Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Inflammation

Open-data reference.

133 US clinical trials · 51 currently recruiting

Active & Recent Trials

RECRUITING Phase 3 6,150 participants

Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk

Population Health Research Institute

NCT04774159

RECRUITING 4,200 participants

Biomarkers in Infection

Beth Israel Deaconess Medical Center

NCT02545478

RECRUITING 2,000 participants

Natural History of the Human Biological Response to Environmental Exposure and Injury

National Institute of Environmental Health Sciences (NIEHS)

NCT04888923

RECRUITING 750 participants

Immune Cell Response to Stimuli

National Institute of Environmental Health Sciences (NIEHS)

NCT00397280

RECRUITING NA 450 participants

Impacts of Cash Transfers on Child Neurodevelopment (Auxilio Brasil)

New York State Psychiatric Institute

NCT05477901

RECRUITING 400 participants

Diagnosis and Management of Inflammatory and Infectious Diseases

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00557726

RECRUITING 400 participants

Immunoinflammatory Response in Post Cardiac Arrest Syndrome (PCAS)

MaineHealth

NCT02664831

RECRUITING NA 342 participants

Improving Maternal Sleep and Mental Health

University of Colorado, Colorado Springs

NCT06544941

RECRUITING NA 300 participants

The Impact of a Race-Based Stress Reduction Intervention

Loyola University

NCT05902741

RECRUITING NA 276 participants

Wellness App for Sleep Disturbance in Hematological Cancer Patients

The University of Texas Health Science Center at San Antonio

NCT05294991

RECRUITING NA 260 participants

Partners in Children's Health (CSN): A Randomized Trial of an Attachment Based Intervention

University of Maryland, Baltimore

NCT06002685

RECRUITING Phase 2 240 participants

Focused Orticumab Research for Treating Inflammation in Coronary Arteries

Abcentra

NCT06927739

RECRUITING NA 240 participants

UCLA REST Study (REsearch on Sleep Techniques)

University of California, Los Angeles

NCT05576090

RECRUITING Phase 2 225 participants

Anti-retroviral Therapy, Medications for Opioid Use Disorder, Opioids and HIV Infection - Study 1

University of Pennsylvania

NCT04480554

RECRUITING NA 220 participants

Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury

Wake Forest University Health Sciences

NCT04810858

RECRUITING NA 220 participants

Synbiotic to Attenuate Resorption of the Skeleton

Hebrew SeniorLife

NCT06389539

RECRUITING Phase 2 216 participants

Modulating Exercise Dosage to Improve Concussion Recovery

University of Colorado, Denver

NCT05434130

RECRUITING NA 180 participants

Reducing Metabolic Dysregulation in Dyads

University of South Carolina

NCT06117241

RECRUITING NA 180 participants

Stress Phenotypes and Preterm Birth

Columbia University

NCT05229666

RECRUITING NA 150 participants

Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT)

Florida International University

NCT05136703

RECRUITING NA 120 participants

Gut Microbiota-dependent Health Impacts of Haskap Berries

Montana State University

NCT06546020

RECRUITING Phase 2 118 participants

Reducing Frailty for Older Cancer Survivors Using Supplements II

University of Rochester

NCT06068543

RECRUITING 117 participants

Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D)

Washington University School of Medicine

NCT05277558

RECRUITING NA 100 participants

Reducing Suicide Risk Among Aging Caregivers of Persons With AD/ADRD

Texas Tech University

NCT06055322

RECRUITING 100 participants

Relationship of Inflammation and Pulmonary Function to Fungal Translocation in HIV

University of Pittsburgh

NCT05502653

RECRUITING Phase 2 100 participants

Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab

Massachusetts General Hospital

NCT06136546

RECRUITING Phase 1 90 participants

Novel Approaches for Improving Vascular Function in Veterans With HFpEF

VA Office of Research and Development

NCT06312748

RECRUITING 80 participants

The Impact of Renal Transplant on Coronary Microvascular Function Among Patients With Advanced Chronic Kidney Disease

Brigham and Women's Hospital

NCT07222683

RECRUITING NA 75 participants

Cognitive Remediation

Cutter Lindbergh

NCT07171450

RECRUITING NA 70 participants

The Iowa ACEs and Sleep Cohort and Manipulating Sleep in Young Adults With ACEs Studies

Nathaniel Jenkins

NCT06454344

RECRUITING Phase 2 64 participants

Passive Stretching in Peripheral Arterial Disease Patients

University of Wisconsin, La Crosse

NCT06420752

RECRUITING Phase 2 60 participants

Efficacy of LoDoCo in Improving Exercise Capacity Among Patients With HFpEF and Inflammation

University of Texas Southwestern Medical Center

NCT06130059

RECRUITING NA 50 participants

Trans-Auricular Stimulation for Postoperative Inflammation in Spine Surgery

Alexander T. Yahanda

NCT07218133

RECRUITING NA 46 participants

The Impact of Biophoton Therapy on Self-Grown Stem Cells

First Institute of All Medicines

NCT06855459

RECRUITING Phase 2 40 participants

Clinical Trial of the Seaweed Supplement Fucoidan in Survivors of Cancer

University of Rochester

NCT06295588

RECRUITING NA 40 participants

Prebiotic Effects of California Grapes on Gut Health and Cardiometabolic Health in Overweight Men and Women

University of California, Davis

NCT06544954

RECRUITING NA 36 participants

The Effect of Mindfulness on Vascular Inflammation in Stable Coronary Disease

Massachusetts General Hospital

NCT04505865

RECRUITING 34 participants

Oxidative Stress and Inflammatory Biomarkers in Gaucher Disease

University of Minnesota

NCT02437396

RECRUITING Phase 4 32 participants

Skin Barrier Function and Inflammation in Aging: The BIA Study

University of California, San Francis

NCT06750653

RECRUITING NA 30 participants

Ketone Ester And Salt (KEAS) in Older Adults

Indiana University

NCT06868719

RECRUITING NA 30 participants

Evaluating Whether Hyperbaric Oxygen Therapy Can Improve VO₂-Max and Reduce Inflammation Markers in Healthy Adults Ages 30-60.

University of Texas at Austin

NCT07361861

RECRUITING NA 30 participants

Impact of NMES and HPRO on Recovery After SAH- Pilot Study

University of Maryland, Baltimore

NCT03201094

RECRUITING NA 30 participants

Pilot Study Evaluating the Impact of Stress Reduction on Atherosclerotic : Heart and Mind Study

Massachusetts General Hospital

NCT04496947

RECRUITING NA 30 participants

Impact of Haskap Berries on Recovery From High Intensity Resistance Training

Montana State University

NCT07344727

RECRUITING NA 30 participants

Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Prediabetes

Georgia State University

NCT06735651

RECRUITING NA 28 participants

Effects of Freeze-dried Grape Powder on Immune Profiles in Healthy Aging Adults

University of Connecticut

NCT07079982

RECRUITING NA 25 participants

Mango Intake and Gut and Cardiometabolic Health in Hispanic/Latino Adolescents

University of California, Davis

NCT07125001

RECRUITING Early Phase 1 24 participants

Role of Inflammation in Vascular Phenotype Associated With E-cigarette Use

University of Iowa

NCT06489249

RECRUITING NA 20 participants

Effects of Daily Beef Intake, as a Component of a Heart-Healthy Diet on Cellular Zinc

University of California, Davis

NCT05236374

RECRUITING 13 participants

Regulation of Inflammatory Genes in Psoriasis

University of Alabama at Birmingham

NCT03125655

RECRUITING Phase 1 12 participants

Safety, Tolerability, and Distribution of Laquinimod Eye Drops : The LION Study

Quan Dong Nguyen

NCT06161415

ACTIVE NOT RECRUITING Phase 3 6,200 participants

ZEUS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Cardiovascular Disease, Chronic Kidney Disease and Inflammation

Novo Nordisk A/S

NCT05021835

ACTIVE NOT RECRUITING NA 135 participants

Maternal & Offspring Microbiome Study

Stanford University

NCT05123612

ACTIVE NOT RECRUITING NA 120 participants

IGNITE Firefighters' Health

Stanford University

NCT06567561

ACTIVE NOT RECRUITING NA 80 participants

Almonds to Improve Gut Health and Decrease Inflammation

Oregon State University

NCT05790564

ACTIVE NOT RECRUITING Phase 2 80 participants

Specialized Pro-resolving Lipid Mediators and Treatment Resistant Depression

Massachusetts General Hospital

NCT05774665

ACTIVE NOT RECRUITING Early Phase 1 66 participants

Sleep and Inflammatory Resolution Pathway

Beth Israel Deaconess Medical Center

NCT03377543

ACTIVE NOT RECRUITING NA 66 participants

Understanding Dose Related Effects of Strawberry

Clinical Nutrition Research Center, Illinois Institute of Technology

NCT06173765

ACTIVE NOT RECRUITING NA 65 participants

Assessing Gut Microbiota Mediated Health Outcomes of Whole Wheat and Its Major Bioactive Components

Ohio State University

NCT05318183

ACTIVE NOT RECRUITING NA 31 participants

The Effects of Fresh Mango Consumption on Cardiometabolic Outcomes in Free-living Individuals With Prediabetes

Loma Linda University

NCT06159543

ACTIVE NOT RECRUITING 30 participants

Cardiovascular Structure and Function in the Mucopolysaccharidoses

Children's Hospital of Orange County

NCT05063435

ACTIVE NOT RECRUITING Phase 2 29 participants

Improving Physical Function in Older Adults Using an Anti-inflammation Drug: The RIGHT Study

Anne B. Newman

NCT05727384

ACTIVE NOT RECRUITING NA 25 participants

Plant-based Diet for Kidney Transplant Recipients

George Washington University

NCT06186843

ACTIVE NOT RECRUITING Phase 1 20 participants

Salt-Sensitivity and Immunity Cell Activation

Vanderbilt University Medical Center

NCT03753204

ACTIVE NOT RECRUITING Early Phase 1 10 participants

Induction of Gut Permeability by an Oral Vaccine

USDA, Western Human Nutrition Research Center

NCT04083950

COMPLETED 3,402 participants

Michigan Medicine COVID-19 Cohort: Clinical Characteristics, Inflammatory Markers and Outcomes of Patients Hospitalized for COVID-19

University of Michigan

NCT04706533

COMPLETED 2,500 participants

Inflammation and Nutritional Parameters in Hemodialysis Patients Using Reprocessed Dialyzers

Fresenius Medical Care North America

NCT00440908

COMPLETED Phase 3 452 participants

Effect of Vitamin K on Age-Related Bone Loss and Vascular Calcification

National Institute on Aging (NIA)

NCT00183001

COMPLETED Phase 3 407 participants

Evaluation of Loteprednol Etabonate Versus Vehicle for the Treatment of Inflammation and Pain Following Cataract Surgery

Bausch & Lomb Incorporated

NCT01060072

COMPLETED Phase 3 369 participants

Mapracorat Ophthalmic Suspension, 3% for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery

Bausch & Lomb Incorporated

NCT01591161

COMPLETED Phase 3 339 participants

Efficacy and Safety of XG-102 in Reduction of Post-cataract Surgery Intraocular Inflammation

Xigen

NCT02235272

COMPLETED 320 participants

Medicinal Plant Use for Treating Inflammation Among Dominicans in New York City and the Dominican Republic

New York Botanical Garden

NCT00109980

COMPLETED 310 participants

Blood Markers of Inflammation, Blood Clotting and Blood Vessel Function in HIV-infected Adults

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00776412

COMPLETED Phase 2 289 participants

The ENRGISE (ENabling Reduction of Low-Grade Inflammation in SEniors) Pilot Study

University of Florida

NCT02676466

COMPLETED NA 287 participants

The Effect of a Nutritional Supplement Product Containing Cactus Fruit Juice (Nopalea) on C-Reactive Protein

Mark Mattie

NCT01881178

COMPLETED Phase 3 248 participants

A Study of Ketorolac for the Treatment of Inflammation and Pain Associated With Cataract Surgery

Allergan

NCT00524264

COMPLETED 178 participants

Study of the Effect of SNPs in p53 and p53 Response Elements on the Inflammatory Response to DNA Damage

National Institute of Environmental Health Sciences (NIEHS)

NCT01143519

COMPLETED NA 175 participants

Salivary Inflammatory Biomarkers: Predictors & Comparative Effects of Sonicare/Elite-Flexcare in Stages of Perio Disease

University of North Carolina, Chapel Hill

NCT02187185

COMPLETED 164 participants

Vaccine Efficacy in Diabetic and Elderly Patients

Tulane University

NCT02675608

COMPLETED Phase 2 152 participants

Colchicine to Suppress Inflammation and Improve Insulin Resistance in Adults and Adolescents With Obesity

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NCT05017571

COMPLETED NA 117 participants

Effect of Anatabine on Elevated Blood Levels of C-reactive Protein

Roskamp Institute

NCT01607619

COMPLETED Phase 4 108 participants

Systemic Immunomodulatory Effects and Pharmacogenetics of Atorvastatin in Early Atherosclerosis

University of Florida

NCT00361283

COMPLETED Phase 4 108 participants

Suvorexant on Sleep Disturbance in Patients With Chronic Insomnia and Suboptimally Controlled Type 2 Diabetes

Massachusetts General Hospital

NCT03818581

COMPLETED NA 100 participants

Vegan vs AHA Diet on Inflammation and Glucometabolic Profile in Patients With CAD

NYU Langone Health

NCT02135939

COMPLETED NA 96 participants

Vitamin D Repletion in Coronary Artery Disease

Seth I. Sokol, M.D.

NCT01570309

COMPLETED NA 87 participants

Stress Reduction Training to Improve Sleep Quality, Stress Physiology & Cardiovascular Disease (CVD) Risk Markers

Duke University

NCT01343810

COMPLETED 77 participants

Alcohol and Cannabis Co-Use and the Gut-Brain Axis

University of Colorado, Denver

NCT04998006

COMPLETED NA 72 participants

The Impact of Low-fat and Full-fat Dairy Consumption on Glucose Homeostasis (DAIRY Study)

Fred Hutchinson Cancer Center

NCT02663544

COMPLETED NA 71 participants

Effect of a Spice Blend on Cardiovascular Risk Factors and Diet Satisfaction

Penn State University

NCT03064932

COMPLETED NA 70 participants

Tart Cherry Supplementation & Gut Microbiome and Inflammation

Ohio University

NCT04467372

COMPLETED 68 participants

Analysis of Microalbuminuria and Markers of Inflammation and Oxidative Stress in Adolescents of Different Ethnic Backgrounds

University of California, Davis

NCT00616707

COMPLETED Early Phase 1 65 participants

Effect of High-Legume Diet on Colorectal Cancer Risk

National Cancer Institute (NCI)

NCT00339469

COMPLETED 64 participants

A Study Evaluating the Association of Inflammation With Hemodialysis Access Type

Montefiore Medical Center

NCT01011985

COMPLETED NA 61 participants

Effect of Almonds on Immune Strength and Response to Flu Vaccination in Overweight Older Men and Postmenopausal Women: A Randomized Controlled Study

Loma Linda University

NCT05031663

COMPLETED 59 participants

Study on Immunopathogenesis in HIV and Hepatitis C Coinfection

Rush University Medical Center

NCT01296529

COMPLETED Phase 2 56 participants

Safety/Efficacy of Nepafenac Punctal Plug Delivery System Compared to Placebo to Control Ocular Pain/Inflammation After Cataract

Mati Therapeutics

NCT03496467

COMPLETED Phase 2 55 participants

Antiplatelet Therapy in HIV

NYU Langone Health

NCT02559414

COMPLETED NA 52 participants

Zinc Supplementation and Cardiovascular Risk in HIV

Grace McComsey

NCT02856269

COMPLETED NA 50 participants

The Impact of a Polyphenol-Rich Supplement on Epigenetic and Cellular Markers of Immune Age

Big Bold Health, PBC

NCT05234203

COMPLETED NA 48 participants

Bioequivalency Study of Meloxicam Tablets Under Fed Conditions

Roxane Laboratories

NCT00601887

Phase Distribution

PhaseTrial count
Early Phase 1 10
Phase 2 16
Phase 3 8
Phase 4 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Inflammation Trial Landscape

ClinicalTrials.gov lists 133 US studies indexed under Inflammation, and 51 of those are currently open to recruitment — roughly 38% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Inflammation shows 13 late-stage studies (Phase 3 and Phase 4 combined) alongside 26 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Inflammation is led by Massachusetts General Hospital with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Inflammation?

PlainTrial tracks 133 US clinical trials for Inflammation, of which 51 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Inflammation?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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