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ClinicalTrials.gov 89 recruiting now official registry

Melanoma clinical trials

89 of 269 indexed Melanoma trials are currently recruiting.

269 US clinical trials · 89 currently recruiting

Melanoma is the subject of 269 registered US clinical trials on ClinicalTrials.gov, 89 of them currently open to new participants. 19 are in Phase 3-4 (later-stage) and 184 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 20 of these trials.

The research picture

Melanoma has 269 registered US clinical trials, 89 of them open to new participants right now, about 33% of the total.

89
recruiting participants now
33%
of trials open to enrollment
19
in Phase 3–4 (later-stage)
20
top sponsor: Memorial Sloan Kettering Cancer Center
Phase 1117Phase 267Phase 316Phase 43

Active & Recent Trials

269 total, page 4 of 6

ACTIVE NOT RECRUITING 28 participants

Improving Early Detection of Melanoma Recurrence With Circulating Tumor DNA (ctDNA)

University of Utah

NCT05736523

ACTIVE NOT RECRUITING Phase 1 26 participants

XL888 + Vemurafenib + Cobimetinib for Unresectable BRAF Mutated Stage III/IV Melanoma

H. Lee Moffitt Cancer Center and Research Institute

NCT02721459

ACTIVE NOT RECRUITING Phase 1 26 participants

A Study of Dapansutrile Plus Pembrolizumab in Patients With PD-1 Refractory Advanced Melanoma

April Salama, M.D.

NCT04971499

ACTIVE NOT RECRUITING Phase 2 22 participants

Adjuvant Nivolumab & Low Dose Ipilimumab for Stage III & Resected Stage IV Melanoma

Brown University

NCT02656706

ACTIVE NOT RECRUITING Phase 1 21 participants

Phase I, Open-Label, Study of Tumor Infiltrating Lymphocytes Engineered With Membrane Bound IL15 Plus Acetazolamide in Adult Patients With Metastatic Melanoma

M.D. Anderson Cancer Center

NCT05470283

ACTIVE NOT RECRUITING Phase 2 18 participants

Treating Patients With Melanoma and ALK Alterations With Ensartinib

Memorial Sloan Kettering Cancer Center

NCT03420508

ACTIVE NOT RECRUITING Phase 1 18 participants

Adoptive Cell Therapy Using Cancer Specific CD8+ Tumor Infiltrating Lymphocytes in Adult Patients With Solid Tumors

AgonOx

NCT05902520

ACTIVE NOT RECRUITING Phase 1 16 participants

QUILT-2.025 NANT Neoepitope Yeast Vaccine (YE-NEO-001): Adjuvant Immunotherapy Using a Personalized Neoepitope Yeast-Based Vaccine To Induce T-Cell Responses In Subjects W/ Previously Treated Cancers.

NantBioScience

NCT03552718

ACTIVE NOT RECRUITING Phase 1 15 participants

Oncolytic Adenovirus TILT-123 and Avelumab for Treatment of Solid Tumors Refractory to or Progressing After Anti-PD(L)1

TILT Biotherapeutics

NCT05222932

ACTIVE NOT RECRUITING Phase 1 15 participants

A Phase 1/2 Study of KSQ-001EX, Autologous Tumor Infiltrating Lymphocytes Engineered to Inactivate the SOCS1 Gene, in Patients With Select Advanced Solid Tumors

M.D. Anderson Cancer Center

NCT06237881

ACTIVE NOT RECRUITING Phase 2 14 participants

Nivolumab/Ipilimumab Plus Cabozantinib in Patients With Unresectable Advanced Melanoma

Georgetown University

NCT04091750

ACTIVE NOT RECRUITING Phase 1 14 participants

Transfer of Genetically Engineered Lymphocytes in Melanoma Patients

Loyola University

NCT01586403

ACTIVE NOT RECRUITING 12 participants

A Study of Tumor Imaging With Multispectral Optoacoustic Tomography

Memorial Sloan Kettering Cancer Center

NCT05488483

ACTIVE NOT RECRUITING Phase 1 11 participants

Vaccine Therapy and Pembrolizumab in Treating Patients With Solid Tumors That Have Failed Prior Therapy

City of Hope Medical Center

NCT02432963

ACTIVE NOT RECRUITING NA 11 participants

Proton Pencil Beam Scanning GRID for Treatment of Bulky Tumors

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT05121545

ACTIVE NOT RECRUITING Phase 1 8 participants

IT-hu14.18-IL2 With Radiation, Nivolumab and Ipilimumab for Melanoma

University of Wisconsin, Madison

NCT03958383

ACTIVE NOT RECRUITING NA 7 participants

PET Imaging of Solid Tumors Using 124I-Humanized 3F8: A Pilot Study

Memorial Sloan Kettering Cancer Center

NCT02307630

ACTIVE NOT RECRUITING Phase 1 6 participants

A Study to Learn About the Study Medicine Called PF-08046032 in People With Advanced Cancers

Pfizer

NCT06870487

COMPLETED 17,517 participants

Retrospective Assessment of AE-Related Healthcare Resource Utilization and Costs of Immune Checkpoint Inhibitor and Targeted Therapy for Adjuvant Treatment of Melanoma

Novartis Pharmaceuticals

NCT05874817

COMPLETED 1,429 participants

PRospective REgistry of Advanced Stage CancER (PREFER) Patients to Assess Prevalence of Actionable Biomarkers and Driver Mutations to Address Disparities in Precision Medicine

Labcorp Corporation of America Holdings

NCT05697198

COMPLETED 1,189 participants

Pattern of Use and Safety/Effectiveness of Nivolumab in Routine Oncology Practice

Bristol-Myers Squibb

NCT02847728

COMPLETED NA 1,000 participants

Targeted Melanoma Detection With Skin Self-Examination During COVID-19 Restricted Physician Access

Northwestern University

NCT04420273

COMPLETED Phase 3 906 participants

Efficacy Study of Nivolumab Compared to Ipilimumab in Prevention of Recurrence of Melanoma After Complete Resection of Stage IIIb/c or Stage IV Melanoma

Bristol-Myers Squibb

NCT02388906

COMPLETED Phase 3 783 participants

A Study of NKTR-214 Combined With Nivolumab vs Nivolumab Alone in Participants With Previously Untreated Inoperable or Metastatic Melanoma

Bristol-Myers Squibb

NCT03635983

COMPLETED 754 participants

Peripheral Blood and/or Bone Marrow, Including Detection of Occult Metastases, in Patients With Melanoma

Memorial Sloan Kettering Cancer Center

NCT00588198

COMPLETED Phase 3 498 participants

A Study of Vemurafenib Adjuvant Therapy in Participants With Surgically Resected Cutaneous BRAF-Mutant Melanoma

Hoffmann-La Roche

NCT01667419

COMPLETED Phase 3 437 participants

Efficacy and Safety Study of Talimogene Laherparepvec Compared to Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) in Melanoma

BioVex Limited

NCT00769704

COMPLETED NA 323 participants

Melanoma Risk Assessment & Tailored Intervention

University of Pennsylvania

NCT01356771

COMPLETED Phase 1 261 participants

A Study to Compare Nivolumab Drug Product Process D to Nivolumab Drug Product Process C in Participants With Stage IIIa/b/c/d or Stage IV Melanoma After Complete Resection

Bristol-Myers Squibb

NCT03980314

COMPLETED Phase 2 248 participants

A Companion Study for Patients Enrolled in Prior/Parent Ipilimumab Studies

Bristol-Myers Squibb

NCT00162123

COMPLETED Phase 2 196 participants

Study of Efficacy and Safety of Novel Spartalizumab Combinations in Patients With Previously Treated Unresectable or Metastatic Melanoma

Novartis Pharmaceuticals

NCT03484923

COMPLETED Phase 1 191 participants

Ph1b/2 Dose-Escalation Study of Entinostat With Pembrolizumab in Non-small Cell Lung Cancer (NSCLC) With Expansion Cohorts in NSCLC, Melanoma, and Colorectal Cancer (CRC)

Syndax Pharmaceuticals

NCT02437136

COMPLETED Phase 1 185 participants

A Study of LGK974 in Patients With Malignancies Dependent on Wnt Ligands

Novartis Pharmaceuticals

NCT01351103

COMPLETED Phase 2 170 participants

Lymphocyte Re-infusion During Immune Suppression to Treat Metastatic Melanoma

National Cancer Institute (NCI)

NCT00001832

COMPLETED 170 participants

Melanoma Risk-Reduction Among Patients and Family Members

M.D. Anderson Cancer Center

NCT00510302

COMPLETED Phase 3 161 participants

Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors

Dan Zandberg

NCT04157985

COMPLETED Phase 2 155 participants

A Single Arm Study of Ipilimumab Monotherapy in Patients With Previously Treated Unresectable Stage III or IV Melanoma

Bristol-Myers Squibb

NCT00289627

COMPLETED Phase 1 150 participants

A Study of XmAb®20717 in Subjects With Selected Advanced Solid Tumors

Xencor

NCT03517488

COMPLETED Phase 1 144 participants

A Safety and Efficacy Study of Intetumumab, Alone and in Combination With Dacarbazine, in Participants With Stage 4 Melanoma

Centocor

NCT00246012

COMPLETED Phase 2 133 participants

Phase II Trial of Allovectin-7® for Metastatic Melanoma

Vical

NCT00044356

COMPLETED Phase 2 119 participants

An Investigational Immuno-therapy Study to Evaluate Safety and Effectiveness in Patients With Melanoma That Has Spread to the Brain, Treated With Nivolumab in Combination With Ipilimumab, Followed by Nivolumab by Itself

Bristol-Myers Squibb

NCT02320058

COMPLETED 118 participants

Illness Related Distress in Women With Clinically Localized Cutaneous Melanoma

Memorial Sloan Kettering Cancer Center

NCT00745862

COMPLETED NA 116 participants

Internet-based Intervention for Skin Self-Examination in Participants With Increased Risk for Melanoma

Rutgers, The State University of New Jersey

NCT03725449

COMPLETED Phase 1 110 participants

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Melanoma (Morpheus-Melanoma)

Hoffmann-La Roche

NCT05116202

COMPLETED Phase 2 110 participants

Evaluating The Antitumor Activity Of MEDI-522 With Or Without Dacarbazine In Patients With Metastatic Melanoma

MedImmune

NCT00066196

COMPLETED Phase 1 100 participants

Substudy 02A: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents in Participants With Programmed Cell-death 1 (PD-1) Refractory Melanoma (MK-3475-02A/KEYMAKER-U02)

Merck Sharp & Dohme

NCT04305041

COMPLETED Phase 2 99 participants

Evaluation of Tumor Response to Ipilimumab in the Treatment of Melanoma With Brain Metastases

Bristol-Myers Squibb

NCT00623766

COMPLETED 98 participants

Immune Responses in Prostate, Lung, Melanoma and Breast Cancer Patients Following Stereotactic Body Radiotherapy (SBRT), Intensity Modulated Radiotherapy (IMRT) or Brachytherapy

Mayo Clinic

NCT01777802

COMPLETED Phase 1 89 participants

A Study of E7386 in Combination With Pembrolizumab in Previously Treated Participants With Selected Solid Tumors

Eisai

NCT05091346

COMPLETED NA 89 participants

Training Primary Care Physicians to Perform Melanoma Opportunistic Surveillance

Northwestern University

NCT02385253

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Phase Distribution

PhaseTrial count
Phase 1 117
Phase 2 67
Phase 3 16
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Melanoma Trial Landscape

269 indexed Melanoma studies · 89 recruiting (33%).

Phase mix: 19 late (III/IV) vs 184 early (I/II).

Top sponsor: Memorial Sloan Kettering Cancer Center (20 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Melanoma?

PlainTrial tracks 269 US clinical trials for Melanoma, of which 89 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Melanoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.