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NCT02463084 · ClinicalTrials.gov registry record · NA

Macronutrient Effects on Alzheimer's Disease (MEAL-2)

A NA study of Mild Cognitive Impairment and Insulin Resistance, sponsored by Wake Forest University Health Sciences.

Completed
Registry status
NA
Development phase
60
Enrollment target
1
Study location

NCT02463084: Completed NA study of Mild Cognitive Impairment and Insulin Resistance, sponsored by Wake Forest University Health Sciences.

NCT02463084 is a NA study of Mild Cognitive Impairment and Insulin Resistance that has completed, run by Wake Forest University Health Sciences. The registered enrollment target is 60 participants, below the 1,270-participant average among 205 other Mild Cognitive Impairment trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT02463084, a NA study of Mild Cognitive Impairment and Insulin Resistance, has completed, sponsored by Wake Forest University Health Sciences.

COMPLETED
Registry status
NA
Development phase
60 participants
Enrollment target
1
Study location

Study Summary

This study compares the effects of a one-month diet high in saturated fat (SF), glycemic index (GI), and salt (Na+) to a diet low in these nutritional parameters on memory and other cognitive functions, on MRI measures of brain structure, function, and perfusion, as well as on blood and cerebrospinal fluid levels of amyloid-beta (Aβ), insulin, lipids (total cholesterol, HDL, LDL, oxidized LDL, and triglycerides), cytokines, apolipoprotein E (ApoE), apolipoprotein J, cortisol, soluble low density lipoprotein receptor-related protein (sLRP), and glucose in middle-aged adults (45-65 years of age) with normal cognition or mild cognitive impairment.

Primary Outcome

CSF beta-amyloid 42

Conditions Studied

Mild Cognitive Impairment Insulin Resistance Prediabetic State Prehypertension Middle Age

Interventions

  • OTHER Low Diet
  • OTHER High Diet

Study Locations (1)

North Carolina

  • Wake Forest Baptist Health - Winston-Salem

Trial Details

FieldValue
Enrollment Target 60 participants
Start Date 2013-03
Est. Completion 2016-06
Phase NA
Wake Forest University Health Sciences

1,140 total trials

What the finished NCT02463084 record still lists

NCT02463084 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 1,270-participant average among 205 other Mild Cognitive Impairment trials with a reported enrollment target (95% lower).

The record links to 5 conditions, with Mild Cognitive Impairment appearing as the primary indexed condition, and to 2 interventions - of which Low Diet is the first listed.

NCT02463084 reports a single indexed study location in North Carolina.

Frequently Asked Questions

What is clinical trial NCT02463084 about?

NCT02463084 is a clinical study titled "Macronutrient Effects on Alzheimer's Disease (MEAL-2)". This study compares the effects of a one-month diet high in saturated fat (SF), glycemic index (GI), and salt (Na+) to a diet low in these nutritional parameters on memory and other cognitive functions, on MRI measures of brain structure, function, and perfusion, as well as on blood and cerebrospina...

What is the current status of trial NCT02463084?

This trial is currently completed. It is a NA study. The enrollment target is 60 participants. The study started on 2013-03. Estimated completion is 2016-06.

What conditions does trial NCT02463084 study?

This clinical trial studies the following conditions: Mild Cognitive Impairment, Insulin Resistance, Prediabetic State, Prehypertension, Middle Age.

What interventions are being tested in trial NCT02463084?

The interventions under investigation include: Low Diet (OTHER), High Diet (OTHER).

Who is sponsoring clinical trial NCT02463084?

This trial is sponsored by Wake Forest University Health Sciences, which has 1,140 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT02463084 being conducted?

This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Mild Cognitive Impairment

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT02463084's enrollment target sits among peer trials

60 124th of 205 higher than 73 of 205 other Mild Cognitive Impairment trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Mild Cognitive Impairment trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Related registry views

Source: ClinicalTrials.gov NCT02463084, the US trial registry maintained by the National Library of Medicine. NCT02463084 (small enrollment · single site footprint · completed) retrieved and formatted by PlainTrial, see methodology.