Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

ACTIVE NOT RECRUITING Phase 2

A Study of Participant Reported Preference for Subcutaneous Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) Over Intravenous Pembrolizumab (MK-3475) Formulation in Multiple Tumor Types (MK-3475A-F11)

NCT06099782 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to evaluate participant preference for coformulated hyaluronidase/pembrolizumab pembrolizumab (+) berahyaluronidase alfa administered subcutaneously (SC) over pembrolizumab (MK-3475) administered intravenously (IV) in participants with multiple tumor types. There will be no hypothesis testing in this study.

Interventions

  • BIOLOGICAL Pembrolizumab
  • BIOLOGICAL Pembrolizumab (+) Berahyaluronidase alfa

Study Locations (20)

Region M. de Santiago

  • FALP-UIDO ( Site 0401) — Santiago
  • Oncovida ( Site 0403) — Santiago
  • Pontificia Universidad Catolica de Chile-Hemato-Oncology ( Site 0407) — Santiago
  • Bradfordhill-Clinical Area ( Site 0402) — Santiago

Florida

  • Holy Cross Hospital-Clinical Research ( Site 0159) — Fort Lauderdale
  • Mid Florida Hematology and Oncology Center ( Site 0113) — Orange City

Alabama

  • Russell Medical ( Site 0160) — Alexander City

Alaska

  • Alaska Oncology and Hematology ( Site 0121) — Anchorage

Arkansas

  • Highlands Oncology Group-Research Department ( Site 0133) — Springdale

California

  • Marin Cancer Care ( Site 0148) — Greenbrae

Georgia

  • Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital-Research ( Site 0112) — Marietta

Washington

  • Kadlec Clinic Hematology and Oncology ( Site 0103) — Kennewick

Trial Details

FieldValue
Enrollment Target 147 participants
Start Date 2023-12-26
Est. Completion 2026-11-16
Phase Phase 2

Sponsor

Merck Sharp & Dohme

741 total trials

Interested in This Trial?

Always speak with your doctor before enrolling in a clinical trial.

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06099782

The ClinicalTrials.gov registry entry for NCT06099782 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 147 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 3 conditions, with Melanoma appearing as the primary indexed condition, and to 2 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06099782 reports 20 study locations spanning 16 distinct geographic areas — top geographies include Region M. de Santiago, Florida, Alabama. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06099782 about?

NCT06099782 is a clinical study titled "A Study of Participant Reported Preference for Subcutaneous Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) Over Intravenous Pembrolizumab (MK-3475) Formulation in Multiple Tumor Types (MK-3475A-F11)". The purpose of this study is to evaluate participant preference for coformulated hyaluronidase/pembrolizumab pembrolizumab (+) berahyaluronidase alfa administered subcutaneously (SC) over pembrolizumab (MK-3475) administered intravenously (IV) in participants with multiple tumor types. There will be...

What is the current status of trial NCT06099782?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 147 participants. The study started on 2023-12-26. Estimated completion is 2026-11-16.

What conditions does trial NCT06099782 study?

This clinical trial studies the following conditions: Melanoma, Non-Small Cell Lung Cancer, Renal Cell Carcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06099782?

The interventions under investigation include: Pembrolizumab (BIOLOGICAL), Pembrolizumab (+) Berahyaluronidase alfa (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06099782?

This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06099782 being conducted?

This trial has 20 study locations across Alabama, Alaska, Arkansas, California, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial