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NCT02743819 · ClinicalTrials.gov registry record · Phase 2
Pembrolizumab and Ipilimumab After Prior Immunotherapy for Melanoma
A Phase 2 study of Melanoma, sponsored by University of Chicago.
- Active
- Registry status
- Phase 2
- Development phase
- 70
- Enrollment target
- 10
- Study locations
NCT02743819: Active Phase 2 study of Melanoma, sponsored by University of Chicago.
NCT02743819 is a Phase 2 study of Melanoma that is active but no longer recruiting, run by University of Chicago. The registered enrollment target is 70 participants, below the 706-participant average among 266 other Melanoma trials with a reported enrollment target (90% lower). The trial reports 10 study locations across 5 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02743819, a Phase 2 study of Melanoma, is active but no longer recruiting, sponsored by University of Chicago.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 70 participants
- Enrollment target
- 10
- Study locations
Study Summary
Phase II study evaluating the benefit of the combination of anti-PD1 (pembrolizumab) and anti-CTLA4 (ipilimumab) antibodies in advanced melanoma. The study will determine the response rate of the combination and evaluate other clinical parameters such as progression-free survival and safety of the combination following anti-PD1/L1 antibody. The study will also provide the opportunity to investigate blood or tumor based factors that may predict response to anti-PD1 antibody in combination with anti-CTLA4.
Primary Outcome
Per Response Evaluation Criteria for use in trials testing immunotherapeutics (iRECIST) for target lesions and assessed by CT or MRI: Complete Response (CR), Disappearance of all target lesions; Partial Response (PR), \>=30% decrease in the sum of the longest diameter of target lesions; Overall Response (OR) = CR + PR
Conditions Studied
Interventions
- DRUG Pembrolizumab
- DRUG Ipilimumab
Study Locations (10)
Illinois
- University of Chicago - Chicago
- Decatur Memorial Hospital - Decatur
- NorthShore University HealthSystem - Evanston
- Oncology Specialists S.C. - Park Ridge
- Illinois Cancer Care - Peoria
Florida
- Mount Sinai Medical Center of Florida - Miami Beach
- H. Lee Moffitt Cancer Center and Research Institute - Tampa
Alabama
- University of South Alabama - Mobile
Indiana
- Fort Wayne Medical Oncology and Hematology, Inc. - Fort Wayne
Virginia
- Virginia Commonwealth University/ Massey Cancer Center - Richmond
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2016-06-28 |
| Est. Completion | 2026-06 |
| Phase | Phase 2 |
What the registry record for NCT02743819 still lists
NCT02743819 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 70 participants, a relatively small participant target, below the 706-participant average among 266 other Melanoma trials with a reported enrollment target (90% lower).
The record links to 1 condition, with Melanoma appearing as the primary indexed condition, and to 2 interventions - of which Pembrolizumab is the first listed.
NCT02743819 lists 10 locations in 5 states (Illinois, Florida, Alabama).
Frequently Asked Questions
What is clinical trial NCT02743819 about?
NCT02743819 is a clinical study titled "Pembrolizumab and Ipilimumab After Prior Immunotherapy for Melanoma". Phase II study evaluating the benefit of the combination of anti-PD1 (pembrolizumab) and anti-CTLA4 (ipilimumab) antibodies in advanced melanoma. The study will determine the response rate of the combination and evaluate other clinical parameters such as progression-free survival and safety of the c...
What is the current status of trial NCT02743819?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 70 participants. The study started on 2016-06-28. Estimated completion is 2026-06.
What conditions does trial NCT02743819 study?
This clinical trial studies the following conditions: Melanoma.
What interventions are being tested in trial NCT02743819?
The interventions under investigation include: Pembrolizumab (DRUG), Ipilimumab (DRUG).
Who is sponsoring clinical trial NCT02743819?
This trial is sponsored by University of Chicago, which has 796 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02743819 being conducted?
This trial has 10 study locations across Alabama, Florida, Illinois, Indiana, Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Melanoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02743819's enrollment target sits among peer trials
70 137th of 266 higher than 128 of 266 other Melanoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Melanoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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