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ClinicalTrials.gov 51 recruiting now official registry

Inflammation clinical trials

51 of 133 indexed Inflammation trials are currently recruiting.

133 US clinical trials · 51 currently recruiting

Inflammation is the subject of 133 registered US clinical trials on ClinicalTrials.gov, 51 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 26 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 6 of these trials.

The research picture

Inflammation has 133 registered US clinical trials, 51 of them open to new participants right now, about 38% of the total.

51
recruiting participants now
38%
of trials open to enrollment
13
in Phase 3–4 (later-stage)
6
top sponsor: Massachusetts General Hospital
Phase 110Phase 216Phase 38Phase 45

Active & Recent Trials

133 total, page 2 of 3

RECRUITING Phase 1 12 participants

Safety, Tolerability, and Distribution of Laquinimod Eye Drops : The LION Study

Quan Dong Nguyen

NCT06161415

ACTIVE NOT RECRUITING Phase 3 6,200 participants

ZEUS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Cardiovascular Disease, Chronic Kidney Disease and Inflammation

Novo Nordisk A/S

NCT05021835

ACTIVE NOT RECRUITING NA 135 participants

Maternal & Offspring Microbiome Study

Stanford University

NCT05123612

ACTIVE NOT RECRUITING NA 120 participants

IGNITE Firefighters' Health

Stanford University

NCT06567561

ACTIVE NOT RECRUITING NA 80 participants

Almonds to Improve Gut Health and Decrease Inflammation

Oregon State University

NCT05790564

ACTIVE NOT RECRUITING Phase 2 80 participants

Specialized Pro-resolving Lipid Mediators and Treatment Resistant Depression

Massachusetts General Hospital

NCT05774665

ACTIVE NOT RECRUITING Early Phase 1 66 participants

Sleep and Inflammatory Resolution Pathway

Beth Israel Deaconess Medical Center

NCT03377543

ACTIVE NOT RECRUITING NA 66 participants

Understanding Dose Related Effects of Strawberry

Clinical Nutrition Research Center, Illinois Institute of Technology

NCT06173765

ACTIVE NOT RECRUITING NA 65 participants

Assessing Gut Microbiota Mediated Health Outcomes of Whole Wheat and Its Major Bioactive Components

Ohio State University

NCT05318183

ACTIVE NOT RECRUITING NA 31 participants

The Effects of Fresh Mango Consumption on Cardiometabolic Outcomes in Free-living Individuals With Prediabetes

Loma Linda University

NCT06159543

ACTIVE NOT RECRUITING 30 participants

Cardiovascular Structure and Function in the Mucopolysaccharidoses

Children's Hospital of Orange County

NCT05063435

ACTIVE NOT RECRUITING Phase 2 29 participants

Improving Physical Function in Older Adults Using an Anti-inflammation Drug: The RIGHT Study

Anne B. Newman

NCT05727384

ACTIVE NOT RECRUITING NA 25 participants

Plant-based Diet for Kidney Transplant Recipients

George Washington University

NCT06186843

ACTIVE NOT RECRUITING Phase 1 20 participants

Salt-Sensitivity and Immunity Cell Activation

Vanderbilt University Medical Center

NCT03753204

ACTIVE NOT RECRUITING Early Phase 1 10 participants

Induction of Gut Permeability by an Oral Vaccine

USDA, Western Human Nutrition Research Center

NCT04083950

COMPLETED 3,402 participants

Michigan Medicine COVID-19 Cohort: Clinical Characteristics, Inflammatory Markers and Outcomes of Patients Hospitalized for COVID-19

University of Michigan

NCT04706533

COMPLETED 2,500 participants

Inflammation and Nutritional Parameters in Hemodialysis Patients Using Reprocessed Dialyzers

Fresenius Medical Care North America

NCT00440908

COMPLETED Phase 3 452 participants

Effect of Vitamin K on Age-Related Bone Loss and Vascular Calcification

National Institute on Aging (NIA)

NCT00183001

COMPLETED Phase 3 407 participants

Evaluation of Loteprednol Etabonate Versus Vehicle for the Treatment of Inflammation and Pain Following Cataract Surgery

Bausch & Lomb Incorporated

NCT01060072

COMPLETED Phase 3 369 participants

Mapracorat Ophthalmic Suspension, 3% for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery

Bausch & Lomb Incorporated

NCT01591161

COMPLETED Phase 3 339 participants

Efficacy and Safety of XG-102 in Reduction of Post-cataract Surgery Intraocular Inflammation

Xigen

NCT02235272

COMPLETED 320 participants

Medicinal Plant Use for Treating Inflammation Among Dominicans in New York City and the Dominican Republic

New York Botanical Garden

NCT00109980

COMPLETED 310 participants

Blood Markers of Inflammation, Blood Clotting and Blood Vessel Function in HIV-infected Adults

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00776412

COMPLETED Phase 2 289 participants

The ENRGISE (ENabling Reduction of Low-Grade Inflammation in SEniors) Pilot Study

University of Florida

NCT02676466

COMPLETED NA 287 participants

The Effect of a Nutritional Supplement Product Containing Cactus Fruit Juice (Nopalea) on C-Reactive Protein

Mark Mattie

NCT01881178

COMPLETED Phase 3 248 participants

A Study of Ketorolac for the Treatment of Inflammation and Pain Associated With Cataract Surgery

Allergan

NCT00524264

COMPLETED 178 participants

Study of the Effect of SNPs in p53 and p53 Response Elements on the Inflammatory Response to DNA Damage

National Institute of Environmental Health Sciences (NIEHS)

NCT01143519

COMPLETED NA 175 participants

Salivary Inflammatory Biomarkers: Predictors & Comparative Effects of Sonicare/Elite-Flexcare in Stages of Perio Disease

University of North Carolina, Chapel Hill

NCT02187185

COMPLETED 164 participants

Vaccine Efficacy in Diabetic and Elderly Patients

Tulane University

NCT02675608

COMPLETED Phase 2 152 participants

Colchicine to Suppress Inflammation and Improve Insulin Resistance in Adults and Adolescents With Obesity

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NCT05017571

COMPLETED NA 117 participants

Effect of Anatabine on Elevated Blood Levels of C-reactive Protein

Roskamp Institute

NCT01607619

COMPLETED Phase 4 108 participants

Systemic Immunomodulatory Effects and Pharmacogenetics of Atorvastatin in Early Atherosclerosis

University of Florida

NCT00361283

COMPLETED Phase 4 108 participants

Suvorexant on Sleep Disturbance in Patients With Chronic Insomnia and Suboptimally Controlled Type 2 Diabetes

Massachusetts General Hospital

NCT03818581

COMPLETED NA 100 participants

Vegan vs AHA Diet on Inflammation and Glucometabolic Profile in Patients With CAD

NYU Langone Health

NCT02135939

COMPLETED NA 96 participants

Vitamin D Repletion in Coronary Artery Disease

Seth I. Sokol, M.D.

NCT01570309

COMPLETED NA 87 participants

Stress Reduction Training to Improve Sleep Quality, Stress Physiology & Cardiovascular Disease (CVD) Risk Markers

Duke University

NCT01343810

COMPLETED 77 participants

Alcohol and Cannabis Co-Use and the Gut-Brain Axis

University of Colorado, Denver

NCT04998006

COMPLETED NA 72 participants

The Impact of Low-fat and Full-fat Dairy Consumption on Glucose Homeostasis (DAIRY Study)

Fred Hutchinson Cancer Center

NCT02663544

COMPLETED NA 71 participants

Effect of a Spice Blend on Cardiovascular Risk Factors and Diet Satisfaction

Penn State University

NCT03064932

COMPLETED NA 70 participants

Tart Cherry Supplementation & Gut Microbiome and Inflammation

Ohio University

NCT04467372

COMPLETED 68 participants

Analysis of Microalbuminuria and Markers of Inflammation and Oxidative Stress in Adolescents of Different Ethnic Backgrounds

University of California, Davis

NCT00616707

COMPLETED Early Phase 1 65 participants

Effect of High-Legume Diet on Colorectal Cancer Risk

National Cancer Institute (NCI)

NCT00339469

COMPLETED 64 participants

A Study Evaluating the Association of Inflammation With Hemodialysis Access Type

Montefiore Medical Center

NCT01011985

COMPLETED NA 61 participants

Effect of Almonds on Immune Strength and Response to Flu Vaccination in Overweight Older Men and Postmenopausal Women: A Randomized Controlled Study

Loma Linda University

NCT05031663

COMPLETED 59 participants

Study on Immunopathogenesis in HIV and Hepatitis C Coinfection

Rush University Medical Center

NCT01296529

COMPLETED Phase 2 56 participants

Safety/Efficacy of Nepafenac Punctal Plug Delivery System Compared to Placebo to Control Ocular Pain/Inflammation After Cataract

Mati Therapeutics

NCT03496467

COMPLETED Phase 2 55 participants

Antiplatelet Therapy in HIV

NYU Langone Health

NCT02559414

COMPLETED NA 52 participants

Zinc Supplementation and Cardiovascular Risk in HIV

Grace McComsey

NCT02856269

COMPLETED NA 50 participants

The Impact of a Polyphenol-Rich Supplement on Epigenetic and Cellular Markers of Immune Age

Big Bold Health, PBC

NCT05234203

COMPLETED NA 48 participants

Bioequivalency Study of Meloxicam Tablets Under Fed Conditions

Roxane Laboratories

NCT00601887

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Phase Distribution

PhaseTrial count
Phase 1 10
Phase 2 16
Phase 3 8
Phase 4 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Inflammation Trial Landscape

133 indexed Inflammation studies · 51 recruiting (38%).

Phase mix: 13 late (III/IV) vs 26 early (I/II).

Top sponsor: Massachusetts General Hospital (6 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Inflammation?

PlainTrial tracks 133 US clinical trials for Inflammation, of which 51 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Inflammation?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.