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Mild Cognitive Impairment: early-phase trial registry
100 of 206 indexed Mild Cognitive Impairment trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #45 of 28,707 conditions by registered trial count.
206 US clinical trials · 100 currently recruiting · #45 of 28,707 conditions by registered trial count
Mild Cognitive Impairment: 206 US clinical trials tracked, 100 recruiting.
Mild Cognitive Impairment is the subject of 206 registered US clinical trials on ClinicalTrials.gov, 100 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 52 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 9 of these trials.
Enrollment posture brief
Registry condition mild-cognitive-impairment
OPEN 100 | RECR 49% | LATE 8 | EARLY 52 | RANK #45 | SPON 9
Volume-matched condition peers
Nearest open-share peer: Chronic Graft Versus Host Disease (48% recruiting · 31 trials)
Mild Cognitive Impairment lists 100 open slots (49% of 206 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Mild Cognitive Impairment on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Mild Cognitive Impairment is recruiting above its size-band peers.
100 of 206 indexed trials (48.5%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Mild Cognitive Impairment trials is spread across many organizations.
Massachusetts General Hospital accounts for 9 of 206 trials (4.4%). 114 distinct sponsors appear on at least one study for this condition label.
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Typical Mild Cognitive Impairment enrolment sits around 81 participants.
Median target enrolment is 81 among the 206 trials that report a genuine target (sentinel values excluded). 114 of those (55.3%) plan for fewer than 100 participants.
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Mild Cognitive Impairment research is mostly interventional.
168 interventional and 38 observational studies make up this index (81.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
206 total, page 4 of 5
A 28-Week Open Label Extension Study Evaluating Safety and Tolerability of Donepezil Hydrochloride in Subjects With Mild Cognitive Impairment
Eisai
NCT00934375
Effect of Cerefolin®/CerefolinNAC® on Biomarker Measurements
Pamlab
NCT01745198
Facilitating Optimal Routines in Aging
University of Pittsburgh
NCT03913637
Music Therapy Experiences in Patients With Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD)
Icahn School of Medicine at Mount Sinai
NCT04666077
Retaining Cognition While Avoiding Late-Life Depression
University of Pittsburgh
NCT01886586
Combination Treatment Study for Memory Impairment and Depression
New York State Psychiatric Institute
NCT01658228
Lithium As a Treatment to Prevent Impairment of Cognition in Elders
Ariel Gildengers, MD
NCT03185208
Neurotrack Test Validation Protocol
NYU Langone Health
NCT02608021
Cognitive Detection of Preclinical AD: Validation Using Biomarkers
NYU Langone Health
NCT02616679
Metformin in Amnestic Mild Cognitive Impairment
Columbia University
NCT00620191
Speed of Processing Training to Improve Cognition in Traumatic Brain Injury and Mild Cognitive Impairment
Kessler Foundation
NCT02020564
Automated Retinal Image Analysis System (EyeQuant) for Computation of Vascular Biomarkers
Mayo Clinic
NCT04567745
Candesartan's Effects on Alzheimer's Disease And Related Biomarkers
Emory University
NCT02646982
Effects of Memory Boot Camp on Brain Function in Adults With Symptoms of Mild Cognitive Impairment (MCI)
Neurocore
NCT04426162
CAPABLE Family Pilot - Adapting CAPABLE for Older Adults With Mild Cognitive Impairment (MCI)/Early Stage Dementia and Their Care Partners
Johns Hopkins University
NCT05187117
Precision Medicine Approach for Early Dementia & Mild Cognitive Impairment
Alzheimer's Prevention and Reversal Project
NCT05894954
Cognitive Screening and Cognitive Training in Seniors
The University of Texas at Dallas
NCT02588209
Virtual Exercise For Older Adults With Mild Cognitive Impairment
Oregon Research Institute
NCT05318703
Noninvasive Brain Stimulation for Mild Cognitive Impairment
Palo Alto Veterans Institute for Research
NCT03331796
A Study of CST-2032 and CST-107 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Parkinson's or Alzheimer's Disease
CuraSen Therapeutics
NCT05104463
Macronutrient Effects on Alzheimer's Disease (MEAL-2)
Wake Forest University Health Sciences
NCT02463084
Treating Cancer-Related Fatigue Through Systematic Light Exposure
Icahn School of Medicine at Mount Sinai
NCT01873794
Impact of Combined Behavioral Interventions on Cognitive Outcomes in MCI
University of California, San Diego
NCT02864069
Wayfinding Intervention in High-Fidelity Long-Term Memory
University of California, San Francisco
NCT04253587
Cognitive Training in Mild Cognitive Impairment
University of Missouri-Columbia
NCT04899089
Consumption of Potatoes, Avocados and Chickpeas and Cognitive Function in Older Adults
Tufts University
NCT01620567
SNIFF - Combo INI+EMPA Trial
Wake Forest University Health Sciences
NCT05081219
Preventing Loss of Independence Through Exercise (PLIÉ) in Persons With Mild Cognitive Impairment (MCI)
University of California, San Francisco
NCT03526146
Brain Connections and Blood Pressure
Ohio State University
NCT03736434
Platform-based Mild Cognitive Impairment (MCI) Trial
Allison Gibson
NCT03987464
Study of Nasal Insulin to Fight Forgetfulness - Long-acting Insulin Detemir - 120 Days (SL120)
Wake Forest University Health Sciences
NCT01595646
UCLA Fitness and Memory Study of Activity In Mild Cognitive Impairment (AIM)
University of California, Los Angeles
NCT02001441
Remote Cognitive Assessment for Surgical Patients
University of California, San Francisco
NCT05566275
Early Detection of Mild Cognitive Impairment in Individual Patients
Louisiana State University Health Sciences Center Shreveport
NCT00243451
Effects Multimodal Mind and Body Approach for MCI
Massachusetts General Hospital
NCT06814483
A Trial of Neurocognitive and Supportive Therapy Interventions for Individuals With Parkinson's Disease
Virginia Commonwealth University
NCT01646333
Activity & Cognition After Treatment for Breast Cancer
University of Illinois at Urbana-Champaign
NCT02592070
Thermoregulation and Cognition During Cool Ambient Exposure in Tetraplegia
James J. Peters Veterans Affairs Medical Center
NCT02379156
Cognitive Outcomes of Brain Stimulation As a Later-in-Life Treatment
University of Texas Southwestern Medical Center
NCT05564715
SimpleC Wellness Platform With Social Robot Interaction
SimpleC
NCT05296239
Allopregnanolone for Mild Cognitive Impairment Due to Alzheimer's Disease or Mild AD
University of Southern California
NCT02221622
Computerized Memory Enhancing Treatment in MCI
Vanderbilt University Medical Center
NCT05332522
Rhythmically Entrained Exercise in Community-Dwelling Older Adults
University of North Carolina, Greensboro
NCT05462977
Hearing Aid and Individuals With Cognitive Disorders
Yu-Hsiang Wu
NCT04049643
Neurodegenerative Alzheimer's Disease and Amyotrophic Lateral Sclerosis (NADALS) Basket Trial
Massachusetts General Hospital
NCT05189106
A Pilot Randomized Controlled Trial: CoINTEGRATE
University of Michigan
NCT05732285
In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment: Rural Homes
University of California, Berkeley
NCT05159583
A Trial to Evaluate the Effects of BCG in Adults With MCI and Mild-to-Moderate AD
Steven E Arnold, MD
NCT05004688
Feasibility of Gamma Transcranial Alternating Current Stimulation to Reduce Beta-amyloid Load and Improve Memory
University of California, San Francisco
NCT04646499
Use of an Internet-Based Insomnia Intervention to Prevent Cognitive Decline in Adults With Mild Cognitive Impairment
University of Virginia
NCT04382365
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 24 |
| Phase 2 | 28 |
| Phase 3 | 3 |
| Phase 4 | 5 |
Top Sponsors
Named interventions
Most-linked intervention names on Mild Cognitive Impairment records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Mild Cognitive Impairment trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Mild Cognitive Impairment page
206 registered trials, 100 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 100 Mild Cognitive Impairment trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Massachusetts General Hospital sponsors the most Mild Cognitive Impairment trials on record, review their full trial history before evaluating a specific study. See Massachusetts General Hospital's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Mild Cognitive Impairment condition card totals 206 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.