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Mild Cognitive Impairment clinical trials
100 of 206 indexed Mild Cognitive Impairment trials are currently recruiting.
206 US clinical trials · 100 currently recruiting
Mild Cognitive Impairment is the subject of 206 registered US clinical trials on ClinicalTrials.gov, 100 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 52 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 9 of these trials.
The research picture
Mild Cognitive Impairment has 206 registered US clinical trials, 100 of them open to new participants right now, about 49% of the total.
- 100
- recruiting participants now
- 49%
- of trials open to enrollment
- 8
- in Phase 3–4 (later-stage)
- 9
- top sponsor: Massachusetts General Hospital
Active & Recent Trials
206 total, page 4 of 5
A 28-Week Open Label Extension Study Evaluating Safety and Tolerability of Donepezil Hydrochloride in Subjects With Mild Cognitive Impairment
Eisai
NCT00934375
Effect of Cerefolin®/CerefolinNAC® on Biomarker Measurements
Pamlab
NCT01745198
Facilitating Optimal Routines in Aging
University of Pittsburgh
NCT03913637
Music Therapy Experiences in Patients With Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD)
Icahn School of Medicine at Mount Sinai
NCT04666077
Retaining Cognition While Avoiding Late-Life Depression
University of Pittsburgh
NCT01886586
Combination Treatment Study for Memory Impairment and Depression
New York State Psychiatric Institute
NCT01658228
Lithium As a Treatment to Prevent Impairment of Cognition in Elders
Ariel Gildengers, MD
NCT03185208
Neurotrack Test Validation Protocol
NYU Langone Health
NCT02608021
Cognitive Detection of Preclinical AD: Validation Using Biomarkers
NYU Langone Health
NCT02616679
Metformin in Amnestic Mild Cognitive Impairment
Columbia University
NCT00620191
Speed of Processing Training to Improve Cognition in Traumatic Brain Injury and Mild Cognitive Impairment
Kessler Foundation
NCT02020564
Automated Retinal Image Analysis System (EyeQuant) for Computation of Vascular Biomarkers
Mayo Clinic
NCT04567745
Candesartan's Effects on Alzheimer's Disease And Related Biomarkers
Emory University
NCT02646982
Effects of Memory Boot Camp on Brain Function in Adults With Symptoms of Mild Cognitive Impairment (MCI)
Neurocore
NCT04426162
CAPABLE Family Pilot - Adapting CAPABLE for Older Adults With Mild Cognitive Impairment (MCI)/Early Stage Dementia and Their Care Partners
Johns Hopkins University
NCT05187117
Precision Medicine Approach for Early Dementia & Mild Cognitive Impairment
Alzheimer's Prevention and Reversal Project
NCT05894954
Cognitive Screening and Cognitive Training in Seniors
The University of Texas at Dallas
NCT02588209
Virtual Exercise For Older Adults With Mild Cognitive Impairment
Oregon Research Institute
NCT05318703
Noninvasive Brain Stimulation for Mild Cognitive Impairment
Palo Alto Veterans Institute for Research
NCT03331796
A Study of CST-2032 and CST-107 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Parkinson's or Alzheimer's Disease
CuraSen Therapeutics
NCT05104463
Macronutrient Effects on Alzheimer's Disease (MEAL-2)
Wake Forest University Health Sciences
NCT02463084
Treating Cancer-Related Fatigue Through Systematic Light Exposure
Icahn School of Medicine at Mount Sinai
NCT01873794
Impact of Combined Behavioral Interventions on Cognitive Outcomes in MCI
University of California, San Diego
NCT02864069
Wayfinding Intervention in High-Fidelity Long-Term Memory
University of California, San Francisco
NCT04253587
Cognitive Training in Mild Cognitive Impairment
University of Missouri-Columbia
NCT04899089
Consumption of Potatoes, Avocados and Chickpeas and Cognitive Function in Older Adults
Tufts University
NCT01620567
SNIFF - Combo INI+EMPA Trial
Wake Forest University Health Sciences
NCT05081219
Preventing Loss of Independence Through Exercise (PLIÉ) in Persons With Mild Cognitive Impairment (MCI)
University of California, San Francisco
NCT03526146
Brain Connections and Blood Pressure
Ohio State University
NCT03736434
Platform-based Mild Cognitive Impairment (MCI) Trial
Allison Gibson
NCT03987464
Study of Nasal Insulin to Fight Forgetfulness - Long-acting Insulin Detemir - 120 Days (SL120)
Wake Forest University Health Sciences
NCT01595646
UCLA Fitness and Memory Study of Activity In Mild Cognitive Impairment (AIM)
University of California, Los Angeles
NCT02001441
Remote Cognitive Assessment for Surgical Patients
University of California, San Francisco
NCT05566275
Early Detection of Mild Cognitive Impairment in Individual Patients
Louisiana State University Health Sciences Center Shreveport
NCT00243451
Effects Multimodal Mind and Body Approach for MCI
Massachusetts General Hospital
NCT06814483
A Trial of Neurocognitive and Supportive Therapy Interventions for Individuals With Parkinson's Disease
Virginia Commonwealth University
NCT01646333
Activity & Cognition After Treatment for Breast Cancer
University of Illinois at Urbana-Champaign
NCT02592070
Thermoregulation and Cognition During Cool Ambient Exposure in Tetraplegia
James J. Peters Veterans Affairs Medical Center
NCT02379156
Cognitive Outcomes of Brain Stimulation As a Later-in-Life Treatment
University of Texas Southwestern Medical Center
NCT05564715
SimpleC Wellness Platform With Social Robot Interaction
SimpleC
NCT05296239
Allopregnanolone for Mild Cognitive Impairment Due to Alzheimer's Disease or Mild AD
University of Southern California
NCT02221622
Computerized Memory Enhancing Treatment in MCI
Vanderbilt University Medical Center
NCT05332522
Rhythmically Entrained Exercise in Community-Dwelling Older Adults
University of North Carolina, Greensboro
NCT05462977
Hearing Aid and Individuals With Cognitive Disorders
Yu-Hsiang Wu
NCT04049643
Neurodegenerative Alzheimer's Disease and Amyotrophic Lateral Sclerosis (NADALS) Basket Trial
Massachusetts General Hospital
NCT05189106
A Pilot Randomized Controlled Trial: CoINTEGRATE
University of Michigan
NCT05732285
In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment: Rural Homes
University of California, Berkeley
NCT05159583
A Trial to Evaluate the Effects of BCG in Adults With MCI and Mild-to-Moderate AD
Steven E Arnold, MD
NCT05004688
Feasibility of Gamma Transcranial Alternating Current Stimulation to Reduce Beta-amyloid Load and Improve Memory
University of California, San Francisco
NCT04646499
Use of an Internet-Based Insomnia Intervention to Prevent Cognitive Decline in Adults With Mild Cognitive Impairment
University of Virginia
NCT04382365
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 24 |
| Phase 2 | 28 |
| Phase 3 | 3 |
| Phase 4 | 5 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Mild Cognitive Impairment Trial Landscape
206 indexed Mild Cognitive Impairment studies · 100 recruiting (49%).
Phase mix: 8 late (III/IV) vs 52 early (I/II).
Top sponsor: Massachusetts General Hospital (9 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Mild Cognitive Impairment?
PlainTrial tracks 206 US clinical trials for Mild Cognitive Impairment, of which 100 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Mild Cognitive Impairment?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.