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NCT05239533 · ClinicalTrials.gov registry record · Phase 2
Study of Nivolumab in Combination With 177Lu-girentuximab for Kidney Cancer
A Phase 2 study of Kidney Cancer and Clear Cell Renal Cell Carcinoma, sponsored by Memorial Sloan Kettering Cancer Center.
- Active
- Registry status
- Phase 2
- Development phase
- 9
- Enrollment target
- 7
- Study locations
NCT05239533: Active Phase 2 study of Kidney Cancer and Clear Cell Renal Cell Carcinoma, sponsored by Memorial Sloan Kettering Cancer Center.
NCT05239533 is a Phase 2 study of Kidney Cancer and Clear Cell Renal Cell Carcinoma that is active but no longer recruiting, run by Memorial Sloan Kettering Cancer Center. The registered enrollment target is 9 participants, below the 880-participant average among 60 other Kidney Cancer trials with a reported enrollment target (99% lower). The trial reports 7 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05239533, a Phase 2 study of Kidney Cancer and Clear Cell Renal Cell Carcinoma, is active but no longer recruiting, sponsored by Memorial Sloan Kettering Cancer Center.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 9 participants
- Enrollment target
- 7
- Study locations
Study Summary
The purpose of this study is to see if the combination of 177Lu-girentuximab and nivolumab is a safe and effective treatment for advanced clear cell renal cell carcinoma/ccRCC that has the CAIX protein.
Primary Outcome
To determine the maximal tolerated dose (MTD) of 177Lu-girentuximab when given in combination with nivolumab (safety lead-in)
Conditions Studied
Interventions
- DRUG Nivolumab
- DRUG 177Lu-labeled-girentuximab
- DIAGNOSTIC_TEST 89Zr-girentuximab PET/CT
- DIAGNOSTIC_TEST 177Lu whole body (WB) planar and SPECT/CT scans
Study Locations (7)
New York
- Memorial Sloan Kettering Suffolk-Commack (Limited Protocol Activities) - Commack
- Memorial Sloan Kettering Westchester (Limited Protocol Activites) - Harrison
- Memorial Sloan Kettering Cancer Center (All Protocol Activities) - New York
- Memorial Sloan Kettering Nassau (Limited Protocol Activites) - Uniondale
New Jersey
- Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities) - Basking Ridge
- Memorial Sloan Kettering Monmouth (Limited Protocol Activities) - Middletown
- Memorial Sloan Kettering Bergen (Limited Protocol Activities) - Montvale
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 9 participants |
| Start Date | 2022-02-16 |
| Est. Completion | 2027-03 |
| Phase | Phase 2 |
What the registry record for NCT05239533 still lists
NCT05239533 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 9 participants, a relatively small participant target, below the 880-participant average among 60 other Kidney Cancer trials with a reported enrollment target (99% lower).
The record links to 3 conditions, with Kidney Cancer appearing as the primary indexed condition, and to 4 interventions - of which Nivolumab is the first listed.
NCT05239533 lists 7 locations in 2 states (New York, New Jersey).
Frequently Asked Questions
What is clinical trial NCT05239533 about?
NCT05239533 is a clinical study titled "Study of Nivolumab in Combination With 177Lu-girentuximab for Kidney Cancer". The purpose of this study is to see if the combination of 177Lu-girentuximab and nivolumab is a safe and effective treatment for advanced clear cell renal cell carcinoma/ccRCC that has the CAIX protein.
What is the current status of trial NCT05239533?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 9 participants. The study started on 2022-02-16. Estimated completion is 2027-03.
What conditions does trial NCT05239533 study?
This clinical trial studies the following conditions: Kidney Cancer, Clear Cell Renal Cell Carcinoma, Advanced Renal Cell Carcinoma.
What interventions are being tested in trial NCT05239533?
The interventions under investigation include: Nivolumab (DRUG), 177Lu-labeled-girentuximab (DRUG), 89Zr-girentuximab PET/CT (DIAGNOSTIC_TEST), 177Lu whole body (WB) planar and SPECT/CT scans (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT05239533?
This trial is sponsored by Memorial Sloan Kettering Cancer Center, which has 1,884 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05239533 being conducted?
This trial has 7 study locations across New Jersey, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT05239533's enrollment target sits among peer trials
9 59th of 60 higher than 1 of 60 other Kidney Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Kidney Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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