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Kidney Cancer clinical trials
19 of 69 indexed Kidney Cancer trials are currently recruiting.
69 US clinical trials · 19 currently recruiting
Kidney Cancer is the subject of 69 registered US clinical trials on ClinicalTrials.gov, 19 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 42 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 6 of these trials.
The research picture
Kidney Cancer has 69 registered US clinical trials, 19 of them open to new participants right now, about 28% of the total.
- 19
- recruiting participants now
- 28%
- of trials open to enrollment
- 4
- in Phase 3–4 (later-stage)
- 6
- top sponsor: National Cancer Institute (NCI)
Active & Recent Trials
69 total, page 1 of 2
International REgistry of COnservative or Radical Treatment of Localized Kidney Tumors
Azienda Ospedaliero-Universitaria Careggi
NCT05363657
Collection of Serum and Tissue Samples From Patients With Biopsy-Proved or Suspected Malignant Disease
National Cancer Institute (NCI)
NCT00026884
Von Hippel-Lindau (VHL): Clinical Manifestations, Diagnosis, Management and Molecular Bases of Inherited Renal and Other Urologic Malignant Disorders
National Cancer Institute (NCI)
NCT00001238
Hereditary Leiomyomatosis Renal Cell Cancer - Study of the Genetic Cause and the Predisposition to Renal Cancer
National Cancer Institute (NCI)
NCT00050752
Improving Nutrition and Physical Activity for Cancer Survivors (Tools To Be Fit)
University of California, San Francisco
NCT05056077
Genetic Analysis of Birt Hogg-Dube Syndrome and Characterization of Predisposition to Kidney Cancer
National Cancer Institute (NCI)
NCT00033137
An Investigation of Kidney and Urothelial Tumor Metabolism in Patients Undergoing Surgical Resection and/or Biopsy
University of Texas Southwestern Medical Center
NCT04623502
Observational Basket Trial to Collect Tissue to Develop and Train a Live Tumor Diagnostic Platform
Elephas
NCT05520099
Preop Laxatives in Robotic Urologic Surgery
Chad R. Tracy
NCT05805436
Designing Visual Tools to Enhance Cancer Surgeon Decision-making
UNC Lineberger Comprehensive Cancer Center
NCT06965192
NSAID Use After Robotic Partial Nephrectomy
University of Miami
NCT05842044
Patient Navigation Program to Improve Clinical Trial Enrollment in Cancer Patients
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT06138067
A Study of VET3-TGI in Patients With Solid Tumors
KaliVir Immunotherapeutics
NCT06444815
CYTO Reductive Surgery in Kidney Cancer Plus Immunotherapy and Targeted Kinase Inhibition
Mark Stein
NCT04322955
Pre-NEOSHIFT-RCC: Neoadjuvant HIF-Inhibitor Immunotherapy in RCC
Dana-Farber Cancer Institute
NCT07397611
Study of Olaparib in Metastatic Renal Cell Carcinoma Patients With DNA Repair Gene Mutations
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT03786796
Neoadjuvant Pembrolizumab and Axitinib in Renal Cell Carcinoma With Inferior Vena Cava Tumor Thrombus
University of Colorado, Denver
NCT05969496
Brodalumab in the Treatment of Immune-Related Adverse Events
Brian Henick, MD
NCT06673329
A Novel Imaging Protocol in Use to Identify Lymph Nodes and Organs of Interest
Dana-Farber Cancer Institute
NCT05899361
Germline Alterations of Tumor Susceptibility Genes in New York Cancer Patients
Memorial Sloan Kettering Cancer Center
NCT00579514
Adapting Multiple Behavior Interventions That Effectively Improve Cancer Survivor Health Cancer Survivor Health
University of Alabama at Birmingham
NCT04000880
Reduction of Allogenic Blood Transfusion in Locally Advanced Kidney Cancer
Vanderbilt University Medical Center
NCT04922307
Sequential Two-agent Assessment in Renal Cell Carcinoma Therapy: The START Trial
M.D. Anderson Cancer Center
NCT01217931
Random Evaluation of Patients Who Have Had Laparoscopic Partial Nephrectomy
University of Chicago
NCT04120805
KidneyCare Cohort Study (KCC-S)
University of Utah
NCT06898632
Medtronic Hugo™ Robotic Assisted Surgery (RAS) System in Urologic Surgery (Expand URO)
Medtronic - MITG
NCT05696444
A Phase I, Open-Label, Multi-center Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD6244 (ARRY-142886)
AstraZeneca
NCT00600496
A Trial of Belzutifan (PT2977, MK-6482) in Combination With Cabozantinib in Patients With Clear Cell Renal Cell Carcinoma (ccRCC) (MK-6482-003)
Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
NCT03634540
A Phase 1, Dose-Escalation Trial of PT2385 Tablets In Patients With Advanced Clear Cell Renal Cell Carcinoma (MK-3795-001)
Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
NCT02293980
The HistoSonics Edison™ System for Treatment of Primary Solid Renal Tumors Using Histotripsy (#HOPE4KIDNEY)
HistoSonics
NCT05820087
Study of Durvalumab and Guadecitabine in Advanced Kidney Cancer
Ajjai Alva, MD
NCT03308396
Evaluating Safety and Biomarkers Using DK210 (EGFR) for Locally Advanced or Metastatic EGFR+ Tumors
DEKA Biosciences
NCT05704985
Integrated Actionable Aging Assessment for Cancer Patients Pilot
University of Colorado, Denver
NCT05871008
177LuPSMA in Renal Cell Carcinoma
Dana-Farber Cancer Institute
NCT06964958
NeoVax Plus Ipilimumab in Renal Cell Carcinoma
Patrick Ott, MD, PhD
NCT02950766
Perioperative Lenvatinib With Pembrolizumab in Patients With Locally Advanced Nonmetastatic Clear Cell Renal Cell Carcinoma
Emory University
NCT04393350
HERV-E TCR Transduced Autologous T Cells in People With Metastatic Clear Cell Renal Cell Carcinoma
National Heart, Lung, and Blood Institute (NHLBI)
NCT03354390
Study of Nivolumab in Combination With 177Lu-girentuximab for Kidney Cancer
Memorial Sloan Kettering Cancer Center
NCT05239533
Case-Control Study of Renal Cell Cancer Among Caucasions and African Americans in the United States
National Cancer Institute (NCI)
NCT00340457
Glutamic Acid in Reducing Nerve Damage Caused by Vincristine in Young Patients With Cancer
University of South Florida
NCT00369564
Chemotherapy With or Without Surgery, Radiation Therapy, or Stem Cell Transplantation in Treating Young Patients With Kidney Tumors
Children's Oncology Group
NCT00002610
A Prospective Post-Market Study to Evaluate the Clinical Utility of IRIS, a Three-dimensional (3-D) Anatomical Modeling Software for Pre-operative Surgical Planning and Intra-operative Navigation for Nephrectomy
Intuitive Surgical
NCT04329767
High-dose Bevacizumab in Advanced Renal Carcinoma Patients
SCRI Development Innovations
NCT00455975
A Phase 1/2, Open-label Study to Evaluate the Safety and Antitumor Activity of MEDI0680 (AMP-514) in Combination With Durvalumab Versus Nivolumab Monotherapy in Participants With Select Advanced Malignancies
MedImmune
NCT02118337
Sunitinib and Erlotinib in Treating Patients With Unresectable or Metastatic Kidney Cancer
OHSU Knight Cancer Institute
NCT00425386
Sunitinib Scheduling in Metastatic Renal Cell Carcinoma (mRCC)
M.D. Anderson Cancer Center
NCT02060370
Cyclophosphamide Plus Vaccine Therapy in Treating Patients With Advanced Cancer
St. Vincent Medical Center - Los Angeles
NCT00002475
Neoadjuvant Axitinib in Locally Advanced Renal Cell Carcinoma (RCC)
M.D. Anderson Cancer Center
NCT01263769
Neoadjuvant MEDI 4736 +/- Tremelimumab in Locally Advanced Renal Cell Carcinoma
Moshe Ornstein
NCT02762006
SBRT (Stereotactic Body Radiation Therapy) in Combination With Nivolumab/Ipilimumab in Renal Cell Carcinoma (RCC) / Kidney Cancer Patients
University of Texas Southwestern Medical Center
NCT03065179
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 14 |
| Phase 2 | 28 |
| Phase 3 | 2 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Kidney Cancer Trial Landscape
69 indexed Kidney Cancer studies · 19 recruiting (28%).
Phase mix: 4 late (III/IV) vs 42 early (I/II).
Top sponsor: National Cancer Institute (NCI) (6 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Kidney Cancer?
PlainTrial tracks 69 US clinical trials for Kidney Cancer, of which 19 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Kidney Cancer?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.