a published cap, below the 376-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (51% lower).
The record links to 2 conditions, with Major Depressive Disorder appearing as the primary indexed condition, and to 2 interventions - of which Rumination-Focused CBT is the first listed.
NCT03859297 reports a single indexed study location in Ohio, Utah.
Frequently Asked Questions
What is clinical trial NCT03859297 about?
NCT03859297 is a clinical study titled "Mechanisms of Rumination Change in Adolescent Depression". This study will evaluate whether a newer treatment, rumination-focused cognitive behavioral treatment, which includes mindfulness and can be used to reduce ruminative habits, change ways in which key brain regions interact with each other (e.g.., often called connectivity), and whether these changes...
What is the current status of trial NCT03859297?
This trial is currently recruiting. It is a NA study. The enrollment target is 183 participants. The study started on 2019-05-01. Estimated completion is 2029-03-02.
What conditions does trial NCT03859297 study?
This clinical trial studies the following conditions: Major Depressive Disorder, Mood Disorders.
What interventions are being tested in trial NCT03859297?
The interventions under investigation include: Rumination-Focused CBT (BEHAVIORAL), Relaxation-based Therapy (BEHAVIORAL).
Who is sponsoring clinical trial NCT03859297?
This trial is sponsored by Ohio State University, which has 552 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03859297 being conducted?
This trial has 3 study locations across Ohio, Utah. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Major Depressive Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03859297's enrollment target sits among peer trials
183 82nd of 282 higher than 201 of 282 other Major Depressive Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Major Depressive Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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