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ClinicalTrials.gov 89 recruiting now official registry

Melanoma clinical trials

89 of 269 indexed Melanoma trials are currently recruiting.

269 US clinical trials · 89 currently recruiting

Melanoma is the subject of 269 registered US clinical trials on ClinicalTrials.gov, 89 of them currently open to new participants. 19 are in Phase 3-4 (later-stage) and 184 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 20 of these trials.

The research picture

Melanoma has 269 registered US clinical trials, 89 of them open to new participants right now, about 33% of the total.

89
recruiting participants now
33%
of trials open to enrollment
19
in Phase 3–4 (later-stage)
20
top sponsor: Memorial Sloan Kettering Cancer Center
Phase 1117Phase 267Phase 316Phase 43

Active & Recent Trials

269 total, page 3 of 6

ACTIVE NOT RECRUITING Phase 3 633 participants

A Study to Evaluate ABP 206 Compared With OPDIVO® (Nivolumab) in Subjects With Unresectable or Metastatic Melanoma

Amgen

NCT06054555

ACTIVE NOT RECRUITING Phase 3 579 participants

A Study of Subcutaneous Nivolumab + Relatlimab Fixed-dose Combination (FDC) in Previously Untreated Metastatic or Unresectable Melanoma

Bristol-Myers Squibb

NCT05625399

ACTIVE NOT RECRUITING Phase 1 552 participants

A Study Evaluating AB248 Alone or in Combination With Pembrolizumab in Adult Patients With Solid Tumors

Asher Biotherapeutics

NCT05653882

ACTIVE NOT RECRUITING Phase 2 534 participants

Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)

Hoffmann-La Roche

NCT02568267

ACTIVE NOT RECRUITING Phase 1 400 participants

A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors

Pierre Fabre Medicament

NCT04913285

ACTIVE NOT RECRUITING Phase 1 350 participants

GEN1042 Safety Trial and Anti-tumor Activity in Participants With Malignant Solid Tumors

Genmab

NCT04083599

ACTIVE NOT RECRUITING Phase 1 322 participants

A PK Study to Compare GME751 (Proposed Pembrolizumab Biosimilar) and US-licensed and EU-authorized Keytruda® in Participants With Stage II and III Melanoma

Sandoz

NCT06153238

ACTIVE NOT RECRUITING Phase 1 320 participants

A Phase 1/2 Study of BA3071 in Patients With Solid Tumors

BioAtla

NCT05180799

ACTIVE NOT RECRUITING Phase 1 315 participants

Substudy 02B: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With First Line (1L) Advanced Melanoma (MK-3475-02B/KEYMAKER-U02)

Merck Sharp & Dohme

NCT04305054

ACTIVE NOT RECRUITING Phase 1 296 participants

Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)

Inhibrx Biosciences

NCT04198766

ACTIVE NOT RECRUITING Phase 2 267 participants

An Efficacy Study of Adjuvant Treatment With the Personalized Cancer Vaccine mRNA-4157 and Pembrolizumab in Participants With High-Risk Melanoma (KEYNOTE-942)

ModernaTX

NCT03897881

ACTIVE NOT RECRUITING Phase 3 257 participants

A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma

Pfizer

NCT04657991

ACTIVE NOT RECRUITING Phase 1 230 participants

A Study of APG-115 in as a Monotherapy or Combination With Pembrolizumab in Patients With Metastatic Melanomas or Advanced Solid Tumors

Ascentage Pharma Group

NCT03611868

ACTIVE NOT RECRUITING Phase 3 220 participants

Randomized Study Comparing Two Dosing Schedules for Hypofractionated Image-Guided Radiation Therapy

Memorial Sloan Kettering Cancer Center

NCT01223248

ACTIVE NOT RECRUITING Phase 2 194 participants

A Study of Ceralasertib Monotherapy and Ceralasertib Plus Durvalumab in Patients With Melanoma and Resistance to PD-(L)1 Inhibition

AstraZeneca

NCT05061134

ACTIVE NOT RECRUITING NA 180 participants

Comparison of Imaging Characteristics of uEXPLORER and Conventional PET/CT in Patients With Lung Cancer, Lymphoma, and Melanoma

University of California, Davis

NCT04478318

ACTIVE NOT RECRUITING Phase 1 179 participants

Study of NGM707 As Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies

NGM Biopharmaceuticals

NCT04913337

ACTIVE NOT RECRUITING Phase 1 153 participants

Study of EOS-448 With Standard of Care and/or Investigational Therapies in Participants With Advanced Solid Tumors

iTeos Belgium

NCT05060432

ACTIVE NOT RECRUITING Phase 2 151 participants

A Trial to Learn if Fianlimab and Cemiplimab Are Safe and Work Better Than Anti-PD1 Alone in Adult Participants With Resectable Stage 3 or 4 Melanoma

Regeneron Pharmaceuticals

NCT06190951

ACTIVE NOT RECRUITING Phase 2 147 participants

A Study of Participant Reported Preference for Subcutaneous Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) Over Intravenous Pembrolizumab (MK-3475) Formulation in Multiple Tumor Types (MK-3475A-F11)

Merck Sharp & Dohme

NCT06099782

ACTIVE NOT RECRUITING Phase 1 140 participants

A Phase I, Open-Label, Multi-center Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD6244 (ARRY-142886)

AstraZeneca

NCT00600496

ACTIVE NOT RECRUITING Phase 1 138 participants

A Study of TRK-950 in Combinations With Anti-Cancer Treatment Regimens in Patients With Advanced Solid Tumors

Toray Industries

NCT03872947

ACTIVE NOT RECRUITING Phase 1 137 participants

ENB003 Plus Pembrolizumab Phase 1b/2a in Solid Tumors

ENB Therapeutics

NCT04205227

ACTIVE NOT RECRUITING Phase 2 134 participants

Study of Efficacy and Safety of LXH254 Combinations in Patients With Previously Treated Unresectable or Metastatic Melanoma

Novartis Pharmaceuticals

NCT04417621

ACTIVE NOT RECRUITING Phase 2 134 participants

Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases

Brigham and Women's Hospital

NCT04899908

ACTIVE NOT RECRUITING Phase 1 120 participants

ADP-A2M4CD8 as Monotherapy or in Combination With Either Nivolumab or Pembrolizumab in HLA-A2+ Subjects With MAGE-A4 Positive Tumors (SURPASS)

Uswm CT

NCT04044859

ACTIVE NOT RECRUITING Phase 2 100 participants

A Study to Evaluate Whether Participants With Melanoma Prefer Subcutaneous vs Intravenous Administration of Nivolumab and Nivolumab + Relatlimab Fixed-dose Combinations

Bristol-Myers Squibb

NCT06101134

ACTIVE NOT RECRUITING Phase 1 98 participants

Study of Safety and Efficacy of DKY709 Alone or in Combination With PDR001 in Patients With Advanced Solid Tumors.

Novartis Pharmaceuticals

NCT03891953

ACTIVE NOT RECRUITING Phase 1 94 participants

Veliparib, Paclitaxel, and Carboplatin in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery and Liver or Kidney Dysfunction

National Cancer Institute (NCI)

NCT01366144

ACTIVE NOT RECRUITING 90 participants

Evaluating the Effects of Cannabis Use and Circulating Cannabinoids on Tumor Infiltrating Lymphocytes in Malignant Melanoma

University of Colorado, Denver

NCT05520294

ACTIVE NOT RECRUITING Phase 1 83 participants

A Study of HFB200603 as a Single Agent and in Combination With Tislelizumab in Adult Patients With Advanced Solid Tumors

HiFiBiO Therapeutics

NCT05789069

ACTIVE NOT RECRUITING Phase 1 83 participants

A Study of Cobolimab Plus Dostarlimab in Pediatric and Young Adult Participants With Cancer

GlaxoSmithKline

NCT06521567

ACTIVE NOT RECRUITING 72 participants

Analyzing Clinical Outcomes and Genomic Data of American Indian Patient Population

University of Oklahoma

NCT05863052

ACTIVE NOT RECRUITING Phase 1 72 participants

A Study of HFB200301 as a Single Agent and in Combination With Tislelizumab in Adult Patients With Advanced Solid Tumors

HiFiBiO Therapeutics

NCT05238883

ACTIVE NOT RECRUITING Phase 1 71 participants

MAGE-A4ᶜ¹º³²T for Multi-Tumor

Adaptimmune

NCT03132922

ACTIVE NOT RECRUITING Phase 2 71 participants

A Phase II Study of the Interleukin-6 Receptor Inhibitor Tocilizumab in Combination With Ipilimumab and Nivolumab in Patients With Unresectable Stage III or Stage IV Melanoma

NYU Langone Health

NCT03999749

ACTIVE NOT RECRUITING Phase 1 70 participants

Study of ARRY-614 Plus Either Nivolumab or Nivolumab+Ipilimumab

Dan Zandberg

NCT04074967

ACTIVE NOT RECRUITING Phase 2 70 participants

Study of Zirconium Zr 89 Crefmirlimab Berdoxam PET/CT in Subjects With Advanced or Metastatic Malignancies

ImaginAb

NCT05013099

ACTIVE NOT RECRUITING Phase 2 70 participants

Pembrolizumab and Ipilimumab After Prior Immunotherapy for Melanoma

University of Chicago

NCT02743819

ACTIVE NOT RECRUITING Phase 2 67 participants

Adjuvant Treatment Determined By Pathological Response To Neoadjvuant Nivolumab

Abramson Cancer Center at Penn Medicine

NCT04013854

ACTIVE NOT RECRUITING Phase 1 65 participants

A Study to Evaluate the Safety and Activity of Belvarafenib as a Single Agent and in Combination With Either Cobimetinib or Cobimetinib Plus Nivolumab in Patients With NRAS-mutant Advanced Melanoma.

Genentech

NCT04835805

ACTIVE NOT RECRUITING Phase 2 63 participants

Neoadjuvant PD-1 Blockade in Patients with Stage IIB/C Melanoma

Abramson Cancer Center at Penn Medicine

NCT03757689

ACTIVE NOT RECRUITING Phase 1 47 participants

Infliximab or Vedolizumab in Treating Immune Checkpoint Inhibitor-Related Colitis in Patients With Genitourinary Cancer or Melanoma

M.D. Anderson Cancer Center

NCT04407247

ACTIVE NOT RECRUITING Phase 2 43 participants

A Study of IO102/IO103, Nivolumab, and Relatlimab in People With Melanoma

Memorial Sloan Kettering Cancer Center

NCT05912244

ACTIVE NOT RECRUITING Phase 2 40 participants

QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors

ImmunityBio

NCT03228667

ACTIVE NOT RECRUITING NA 39 participants

Use of Serial Plasma NGS as a New Efficacy Metric to Guide Immunotherapy Treatment Discontinuation

Massachusetts General Hospital

NCT06146920

ACTIVE NOT RECRUITING Phase 1 35 participants

Study of MEDI0562 Prior to Surgical Resection in Head and Neck Squamous Cell Carcinoma (HNSCC) or Melanoma

Providence Health & Services

NCT03336606

ACTIVE NOT RECRUITING NA 32 participants

Using an End-of-life Conversation Game to Engage Patients With Cancer in Advance Care Planning: Phase 2

Milton S. Hershey Medical Center

NCT06384417

ACTIVE NOT RECRUITING Phase 1 28 participants

Ipilimumab (Immunotherapy) and MGN1703 (TLR Agonist) in Patients With Advanced Solid Malignancies

M.D. Anderson Cancer Center

NCT02668770

ACTIVE NOT RECRUITING Phase 2 28 participants

CD8+ T Cell Imaging During Pre-surgery Immunotherapy in People With Melanoma

Memorial Sloan Kettering Cancer Center

NCT05289193

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Phase Distribution

PhaseTrial count
Phase 1 117
Phase 2 67
Phase 3 16
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Melanoma Trial Landscape

269 indexed Melanoma studies · 89 recruiting (33%).

Phase mix: 19 late (III/IV) vs 184 early (I/II).

Top sponsor: Memorial Sloan Kettering Cancer Center (20 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Melanoma?

PlainTrial tracks 269 US clinical trials for Melanoma, of which 89 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Melanoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.