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Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury
NCT04810858 · View on ClinicalTrials.gov ↗
Study Summary
This study applies a hypothesis-driven approach to examine the effects of chronic marijuana use on HIV-associated inflammation and its subsequent impacts on central nervous system function, with the goal of identifying the mechanisms through which cannabinoids modulate neurological disorders and other comorbidities in persons with HIV.
Conditions Studied
Interventions
- OTHER Multimodal, multi-parametric MRI
- OTHER Immune and cytokine profiling
- BEHAVIORAL Neuropsychological testing
Study Locations (1)
North Carolina
- Biotech Place — Winston-Salem
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 220 participants |
| Start Date | 2021-08-18 |
| Est. Completion | 2026-05-31 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04810858
The ClinicalTrials.gov registry entry for NCT04810858 describes a study currently listed as recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 220 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Wake Forest University Health Sciences, which has 1,061 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 5 conditions, with HIV appearing as the primary indexed condition, and to 3 interventions — of which Multimodal, multi-parametric MRI is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04810858 reports 1 study location spanning 1 distinct geographic area — top geographies include North Carolina. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04810858 about?
NCT04810858 is a clinical study titled "Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury". This study applies a hypothesis-driven approach to examine the effects of chronic marijuana use on HIV-associated inflammation and its subsequent impacts on central nervous system function, with the goal of identifying the mechanisms through which cannabinoids modulate neurological disorders and oth...
What is the current status of trial NCT04810858?
This trial is currently recruiting. It is a NA study. The enrollment target is 220 participants. The study started on 2021-08-18. Estimated completion is 2026-05-31.
What conditions does trial NCT04810858 study?
This clinical trial studies the following conditions: HIV, Inflammation, Cognition, Cannabis, Neuroimaging. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04810858?
The interventions under investigation include: Multimodal, multi-parametric MRI (OTHER), Immune and cytokine profiling (OTHER), Neuropsychological testing (BEHAVIORAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04810858?
This trial is sponsored by Wake Forest University Health Sciences, which has 1,061 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04810858 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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