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NCT04810858 · ClinicalTrials.gov registry record · NA
Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury
A NA study of HIV and Inflammation, sponsored by Wake Forest University Health Sciences.
- Recruiting
- Registry status
- NA
- Development phase
- 220
- Enrollment target
- 1
- Study location
NCT04810858: Recruiting NA study of HIV and Inflammation, sponsored by Wake Forest University Health Sciences.
NCT04810858 is a NA study of HIV and Inflammation that is actively recruiting participants, run by Wake Forest University Health Sciences. The registered enrollment target is 220 participants, below the 439-participant average among 303 other HIV trials with a reported enrollment target (50% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04810858, a NA study of HIV and Inflammation, is actively recruiting participants, sponsored by Wake Forest University Health Sciences.
- RECRUITING
- Registry status
- NA
- Development phase
- 220 participants
- Enrollment target
- 1
- Study location
Study Summary
This study applies a hypothesis-driven approach to examine the effects of chronic marijuana use on HIV-associated inflammation and its subsequent impacts on central nervous system function, with the goal of identifying the mechanisms through which cannabinoids modulate neurological disorders and other comorbidities in persons with HIV.
Primary Outcome
The neuropsychological testing battery assesses 7 cognitive domains with 3-4 tests per domain. Raw scores from each test will be converted to demographically adjusted standard scores, called T-scores using up-to-date US normative data. A T-score of 50 is considered the normative mean, and each 10-point deviation is equivalent to 1 standard deviation. The minimum possible T-score is 0 and the maximum is 100, with higher scores meaning better neurocognitive function. The average T-score for all te
Conditions Studied
Interventions
- OTHER Multimodal, multi-parametric MRI
- OTHER Immune and cytokine profiling
- BEHAVIORAL Neuropsychological testing
Study Locations (1)
North Carolina
- Biotech Place - Winston-Salem
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 220 participants |
| Start Date | 2021-08-18 |
| Est. Completion | 2026-05-31 |
| Phase | NA |
What NCT04810858 shows while recruiting
NCT04810858 is an interventional study that assigns participants to a tested intervention. The registered 220 participants enrollment target is mid-sized for trials with a published cap, below the 439-participant average among 303 other HIV trials with a reported enrollment target (50% lower).
The record links to 5 conditions, with HIV appearing as the primary indexed condition, and to 3 interventions - of which Multimodal, multi-parametric MRI is the first listed.
NCT04810858 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT04810858 about?
NCT04810858 is a clinical study titled "Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury". This study applies a hypothesis-driven approach to examine the effects of chronic marijuana use on HIV-associated inflammation and its subsequent impacts on central nervous system function, with the goal of identifying the mechanisms through which cannabinoids modulate neurological disorders and oth...
What is the current status of trial NCT04810858?
This trial is currently recruiting. It is a NA study. The enrollment target is 220 participants. The study started on 2021-08-18. Estimated completion is 2026-05-31.
What conditions does trial NCT04810858 study?
This clinical trial studies the following conditions: HIV, Inflammation, Cognition, Cannabis, Neuroimaging.
What interventions are being tested in trial NCT04810858?
The interventions under investigation include: Multimodal, multi-parametric MRI (OTHER), Immune and cytokine profiling (OTHER), Neuropsychological testing (BEHAVIORAL).
Who is sponsoring clinical trial NCT04810858?
This trial is sponsored by Wake Forest University Health Sciences, which has 1,140 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04810858 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for HIV
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04810858's enrollment target sits among peer trials
220 96th of 303 higher than 208 of 303 other HIV trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other HIV trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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