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ClinicalTrials.gov 100 recruiting now official registry

Mild Cognitive Impairment clinical trials

100 of 206 indexed Mild Cognitive Impairment trials are currently recruiting.

206 US clinical trials · 100 currently recruiting

Mild Cognitive Impairment is the subject of 206 registered US clinical trials on ClinicalTrials.gov, 100 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 52 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 9 of these trials.

The research picture

Mild Cognitive Impairment has 206 registered US clinical trials, 100 of them open to new participants right now, about 49% of the total.

100
recruiting participants now
49%
of trials open to enrollment
8
in Phase 3–4 (later-stage)
9
top sponsor: Massachusetts General Hospital
Phase 124Phase 228Phase 33Phase 45

Active & Recent Trials

206 total, page 4 of 5

COMPLETED Phase 4 145 participants

A 28-Week Open Label Extension Study Evaluating Safety and Tolerability of Donepezil Hydrochloride in Subjects With Mild Cognitive Impairment

Eisai

NCT00934375

COMPLETED 121 participants

Effect of Cerefolin®/CerefolinNAC® on Biomarker Measurements

Pamlab

NCT01745198

COMPLETED NA 105 participants

Facilitating Optimal Routines in Aging

University of Pittsburgh

NCT03913637

COMPLETED NA 100 participants

Music Therapy Experiences in Patients With Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD)

Icahn School of Medicine at Mount Sinai

NCT04666077

COMPLETED NA 94 participants

Retaining Cognition While Avoiding Late-Life Depression

University of Pittsburgh

NCT01886586

COMPLETED Phase 4 86 participants

Combination Treatment Study for Memory Impairment and Depression

New York State Psychiatric Institute

NCT01658228

COMPLETED Phase 4 83 participants

Lithium As a Treatment to Prevent Impairment of Cognition in Elders

Ariel Gildengers, MD

NCT03185208

COMPLETED 81 participants

Neurotrack Test Validation Protocol

NYU Langone Health

NCT02608021

COMPLETED 81 participants

Cognitive Detection of Preclinical AD: Validation Using Biomarkers

NYU Langone Health

NCT02616679

COMPLETED Phase 2 80 participants

Metformin in Amnestic Mild Cognitive Impairment

Columbia University

NCT00620191

COMPLETED NA 80 participants

Speed of Processing Training to Improve Cognition in Traumatic Brain Injury and Mild Cognitive Impairment

Kessler Foundation

NCT02020564

COMPLETED Phase 1 80 participants

Automated Retinal Image Analysis System (EyeQuant) for Computation of Vascular Biomarkers

Mayo Clinic

NCT04567745

COMPLETED Phase 2 77 participants

Candesartan's Effects on Alzheimer's Disease And Related Biomarkers

Emory University

NCT02646982

COMPLETED NA 76 participants

Effects of Memory Boot Camp on Brain Function in Adults With Symptoms of Mild Cognitive Impairment (MCI)

Neurocore

NCT04426162

COMPLETED NA 74 participants

CAPABLE Family Pilot - Adapting CAPABLE for Older Adults With Mild Cognitive Impairment (MCI)/Early Stage Dementia and Their Care Partners

Johns Hopkins University

NCT05187117

COMPLETED Phase 3 73 participants

Precision Medicine Approach for Early Dementia & Mild Cognitive Impairment

Alzheimer's Prevention and Reversal Project

NCT05894954

COMPLETED NA 71 participants

Cognitive Screening and Cognitive Training in Seniors

The University of Texas at Dallas

NCT02588209

COMPLETED NA 69 participants

Virtual Exercise For Older Adults With Mild Cognitive Impairment

Oregon Research Institute

NCT05318703

COMPLETED NA 69 participants

Noninvasive Brain Stimulation for Mild Cognitive Impairment

Palo Alto Veterans Institute for Research

NCT03331796

COMPLETED Phase 2 64 participants

A Study of CST-2032 and CST-107 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Parkinson's or Alzheimer's Disease

CuraSen Therapeutics

NCT05104463

COMPLETED NA 60 participants

Macronutrient Effects on Alzheimer's Disease (MEAL-2)

Wake Forest University Health Sciences

NCT02463084

COMPLETED NA 54 participants

Treating Cancer-Related Fatigue Through Systematic Light Exposure

Icahn School of Medicine at Mount Sinai

NCT01873794

COMPLETED NA 52 participants

Impact of Combined Behavioral Interventions on Cognitive Outcomes in MCI

University of California, San Diego

NCT02864069

COMPLETED NA 50 participants

Wayfinding Intervention in High-Fidelity Long-Term Memory

University of California, San Francisco

NCT04253587

COMPLETED NA 48 participants

Cognitive Training in Mild Cognitive Impairment

University of Missouri-Columbia

NCT04899089

COMPLETED NA 48 participants

Consumption of Potatoes, Avocados and Chickpeas and Cognitive Function in Older Adults

Tufts University

NCT01620567

COMPLETED Phase 2 47 participants

SNIFF - Combo INI+EMPA Trial

Wake Forest University Health Sciences

NCT05081219

COMPLETED NA 41 participants

Preventing Loss of Independence Through Exercise (PLIÉ) in Persons With Mild Cognitive Impairment (MCI)

University of California, San Francisco

NCT03526146

COMPLETED NA 38 participants

Brain Connections and Blood Pressure

Ohio State University

NCT03736434

COMPLETED NA 38 participants

Platform-based Mild Cognitive Impairment (MCI) Trial

Allison Gibson

NCT03987464

COMPLETED Phase 2 37 participants

Study of Nasal Insulin to Fight Forgetfulness - Long-acting Insulin Detemir - 120 Days (SL120)

Wake Forest University Health Sciences

NCT01595646

COMPLETED 35 participants

UCLA Fitness and Memory Study of Activity In Mild Cognitive Impairment (AIM)

University of California, Los Angeles

NCT02001441

COMPLETED 34 participants

Remote Cognitive Assessment for Surgical Patients

University of California, San Francisco

NCT05566275

COMPLETED 34 participants

Early Detection of Mild Cognitive Impairment in Individual Patients

Louisiana State University Health Sciences Center Shreveport

NCT00243451

COMPLETED Phase 1 32 participants

Effects Multimodal Mind and Body Approach for MCI

Massachusetts General Hospital

NCT06814483

COMPLETED NA 32 participants

A Trial of Neurocognitive and Supportive Therapy Interventions for Individuals With Parkinson's Disease

Virginia Commonwealth University

NCT01646333

COMPLETED NA 31 participants

Activity & Cognition After Treatment for Breast Cancer

University of Illinois at Urbana-Champaign

NCT02592070

COMPLETED Phase 4 30 participants

Thermoregulation and Cognition During Cool Ambient Exposure in Tetraplegia

James J. Peters Veterans Affairs Medical Center

NCT02379156

COMPLETED NA 27 participants

Cognitive Outcomes of Brain Stimulation As a Later-in-Life Treatment

University of Texas Southwestern Medical Center

NCT05564715

COMPLETED NA 26 participants

SimpleC Wellness Platform With Social Robot Interaction

SimpleC

NCT05296239

COMPLETED Phase 1 24 participants

Allopregnanolone for Mild Cognitive Impairment Due to Alzheimer's Disease or Mild AD

University of Southern California

NCT02221622

COMPLETED NA 19 participants

Computerized Memory Enhancing Treatment in MCI

Vanderbilt University Medical Center

NCT05332522

COMPLETED NA 18 participants

Rhythmically Entrained Exercise in Community-Dwelling Older Adults

University of North Carolina, Greensboro

NCT05462977

COMPLETED NA 17 participants

Hearing Aid and Individuals With Cognitive Disorders

Yu-Hsiang Wu

NCT04049643

COMPLETED Phase 1 17 participants

Neurodegenerative Alzheimer's Disease and Amyotrophic Lateral Sclerosis (NADALS) Basket Trial

Massachusetts General Hospital

NCT05189106

COMPLETED NA 15 participants

A Pilot Randomized Controlled Trial: CoINTEGRATE

University of Michigan

NCT05732285

COMPLETED NA 15 participants

In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment: Rural Homes

University of California, Berkeley

NCT05159583

COMPLETED Phase 2 15 participants

A Trial to Evaluate the Effects of BCG in Adults With MCI and Mild-to-Moderate AD

Steven E Arnold, MD

NCT05004688

COMPLETED NA 14 participants

Feasibility of Gamma Transcranial Alternating Current Stimulation to Reduce Beta-amyloid Load and Improve Memory

University of California, San Francisco

NCT04646499

COMPLETED NA 12 participants

Use of an Internet-Based Insomnia Intervention to Prevent Cognitive Decline in Adults With Mild Cognitive Impairment

University of Virginia

NCT04382365

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Phase Distribution

PhaseTrial count
Phase 1 24
Phase 2 28
Phase 3 3
Phase 4 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Mild Cognitive Impairment Trial Landscape

206 indexed Mild Cognitive Impairment studies · 100 recruiting (49%).

Phase mix: 8 late (III/IV) vs 52 early (I/II).

Top sponsor: Massachusetts General Hospital (9 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Mild Cognitive Impairment?

PlainTrial tracks 206 US clinical trials for Mild Cognitive Impairment, of which 100 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Mild Cognitive Impairment?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.