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NCT03228667 · ClinicalTrials.gov registry record · Phase 2
QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors
A Phase 2 study of Non-Small Cell Lung Cancer and Melanoma, sponsored by ImmunityBio.
- Active
- Registry status
- Phase 2
- Development phase
- 40
- Enrollment target
- 20
- Study locations
NCT03228667: Active Phase 2 study of Non-Small Cell Lung Cancer and Melanoma, sponsored by ImmunityBio.
NCT03228667 is a Phase 2 study of Non-Small Cell Lung Cancer and Melanoma that is active but no longer recruiting, run by ImmunityBio. The registered enrollment target is 40 participants, below the 652-participant average among 454 other Non-Small Cell Lung Cancer trials with a reported enrollment target (94% lower). The trial reports 20 study locations across 11 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03228667, a Phase 2 study of Non-Small Cell Lung Cancer and Melanoma, is active but no longer recruiting, sponsored by ImmunityBio.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 40 participants
- Enrollment target
- 20
- Study locations
Study Summary
QUILT-3.055 is a Phase 2b, open-label, multicohort study investigating combination immunotherapies in patients with advanced solid tumors who have previously been treated with PD-1/PD-L1 checkpoint inhibitors. The study aims to evaluate the safety and efficacy of NAI (nogapendekin alfa inbakicept) in combination with other agents like checkpoint inhibitors and cell therapies across various cancer types and treatment settings. The study includes multiple cohorts based on prior therapies and cancer types, with a focus on assessing overall response rate (ORR), overall survival (OS), and other measures of anti-tumor activity and immune response.
Primary Outcome
ORR reflects tumor shrinkage and is the key measure of antitumor activity.
Conditions Studied
Interventions
- DRUG N-803 + Pembrolizumab
- DRUG N-803 + Nivolumab
- DRUG N-803 + Atezolizumab
- DRUG N-803 + Avelumab
- DRUG N-803 + Durvalumab
Study Locations (20)
California
- Chan Soon-Shiong Institute for Medicine - El Segundo
- MemorialCare Health System - Fountain Valley
- Glendale Adventist Medical Center - Glendale
- University of Southern California Norris Comprehensive Cancer Center - Los Angeles
- Desert Hematology Oncology Medical Group, Inc. - Rancho Mirage
Florida
- Memorial Healthcare System - Hollywood
- Miami Cancer Institute (Baptist Health South Florida) - Miami
- University of Miami - Miami
Missouri
- Mercy Research Joplin - Joplin
- Mercy Clinic Cancer & Hematology - Chub O'Reilly Cancer Center - Springfield
- Washington University School of Medicine - St Louis
Kentucky
- Baptist Health - Lexington - Lexington
- Baptist Health- Louisville - Louisville
Alaska
- Alaska Clinical Research Center - Anchorage
Arkansas
- Genesis Cancer Center - Hot Springs
Indiana
- Horizon Oncology Associates - Lafayette
Iowa
- University of Iowa Holden Comprehensive Cancer Center - Iowa City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2018-12-11 |
| Est. Completion | 2030-12-31 |
| Phase | Phase 2 |
What the registry record for NCT03228667 still lists
NCT03228667 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 652-participant average among 454 other Non-Small Cell Lung Cancer trials with a reported enrollment target (94% lower).
The record links to 10 conditions, with Non-Small Cell Lung Cancer appearing as the primary indexed condition, and to 5 interventions - of which N-803 + Pembrolizumab is the first listed.
NCT03228667 names 20 study sites across 11 states, led by California, Florida, Missouri.
Frequently Asked Questions
What is clinical trial NCT03228667 about?
NCT03228667 is a clinical study titled "QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors". QUILT-3.055 is a Phase 2b, open-label, multicohort study investigating combination immunotherapies in patients with advanced solid tumors who have previously been treated with PD-1/PD-L1 checkpoint inhibitors. The study aims to evaluate the safety and efficacy of NAI (nogapendekin alfa inbakicept) i...
What is the current status of trial NCT03228667?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 40 participants. The study started on 2018-12-11. Estimated completion is 2030-12-31.
What conditions does trial NCT03228667 study?
This clinical trial studies the following conditions: Non-Small Cell Lung Cancer, Melanoma, Gastric Cancer, Cervical Cancer, Hepatocellular Carcinoma.
What interventions are being tested in trial NCT03228667?
The interventions under investigation include: N-803 + Pembrolizumab (DRUG), N-803 + Nivolumab (DRUG), N-803 + Atezolizumab (DRUG), N-803 + Avelumab (DRUG), N-803 + Durvalumab (DRUG).
Who is sponsoring clinical trial NCT03228667?
This trial is sponsored by ImmunityBio, which has 46 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03228667 being conducted?
This trial has 20 study locations across Alaska, Arkansas, California, Florida, Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03228667's enrollment target sits among peer trials
40 360th of 454 higher than 87 of 454 other Non-Small Cell Lung Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Non-Small Cell Lung Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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