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COMPLETED Phase 3

Chemotherapy With or Without Surgery, Radiation Therapy, or Stem Cell Transplantation in Treating Young Patients With Kidney Tumors

NCT00002610 · View on ClinicalTrials.gov ↗

Study Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells. It is not yet known which therapy regimen is most effective for treating patients with kidney tumors. PURPOSE: Phase III trial to compare the effectiveness of chemotherapy with or without radiation therapy, surgery, and/or peripheral stem cell or bone marrow transplantation in treating young patients with kidney tumors.

Conditions Studied

Interventions

  • DRUG carboplatin
  • DRUG cyclophosphamide
  • BIOLOGICAL filgrastim
  • DRUG doxorubicin hydrochloride
  • BIOLOGICAL dactinomycin

Study Locations (20)

California

  • Southern California Permanente Medical Group — Downey
  • City of Hope Comprehensive Cancer Center — Duarte
  • Rebecca and John Moores UCSD Cancer Center — La Jolla
  • Loma Linda University Medical Center — Loma Linda
  • Jonathan Jaques Children's Cancer Center — Long Beach
  • Children's Hospital Los Angeles — Los Angeles
  • Cedars-Sinai Medical Center — Los Angeles
  • Jonsson Comprehensive Cancer Center, UCLA — Los Angeles
  • Children's Hospital Central California — Madera
  • Children's Hospital of Oakland — Oakland
  • Chao Family Comprehensive Cancer Center — Orange
  • Children's Hospital of Orange County — Orange
  • Lucile Packard Children's Hospital at Stanford — Palo Alto
  • Sutter Cancer Center — Sacramento
  • University of California Davis Medical Center — Sacramento

Alabama

  • University of Alabama at Birmingham Comprehensive Cancer Center — Birmingham
  • University of South Alabama Medical Center — Mobile

Arizona

  • Phoenix Children's Hospital — Phoenix
  • Arizona Cancer Center — Tucson

Arkansas

  • University of Arkansas for Medical Sciences — Little Rock

Trial Details

FieldValue
Enrollment Target 203 participants
Start Date 1996-01
Est. Completion 2006-02
Phase Phase 3

Sponsor

Children's Oncology Group

318 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00002610

The ClinicalTrials.gov registry entry for NCT00002610 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 203 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Children's Oncology Group, which has 318 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Kidney Cancer appearing as the primary indexed condition, and to 5 interventions — of which carboplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00002610 reports 20 study locations spanning 4 distinct geographic areas — top geographies include California, Alabama, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00002610 about?

NCT00002610 is a clinical study titled "Chemotherapy With or Without Surgery, Radiation Therapy, or Stem Cell Transplantation in Treating Young Patients With Kidney Tumors". RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of chemo...

What is the current status of trial NCT00002610?

This trial is currently completed. It is a Phase 3 study. The enrollment target is 203 participants. The study started on 1996-01. Estimated completion is 2006-02.

What conditions does trial NCT00002610 study?

This clinical trial studies the following conditions: Kidney Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00002610?

The interventions under investigation include: carboplatin (DRUG), cyclophosphamide (DRUG), filgrastim (BIOLOGICAL), doxorubicin hydrochloride (DRUG), dactinomycin (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00002610?

This trial is sponsored by Children's Oncology Group, which has 318 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00002610 being conducted?

This trial has 20 study locations across Alabama, Arizona, Arkansas, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial