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NCT07222683 · ClinicalTrials.gov registry record
The Impact of Renal Transplant on Coronary Microvascular Function Among Patients With Advanced Chronic Kidney Disease
A clinical trial of Inflammation and Chronic Kidney Disease, sponsored by Brigham and Women's Hospital.
- Recruiting
- Registry status
- 80
- Enrollment target
- 1
- Study location
NCT07222683 is a study of Inflammation and Chronic Kidney Disease that is actively recruiting participants, run by Brigham and Women's Hospital. The registered enrollment target is 80 participants, below the 288-participant average among 132 other Inflammation trials with a reported enrollment target (72% lower). The trial reports 1 study location across 1 state.
The verdict
NCT07222683, a study of Inflammation and Chronic Kidney Disease, is actively recruiting participants, sponsored by Brigham and Women's Hospital.
- RECRUITING
- Registry status
- 80 participants
- Enrollment target
- 1
- Study location
Study Summary
People with chronic kidney disease (CKD) often experience faster aging of the heart and blood vessels, which raises the risk of heart problems beyond traditional factors like high blood pressure or cholesterol. One early sign is reduced blood flow in the tiny vessels that supply the heart, measured by a positron emission tomography (PET) scan using a marker called myocardial flow reserve (MFR). In CKD, ongoing inflammation and abnormal blood vessel growth can damage these small vessels, leading to heart stiffness and weaker heart function. A kidney transplant offers a unique chance to study how better kidney function and reduced inflammation affect heart health. The observational RESTORE study ("Impact of Renal Transplant on Coronary Microvascular Function in Patients with Advanced CKD") will measure heart blood flow and function before and after transplant. The study will test whether: 1. Inflammation and abnormal vessel growth are linked to poor heart blood flow and heart function in CKD. 2. Kidney transplant improves heart blood flow and function. 3. Lower inflammation after transplant leads to better heart health. By understanding how kidney disease and inflammation affect the heart-and how transplant may reverse these effects-this research could help guide future treatments to better protect heart health in patients with CKD.
Conditions Studied
Study Locations (1)
Massachusetts
- Brigham and Women's Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2023-03-10 |
| Est. Completion | 2030-07 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07222683
The ClinicalTrials.gov registry entry for NCT07222683 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 80 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 288-participant average among 132 other Inflammation trials with a reported enrollment target (72% lower). The listed sponsor is Brigham and Women's Hospital, which has 937 total studies on file at ClinicalTrials.gov.
The record links to 4 conditions, with Inflammation appearing as the primary indexed condition, and to 0 interventions.
NCT07222683 reports 1 study location spanning 1 distinct geographic area - top geographies include Massachusetts.
Frequently Asked Questions
What is clinical trial NCT07222683 about?
NCT07222683 is a clinical study titled "The Impact of Renal Transplant on Coronary Microvascular Function Among Patients With Advanced Chronic Kidney Disease". People with chronic kidney disease (CKD) often experience faster aging of the heart and blood vessels, which raises the risk of heart problems beyond traditional factors like high blood pressure or cholesterol. One early sign is reduced blood flow in the tiny vessels that supply the heart, measured ...
What is the current status of trial NCT07222683?
This trial is currently recruiting. The enrollment target is 80 participants. The study started on 2023-03-10. Estimated completion is 2030-07.
What conditions does trial NCT07222683 study?
This clinical trial studies the following conditions: Inflammation, Chronic Kidney Disease, Kidney Transplant, Coronary Microvascular Dysfunction (CMD).
Who is sponsoring clinical trial NCT07222683?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07222683 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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