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NCT07222683 · ClinicalTrials.gov registry record
The Impact of Renal Transplant on Coronary Microvascular Function Among Patients With Advanced Chronic Kidney Disease
A clinical trial of Inflammation and Chronic Kidney Disease, sponsored by Brigham and Women's Hospital.
- Recruiting
- Registry status
- 80
- Enrollment target
- 1
- Study location
NCT07222683: Recruiting study of Inflammation and Chronic Kidney Disease, sponsored by Brigham and Women's Hospital.
NCT07222683 is a study of Inflammation and Chronic Kidney Disease that is actively recruiting participants, run by Brigham and Women's Hospital. The registered enrollment target is 80 participants, below the 288-participant average among 132 other Inflammation trials with a reported enrollment target (72% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07222683, a study of Inflammation and Chronic Kidney Disease, is actively recruiting participants, sponsored by Brigham and Women's Hospital.
- RECRUITING
- Registry status
- 80 participants
- Enrollment target
- 1
- Study location
Study Summary
People with chronic kidney disease (CKD) often experience faster aging of the heart and blood vessels, which raises the risk of heart problems beyond traditional factors like high blood pressure or cholesterol. One early sign is reduced blood flow in the tiny vessels that supply the heart, measured by a positron emission tomography (PET) scan using a marker called myocardial flow reserve (MFR). In CKD, ongoing inflammation and abnormal blood vessel growth can damage these small vessels, leading to heart stiffness and weaker heart function. A kidney transplant offers a unique chance to study how better kidney function and reduced inflammation affect heart health. The observational RESTORE study ("Impact of Renal Transplant on Coronary Microvascular Function in Patients with Advanced CKD") will measure heart blood flow and function before and after transplant. The study will test whether: 1. Inflammation and abnormal vessel growth are linked to poor heart blood flow and heart function in CKD. 2. Kidney transplant improves heart blood flow and function. 3. Lower inflammation after transplant leads to better heart health. By understanding how kidney disease and inflammation affect the heart-and how transplant may reverse these effects-this research could help guide future treatments to better protect heart health in patients with CKD.
Primary Outcome
Myocardial blood flow with hyperemic stress measured on PET myocardial perfusion imaging
Conditions Studied
Study Locations (1)
Massachusetts
- Brigham and Women's Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2023-03-10 |
| Est. Completion | 2030-07 |
What NCT07222683 shows while recruiting
NCT07222683 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 288-participant average among 132 other Inflammation trials with a reported enrollment target (72% lower).
The record links to 4 conditions, with Inflammation appearing as the primary indexed condition, and to 0 interventions.
NCT07222683 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT07222683 about?
NCT07222683 is a clinical study titled "The Impact of Renal Transplant on Coronary Microvascular Function Among Patients With Advanced Chronic Kidney Disease". People with chronic kidney disease (CKD) often experience faster aging of the heart and blood vessels, which raises the risk of heart problems beyond traditional factors like high blood pressure or cholesterol. One early sign is reduced blood flow in the tiny vessels that supply the heart, measured ...
What is the current status of trial NCT07222683?
This trial is currently recruiting. The enrollment target is 80 participants. The study started on 2023-03-10. Estimated completion is 2030-07.
What conditions does trial NCT07222683 study?
This clinical trial studies the following conditions: Inflammation, Chronic Kidney Disease, Kidney Transplant, Coronary Microvascular Dysfunction (CMD).
Who is sponsoring clinical trial NCT07222683?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07222683 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07222683's enrollment target sits among peer trials
80 52nd of 132 higher than 79 of 132 other Inflammation trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Inflammation trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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