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NCT00033137 · ClinicalTrials.gov registry record
Genetic Analysis of Birt Hogg-Dube Syndrome and Characterization of Predisposition to Kidney Cancer
A clinical trial of Kidney Cancer and Kidney Neoplasms, sponsored by National Cancer Institute (NCI).
- Recruiting
- Registry status
- 950
- Enrollment target
- 1
- Study location
NCT00033137 is a study of Kidney Cancer and Kidney Neoplasms that is actively recruiting participants, run by National Cancer Institute (NCI). The registered enrollment target is 950 participants, above the 865-participant average among 60 other Kidney Cancer trials with a reported enrollment target (10% higher). The trial reports 1 study location across 1 state.
The verdict
NCT00033137, a study of Kidney Cancer and Kidney Neoplasms, is actively recruiting participants, sponsored by National Cancer Institute (NCI).
- RECRUITING
- Registry status
- 950 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will investigate the genetic cause of Birt Hogg-Dube (BHD) syndrome and the relationship of this disorder to kidney cancer. BHD is a rare inherited condition characterized by papules, or bumps-benign tumors involving hair follicles-on the head and neck. People with BHD are at increased risk of developing kidney cancer. Scientists have identified the chromosome (strand of genetic material in the cell nucleus) that contains the BHD gene and the region of the gene on the chromosome. This study will try to learn more about: * The characteristics and type of kidney tumors associated with BHD * The risk of kidney cancer in people with BHD * Whether more than one gene causes BHD * The genetic mutations (changes) responsible for BHD Patients with known or suspected Birt Hogg-Dube syndrome, and their family members, may be eligible for this study. Candidates will be screened with a family history and review of medical records, including pathology reports for tumors, and films of computed tomography (CT) and magnetic resonance imaging (MRI) scans. Participants may undergo various tests and procedures, including the following: * Physical examination * Review of personal and family history with a cancer doctor, cancer nurses, kidney surgeon, and genetic counselor * Chest and other x-rays * Ultrasound (imaging study using sound waves) * MRI (imaging study using radiowaves and a magnetic field) * CT scans of the chest and abdomen (imaging studies using radiation) * Blood tests for blood chemistries and genetic testing * Skin evaluation, including a skin biopsy (surgical removal of a small skin tissue sample for microscopic evaluation) * Cheek swab or mouthwash to collect cells for genetic analysis * Lung function studies * Medical photography of skin lesions These tests will be done on an outpatient basis in either one day or over 3 to 4 days. When the studies are complete, participants will receive counseling about the findings and recommendations. Patients with
Conditions Studied
Study Locations (1)
Maryland
- National Institutes of Health Clinical Center - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 950 participants |
| Start Date | 2002-05-13 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00033137
The ClinicalTrials.gov registry entry for NCT00033137 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 950 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 865-participant average among 60 other Kidney Cancer trials with a reported enrollment target (10% higher). The listed sponsor is National Cancer Institute (NCI), which has 3,257 total studies on file at ClinicalTrials.gov.
The record links to 4 conditions, with Kidney Cancer appearing as the primary indexed condition, and to 0 interventions.
NCT00033137 reports 1 study location spanning 1 distinct geographic area - top geographies include Maryland.
Frequently Asked Questions
What is clinical trial NCT00033137 about?
NCT00033137 is a clinical study titled "Genetic Analysis of Birt Hogg-Dube Syndrome and Characterization of Predisposition to Kidney Cancer". This study will investigate the genetic cause of Birt Hogg-Dube (BHD) syndrome and the relationship of this disorder to kidney cancer. BHD is a rare inherited condition characterized by papules, or bumps-benign tumors involving hair follicles-on the head and neck. People with BHD are at increased ri...
What is the current status of trial NCT00033137?
This trial is currently recruiting. The enrollment target is 950 participants. The study started on 2002-05-13.
What conditions does trial NCT00033137 study?
This clinical trial studies the following conditions: Kidney Cancer, Kidney Neoplasms, Pneumothorax, FLCN Protein, Human.
Who is sponsoring clinical trial NCT00033137?
This trial is sponsored by National Cancer Institute (NCI), which has 3,257 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00033137 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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